Navigation Links
Fish show autism-like gene expression in water with psychoactive pharmaceuticals
Date:6/8/2012

Psychoactive medications in water affect the gene expression profiles of fathead minnows in a way that mimics the gene expression patterns associated with autism spectrum disorder in genetically susceptible humans, according to research published June 6 in the open access journal PLoS ONE. These results suggest a potential environmental trigger for autism spectrum disorder in this vulnerable population, the authors write.

The researchers, led by Michael A. Thomas of Idaho State University, exposed the fish to three psychoactive pharmaceuticals fluoxetine, a selective serotonin reuptake inhibitor, or SSR1; venlafaxine, a serotonin-norepinephrine reuptake inhibitor, and carbamazepine, used to control seizures at concentrations comparable to the highest estimated environmental levels.

They found that the only gene expression patterns affected were those associated with idiopathic autism spectrum disorders, caused by genetic susceptibility interacting with unknown environmental triggers. These results suggest that exposure to environmental psychoactive pharmaceuticals may play a role in the development of autism spectrum disorder in genetically predisposed individuals.

Lead researcher Michael A. Thomas remarks, "While others have envisioned a causal role for psychotropic drugs in idiopathic autism, we were astonished to find evidence that this might occur at very low dosages, such as those found in aquatic systems."


'/>"/>

Contact: Lindsay Morton
lmorton@plos.org
415-935-2094
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
2. A new application allows online statistical analysis of gene-expression data
3. IU biologists offer clearer picture of how protein machine systems tweak gene expression
4. Microbial communities shifted dramatically after Deepwater Horizon spill
5. Scientists find that rain may not always be a welcome thing to waterbirds
6. Scientists discover huge phytoplankton bloom in ice-covered waters
7. The first pilot wastewater treatment plant with integrated wood production opened in Mongolia
8. Earths water cycle intensifying with atmospheric warming
9. Could cap and trade for water solve problems facing the United States largest rivers?
10. USF study: Common fungicide wreaks havoc on freshwater ecosystems
11. Begin early: Researchers say water with meals may encourage wiser choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... CENTRE, N.Y. , March 27, 2017 /PRNewswire-USNewswire/ ... Healthcare Information and Management Systems Society (HIMSS) Analytics ... Outpatient EMR Adoption Model sm . In addition, ... 12% of U.S. hospitals using an electronic medical ... CHS for its high level of EMR usage ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/23/2017)... DUBLIN , Mar. 23, 2017 Research ... Anti-Theft System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 8.8% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... 2017 , ... The Academy of Model Aeronautics (AMA), the ... (UAA), the unifying voice for collegiate aviation education, are launching a joint UAS ... success through a STEM-based education platform. , Much like the program currently available ...
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation ... infertility as a disease, bringing new hope for prospective parents who are challenged ... meeting to back the World Health Organization’s designation in hopes of changing the ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... Charm Sciences, ... validation. The AMPH test was determined to be appropriate as a screening test at ... interpretation, on the Charm EZ system, and the Charm EZ Lite system. These systems ...
(Date:6/20/2017)... ... 2017 , ... National executive search firm, Slone Partners, announces ... and biomarker expertise, as VP of Scientific Affairs at Cambridge Biomedical. , ... development and sample testing services. The organization acts as a leading provider of ...
Breaking Biology Technology: