Navigation Links
'Fishy' clue helps establish how proteins evolve
Date:1/27/2009

New Haven, Conn. Three billion years ago, a "new" amino acid was added to the alphabet of 20 that commonly make up proteins in organisms today. Now researchers at Yale and the University of Tokyo have demonstrated how this rare amino acid and, by example, other amino acids made its way into the menu for protein synthesis. The study appeared in the December 31 advance online publication of the journal Nature.

The rare amino acid the Yale researchers studied, pyrrolysine (Pyl), gave the researchers a molecular handle by being an extreme example of an amino acid that evolved to serve a highly specific need.

The amino acid alphabet shapes the language of proteins. When the genetic code was deciphered four decades ago, scientists believed that there were no more than 20 amino acid "letters" that universally meshed with the nucleic acid part of the protein code. But, like many alphabets, the language of proteins has letters with modifications like accent marks that modify their use.

When cells make proteins, a tightly coordinated pair of molecules a tRNA and a tRNA synthetase ensure that the correct amino acid is added in a growing protein chain. These molecules are highly specific for the amino acid they "manage" and are coded directly in the genome. All of the 20 common amino acids are incorporated into proteins in this way. However, only two uncommon amino acids, including Pyl, have been discovered that follow this pattern.

In most cases, an uncommon amino acid in proteins like letters with accent marks results from modification of one of the standard 20 amino acids after it has become part of the protein. Many human proteins are modified in this way, and deficiencies in these modifications are linked to myriad human diseases including cancer, neurodegeneration, and metabolic disorders.

"Pyl turns out to be special because it represents an uncommon amino acid that is incorporated during normal protei
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Fishy future written in the genes
2. Natural chemical found in broccoli helps combat skin blistering disease
3. Device helps patients survive, regain function til transplant
4. Presence of gene mutation helps guide thyroid cancer treatment
5. CABI helps phase out dangerous pesticide in EU
6. Diet support helps chronic kidney patients
7. Argonne helps China create cleaner Beijing for 2008 Olympics
8. A tiny pinch from a z-ring helps bacteria cells divide
9. Ultraviolet light helps to secure water supply
10. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
11. Handbook helps parents deal with childhood infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fishy' clue helps establish how proteins evolve
(Date:1/22/2015)... , Jan. 13, 2015 Technology Showcase, Hall E - ... authentication solutions, today announced it will showcase its EyeLock ID ... by the Department of Energy,s Oak Ridge National Laboratory ... Show . EyeLock,s iris identity authentication technology is being used ...
(Date:1/22/2015)... Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication company ... of the Wocket™ smart wallet at CES 2015 in Las ... one of the "11 Hot Products at CES" in a review published ... Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... , January 22, 2015 , ... year  The European Patent Office to present a video ... British nominations to be featured: Christofer Toumazou and ... former finalists and winners of the Award   Starting ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... 27 January, 2010 - A recent special edition of the ... the impact of Hurricane Katrina and an overview of the ... Hurricane Katrina was the most destructive natural disaster in U.S. ... storm surge affected the greatest area, nearly 93,000 square miles. ...
... warming may impair the ability of ecosystems to ... and carbon sequestrationsays the nation,s largest organization of ... Ecological Society of America (ESA) outlines strategies that ... to mitigate and adapt to climate change. ...
... This release is available in Spanish . ... minority groups receive worse health care in the treatment of ... developed countries. This conclusion emerges from a research conducted at ... bibliographic review worldwide to date on health care of this ...
Cached Biology News:A forensic analysis of Hurricane Katrina's impact: methods and findings 2Managing ecosystems in a changing climate 2Managing ecosystems in a changing climate 3Poorer diabetics receive worse care than other in countries with universal health coverage 2Poorer diabetics receive worse care than other in countries with universal health coverage 3
(Date:3/2/2015)... (PRWEB) March 02, 2015 The ... ReachMD announced today the launch of Genetically ... educate healthcare professionals on the application of human genetics ... series features peer-to-peer interviews conducted during the ASHG 2014 ... ,     Translational Genomics and Health Outcomes Research: What's Ready ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 In the ... industry has experienced robust growth. The industry, which ... industrial materials, energy resources and other goods, has grown ... government regulation. As a result, IBISWorld forecasts that industry ... to reach $946.8 million over the five-year period, including ...
(Date:3/2/2015)... , March 2, 2015 Analyzing ... experts have identified a new syndrome, shedding light ... research also provides important information to help caregivers ... eventually treating it. "This syndrome illuminates ... sort of master switch that controls many other ...
(Date:3/2/2015)... and VANCOUVER, British Columbia ... ("InMed") (CSE: IN; OTCQB: IMLFF), a clinical stage ... based therapies, today announced that Craig Schneider ... overview during a live webcast at VirtualInvestorConferences.com. ... LINK:   http://VirtualInvestorConferences.com > click the red ...
Breaking Biology Technology:American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 2American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 3Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 2Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 3New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 2New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 3New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 4InMed Pharmaceuticals to Present Investor Webcast March 5 2
... Pharsight,Corporation (Nasdaq: PHST ), a leading provider of ... announced today that it will be presenting at B. ... April 2, 2008 at the Palms Las,Vegas. Shawn O,Connor, ... and CFO, will be presenting on April 2nd,at 1:30 ...
... 26, Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ),the global specialty biopharmaceutical company, announces the ... plc,("Shares") in connection with the Shire Long Term Incentive Plan ("LTIP")., In accordance ... ... of Shares ...
... the leading provider of,ion channel testing services for ... conference the company,s expanding,line of ion channel services ... need to identify the most promising compounds,and eliminate ... invest millions in,the drug-development process. The 14th Annual ...
Cached Biology Technology:Pharsight to Present at B. Riley & Co. 9th Annual Las Vegas Investor Conference 2Shire plc: Long Term Incentive Plan 2ChanTest to Highlight Most-Comprehensive Range of Ion Channel Profiling Screens and Consultation Services at 14th Annual SBS Conference, Booth 1104 2ChanTest to Highlight Most-Comprehensive Range of Ion Channel Profiling Screens and Consultation Services at 14th Annual SBS Conference, Booth 1104 3
Rabbit polyclonal to IL23 P19 ( Abpromise for all tested applications). Antigen: Synthetic 16 amino acid peptide from near the amino terminus of human IL23 P19 Entrez Gene ID: 51561 Swiss...
...
Mouse monoclonal [CRC64] to Integrin alpha 2b + beta 3 ( Abpromise for all tested applications). Antigen: Human platelets Entrez Gene ID: 23295 Swiss Protein ID: P05106...
This antibody detects cdc42 on SDS-PAGE immunoblots....
Biology Products: