Navigation Links
Fish flu: Genetics approach may lead to treatment
Date:11/9/2011

A research team at the National Institute of Standards and Technology (NIST) has provided the first look* at a genetic structure that may play a critical role in the reproduction of the infectious salmon anemia virus (ISAV), more commonly known as the "fish flu." A scourge in fish farms with a mortality rate as high as 90 percent, ISAV was recently found in wild salmon in the Pacific Northwest for the first time, threatening an already dwindling population and the vast food web it supports.

While there is a vaccine for the virus, it must be administered by injectiona task that is both cumbersome and economically impractical for the aquaculture industry. A drug or vaccine that prevents the spread of the disease by interfering with the virus' ability to replicate its genetic code (contained in eight segments of ribonucleic acid or RNA) would be far more practical for fish farmers and marine biologists to deliver.

Robert Brinson, a NIST scientist working at the Hollings Marine Laboratory (HML) in Charleston, S.C., and NIST colleagues Andrea Szakal and John Marino working at the Institute for Bioscience and Biotechnology Research (IBBR) in Rockville, Md., knew from the scientific literature that the family of viruses that includes both the many types of influenzathe causes of yearly human flu outbreaksand infectious salmon anemia, form "panhandle" structures in their genomic RNA. In human influenza, these panhandles are known to interact with proteins that begin the process of copying and replicating the virus.

Hypothesizing that the fish flu virus might function the same way, Brinson and his colleagues used high-resolution nuclear magnetic resonance (NMR) spectroscopy and thermal melting methods to look at the genetic structure in the same region of the ISAV RNA. They found that the ISAV genome does appear to have a panhandle "motif" (the poetic term used by geneticists to define a discrete nucleotide sequence that functions independently of the rest of the genome and directs a specific biological function). The NIST work provides the first experimental evidence and characterization of this panhandle motif that may function similarly in the fish virus as the "green light" for viral RNA replication processes.

"The next step," Brinson says, "is to investigate the relevant proteins and how they interface with the RNA. What molecular features drive the protein to recognize the RNA? How is it binding, and how is it interacting with the RNA?" Brinson says that this work may facilitate the development of new approaches for interfering with the replication of these viruses to mitigate the effects of ISAV on the aquaculture of salmon. It also demonstrates that the salmon virus can be used as an experimental model for understanding the replication machinery of human and other related influenza viruses.

The HML is a unique partnership of governmental and academic agencies including NIST, NOAA's National Ocean Service, the South Carolina Department of Natural Resources, the College of Charleston and the Medical University of South Carolina. The HML NMR facility focuses on the multi-institutional mission of metabolomics, natural products and structural biology. The IBBR is a University System of Maryland joint research enterprise created to enhance collaboration among the University of Maryland College Park, The University of Maryland Baltimore and NIST.


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Modern genetics vs. ancient frog-killing fungus
4. New research helps explain genetics of Parkinsons disease
5. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
6. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
7. Study examining role of genetics and environment in type 1 diabetes
8. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
9. Roberta A. Pagon receives lifetime award in genetics from March of Dimes
10. Margarita Saenz, M.D. is recipient of Genzyme/ACMGF Fellowship in Biochemical Genetics
11. Bad mix of bacterial remnants and genetics leads to arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fish flu: Genetics approach may lead to treatment
(Date:3/9/2017)... , March 9, 2017 4Dx has publicly ... Lung Imaging Workshop at the University of Pennsylvania. Founder ... to deliver the latest data to world leaders in ... brings together leaders at the forefront of the industry ... imaging. "The quality of the imaging ...
(Date:3/6/2017)... SAN MATEO, Calif. , March 6, 2017 ... predictive marketing and sales technology, today announced Predictive ... (AI) solution for infusing actionable sales intelligence into ... customers to automatically enable their sales organizations with ... contextual messages that allow for intelligent engagement. Predictive ...
(Date:3/2/2017)... , March 2, 2017 Australian stem ... (ASX: CYP), has signed an agreement with the ... the Monash Biomedicine Discovery Institute and Department of Pharmacology ... conduct a further preclinical study to support the use ... of asthma.  Asthma is a chronic, ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... 24, 2017 Sinovac Biotech Ltd. ("Sinovac" or the "Company") ... China , today announced that its board of directors has ... the plan from March 27, 2017 to March 27, 2018. The amendment ... About Sinovac Biotech Ltd. ... Sinovac Biotech Ltd. is a China ...
(Date:3/23/2017)... ... 23, 2017 , ... Lajollacooks4u is proud to announce it has become the premiere team-building cooking ... for companies around the world, such as Illumina, HP and Qualcomm, and is ranked #1 ... increasing popularity is due to its new team building format, a way for teams to ...
(Date:3/23/2017)... -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical ... reported financial results for the quarter and year ... update on the company,s clinical development efforts and ... pleased to report that last year was a ... Krammer. "We achieved key clinical milestones and attracted ...
(Date:3/23/2017)...  Agriculture technology company Cool Planet has closed on ... to commercialize its Cool Terra and Cool Fauna Engineered ... that are simultaneously profitable as well as sustainable and ... months. This latest round of funding was led by ... The company,s primary product, Cool Terra, can improve ...
Breaking Biology Technology: