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First trial of pemetrexed with radiation and chemo in lung cancer shows promising results
Date:4/30/2010

hen given concurrently with cisplatin and radiotherapy," Prof Mornex said. "It appears to be the only third generation agent that can likely be recommended safely at full dose in trials with concurrent radiotherapy."

"This is important because, most of the time, when combining radiation and chemotherapy concurrently, the dose of chemotherapy must be decreased due to excessive toxicity. The problem is that by reducing the chemotherapy dose, one reduces the efficacy of the chemotherapy on micro metastases and on the primary tumor. But with pemetrexed, the tolerance is good and allows us to maintain high cytotoxic doses during radiation, increasing the chance of killing cancerous cells."

"We are very happy to present these data, which will have an impact on clinical practice in the near future," Prof Mornex added. "This regimen is already being studied in several ongoing clinical trials around the world; it may become the treatment of choice in the future, for concurrent chemo-radiation schemes."


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Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

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