Navigation Links
Fish oil -- helpful or harmful?
Date:1/14/2008

Toronto, ON Fish oil supplements may help some cardiac patients while harming others, suggests a new review of evidence compiled by St. Michaels Hospital and University of Toronto researchers.

In a systematic review of trials where patients with implantable cardioverter defibrillators used fish oil supplements, Dr. David Jenkins and Dr. Paul Dorian found significant differences among the trials, indicating fish oil may be beneficial to some patients while having a negative impact on others.

Fish oils can have complex and varied effects on the heart, says Jenkins, a U of T Professor of Medicine who runs the Clinical Nutrition and Risk Factor Modification Centre at St. Michaels Hospital. These effects include blocking cardiac ion channels, reducing fibrosis in response to mechanical stress, decreasing blood coagulation, and possibly altering immune function.

There is evidence from multiple large-scale population (epidemiologic) studies and randomized controlled trials that intake of recommended amounts of DHA and EPA in the form of dietary fish or fish oil supplements can reduce the risk of death, heart attack and dangerous abnormal heart rhythms in people with known cardiovascular disease, as well as potentially slow hardening of the arteries and lower blood pressure slightly. But the evidence also shows high doses can have harmful effects, such as an increased risk of bleeding. Although benefits are proposed for alpha-linolenic acid, scientific evidence is less compelling and beneficial effects may be less pronounced.

The meta-analysis reveals that studies in different patient populations with different pathophysiologies and therapeutic regimens have all produced divergent results. However, more recent data suggests that particular caution should be exercised when analyzing data from certain subgroups, such as men with stable angina. The same may also be true for patients with implantable cardioverter defibrillators who have a history of ventricular tachycardia and who are not taking antiarrhythmic medications.

Fish oils have promise as beneficial in cardiovascular disease but our work highlights our gaps in understanding and the need for more research, adds Dorian, a cardiologist at St. Michaels Hospital and U of T Professor of Medicine University of Toronto.

The review, which will appear in the January 15 edition of the Canadian Medical Association Journal, also indicates that further research and large randomized controlled trials are needed before long-chain omega-3 fatty acids are used in patients with heart failure and angina.


'/>"/>

Contact: April Kemick
april.kemick@utoronto.ca
416-978-5949
University of Toronto
Source:Eurekalert

Related biology news :

1. Breastfeeding boost IQ in infants with helpful genetic variant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... TEL AVIV, Israel , May 24, 2016   ... on providing physicians with artificial intelligence, real-time decision support tools ... selected to present at the 2016 Israeli Advanced Technology Industries ... part of Israel,s 15th National Life ... to 26th at the David Intercontinental Hotel in ...
(Date:5/24/2016)... Rockville, Maryland (PRWEB) , ... May 24, 2016 ... ... introduction of a newly re-branded identity. The new Media Cybernetics corporate branding reflects ... the world of imaging and image analysis. The re-branding components include a crisp, ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... Precision Farming in 2017 and Beyond. The paper outlines the key trends that ... ag industry. , “We’ve witnessed a lot of highs and lows as the ...
(Date:5/23/2016)... 23, 2016 Oxitec CEO Hadyn ... at 10:15 a.m. ET before the United States House Committee ... mosquitos can play in controlling the spread of the ... virus.      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) ... a self-limiting gene. Trials in Brazil , ...
Breaking Biology Technology: