Navigation Links
Fish oil -- helpful or harmful?
Date:1/14/2008

Toronto, ON Fish oil supplements may help some cardiac patients while harming others, suggests a new review of evidence compiled by St. Michaels Hospital and University of Toronto researchers.

In a systematic review of trials where patients with implantable cardioverter defibrillators used fish oil supplements, Dr. David Jenkins and Dr. Paul Dorian found significant differences among the trials, indicating fish oil may be beneficial to some patients while having a negative impact on others.

Fish oils can have complex and varied effects on the heart, says Jenkins, a U of T Professor of Medicine who runs the Clinical Nutrition and Risk Factor Modification Centre at St. Michaels Hospital. These effects include blocking cardiac ion channels, reducing fibrosis in response to mechanical stress, decreasing blood coagulation, and possibly altering immune function.

There is evidence from multiple large-scale population (epidemiologic) studies and randomized controlled trials that intake of recommended amounts of DHA and EPA in the form of dietary fish or fish oil supplements can reduce the risk of death, heart attack and dangerous abnormal heart rhythms in people with known cardiovascular disease, as well as potentially slow hardening of the arteries and lower blood pressure slightly. But the evidence also shows high doses can have harmful effects, such as an increased risk of bleeding. Although benefits are proposed for alpha-linolenic acid, scientific evidence is less compelling and beneficial effects may be less pronounced.

The meta-analysis reveals that studies in different patient populations with different pathophysiologies and therapeutic regimens have all produced divergent results. However, more recent data suggests that particular caution should be exercised when analyzing data from certain subgroups, such as men with stable angina. The same may also be true for patients with implantable cardioverter defibrillators who have a history of ventricular tachycardia and who are not taking antiarrhythmic medications.

Fish oils have promise as beneficial in cardiovascular disease but our work highlights our gaps in understanding and the need for more research, adds Dorian, a cardiologist at St. Michaels Hospital and U of T Professor of Medicine University of Toronto.

The review, which will appear in the January 15 edition of the Canadian Medical Association Journal, also indicates that further research and large randomized controlled trials are needed before long-chain omega-3 fatty acids are used in patients with heart failure and angina.


'/>"/>

Contact: April Kemick
april.kemick@utoronto.ca
416-978-5949
University of Toronto
Source:Eurekalert

Related biology news :

1. Breastfeeding boost IQ in infants with helpful genetic variant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
(Date:5/23/2017)... Italy , May 23, 2017  Hunova, the first robotic gym ... trunk, has been officially launched in Genoa, Italy . ... Europe and the USA . The technology ... on the market by the IIT spin-off Movendo Technology thanks to a ... the Multimedia News Release, please click: ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply for ... time. So which eye do you rinse first if a dangerous substance enters both eyes? ... Eye Wash with its unique dual eye piece. , “Whether its dirt and debris, ...
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
(Date:10/10/2017)... -- International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... market and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase ... "The residential security market has experienced continued growth, ...
Breaking Biology Technology: