Navigation Links
Fish oil linked to increased risk of colon cancer in mice
Date:10/5/2010

EAST LANSING, Mich. Fish oil long encouraged by doctors as a supplement to support heart and joint health, among other benefits induced severe colitis and colon cancer in mice in research led by Michigan State University and published this month in the journal Cancer Research.

Jenifer Fenton, a food science and human nutrition researcher at MSU, led the research that supports establishing a dose limit for docosahexaenoic acid (DHA), one of the omega-3 fatty acids present in fish oil, particularly in people suffering from chronic conditions such as inflammatory bowel diseases.

"We found that mice developed deadly, late-stage colon cancer when given high doses of fish oil," she said. "More importantly, with the increased inflammation, it only took four weeks for the tumors to develop."

Specifically, the research team found an increase in the severity of the cancer and an aggressive progression of the cancer in not only the mice receiving the highest doses of DHA but those receiving lower doses as well. The mice used in the study were prone to inflammatory-like bowel disease; inflammation is an important risk factor for many types of cancers, including colon cancer.

"Our findings support a growing body of literature implicating harmful effects of high doses of fish oil consumption in relation to certain diseases," Fenton said. "Currently, there is a call by academics and the food industry to establish dietary guidelines for omega-3 consumption. This is primarily motivated by the fact that most Americans are deficient in omega-3 fatty acids, and there is substantial evidence supporting the beneficial effects of the consumption."

The findings were surprising, specifically because DHA has been shown to have some anti-inflammatory properties, according to Fenton: "We hypothesized that feeding fish oil enriched with DHA to mice would decrease the cancer risk; we actually found the opposite. These mice were less eq
'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene variations that alter key enzyme linked to prostate cancer
2. Father absence linked to earlier puberty among certain girls
3. High testosterone levels linked to self-destructive CEO behavior, says Management Science
4. Low grades in adolescence linked to dopamine genes
5. High-fat diet during puberty linked to breast cancer risk later in life
6. Girls early puberty linked to unstable environment via insecure attachment in infancy
7. Fertilizer chemicals linked to animal developmental woes
8. USDA-backed study finds federal school lunches linked to childhood obesity
9. UCLA study identifies genetic variation linked to lupus in Asian men
10. Prenatal exposure to pesticides linked to attention problems
11. Gallbladder cancer may be linked to estrogens, says UH team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ... 2015-2019"  report to their offering. ... advances in technology. With continuous advances in technology, ... the latest standard that meets the needs and ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... of Nottingham have opened the way for more accurate ... by proving a long-held theory about how bacteria communicate ... of Molecular Medical Sciences have shown for the first ... a process called ,quorum sensing, directly depends on the ...
... A change in the formulation of tenofovir gel, an ... to use in the rectum, suggests a study published online ... In laboratory tests of rectal tissue, researchers from the ... less harmful to the lining of the rectum than the ...
... The movement patterns of critically endangered leatherback turtles ... the North Atlantic or the Eastern Pacific, with implications ... published May 16 in the open access journal ... Bailey of the University of Maryland Center for Environmental ...
Cached Biology News:Fighting bacteria's strength in numbers 2Reduced glycerin formulation of tenofovir vaginal gel safe for rectal use 2Reduced glycerin formulation of tenofovir vaginal gel safe for rectal use 3
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 Audacity, ... activation agency and member of the Huntsworth Health Group, ... to its executive team. In her role, Gonzales will ... , “We are incredibly honored to welcome a talent ... Chief and CEO, Gaëtan Fraikin. “She is a proven ...
(Date:12/17/2014)... , Dec. 17, 2014  United Therapeutics Corporation (NASDAQ: ... promotions as well as changes to Martine Rothblatt ... Promotions United Therapeutics announced the promotion ... Co-Chief Executive Officer and David Zaccardelli , Pharm.D. ... connection with these promotions, Dr. Rothblatt,s title will change ...
(Date:12/17/2014)... Calif. , Dec. 17, 2014 ... a Phase 2 study evaluating the investigational oral ... of patients with severe, chronic itch who are ... of care, including topical steroids and antihistamines. ... change in Visual Analog Scale (VAS) itch score ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to ... ParticleView V19 with PVM technology , is now ... and measurement tool continuously captures high-resolution images under ... then automatically prepares a report pairing the most ... concentration changes. This compelling blend of high resolution ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... & Conference Held in Pittsburgh - Over 1,000 Expected ... Attendees to Discuss New Technologies, New Business, PITTSBURGH, ... forum for the growing business of using,waste materials and ... will take place in downtown Pittsburgh,s David L. Lawrence,Convention ...
... Speaker at AdvaMed 2008 - Book signing to ... Healthcare policy,regulatory environment, elements of the global marketplace, ... 2008 MedTech Conference., Wednesday panel presentations will ... the wireless & IT sectors, remote patient monitoring,technologies, ...
... Researchers at The University of Texas at San Antonio (UTSA) ... of Texas Health Science Center at San Antonio (UTHSCSA) have ... controlling the early infectious process against Francisella tularensis, ... of tularemia. The findings will be released this week in ...
Cached Biology Technology:Former Speaker of the House Newt Gingrich Featured Wednesday 2UTSA/UTHSCSA publish results on bio-threat agent 2
... Protein Purification Protocols covers a wide ... for novice and experienced researchers in all ... This excerpt from the books preface illustrates ... to your research library., The chapters introduce ...
... Cellular uptake of long double stranded RNA ... interference in a diverse group of organisms ... RNA interference leads to the inhibition of ... of the target messenger RNA (mRNA). Attempts ...
... TrackerCumulates a score of movement counts, similar ... it.can track up to 6 subjects at once, ... triggered. Test a whole experimental group at ... the activity. Upgradeable for a variety of ...
... examining a novel object in the environment.The Spatial ... built around a video camera, frame grabber, and ... fields at once and up to 6 moving ... records them, but also allows video replay of ...
Biology Products: