Navigation Links
First trial in patients with a potential treatment of the incurable ALS muscle disease
Date:12/1/2008

Leuven (Belgium), Stockholm (Sweden) Permission has been granted to start the first safety and tolerability trial on patients for a remedy for ALS. ALS is an incurable, paralyzing neurodegenerative disorder that strikes 5 persons in every 100,000. The disease commonly affects healthy people in the most active period of their lives − without warning. Researchers from VIB at the K.U.Leuven have previously shown the possibilities for the use of VEGF in the treatment of ALS through work in animal models. The Swedish Biopharmaceutical company NeuroNova has already built upon this research. Together with UZ Leuven they'll start the first evaluation of safety and tolerability of the drug in patients by the end of this year. This is an important step in the development of a new treatment. It will take several years before the protein can be made available as a medicine.

An incurable disease of the muscles

Amyotrophic Lateral Sclerosis (ALS) can strike anyone. The Chinese leader Mao Tse Tung, Russian composer Dimitri Shostakovich, the legendary New York Yankee baseball player Lou Gehrig, and astro-physicist Stephen Hawking have all been afflicted with ALS. About half of the patients dies within three years − some even in the first year − usually as a consequence of suffocation.

In ALS, the patient's nerve bundles that extend to the muscles deteriorate. As a result the patient loses control of the muscles, and progressively becomes paralyzed. The originating mechanism of this deadly disease of deterioration − which has an enormous medical and social impact − remains obscure. At present, the disease is totally untreatable.

VEGF: a promising candidate drug

VEGF is a substance that controls the growth of blood vessels. Unexpectedly, VEGF also helps neurons survive under stressful conditions. In 2001 Peter Carmeliet's team showed that too little VEGF causes ALS-like symptoms in mice. Late
'/>"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dictyostelium cells shown to lay breadcrumb trail as first step in multicellular formation
2. Caltech researchers get first 3-D glimpse of bacterial cell-wall architecture
3. Planetary first family discovered by astronomers using Gemini and Keck Observatories
4. Planetary "first family" discovered by astronomers using Gemini and Keck Observatories
5. First at-home test for vasectomized men proves to be safe, accurate
6. Washington University scientists first to sequence genome of cancer patient
7. First results from hospital trials testing
8. Scientists achieve first tracking of salmon from headwaters in Rockies through Pacific to Alaska
9. First comprehensive genomic study of common cold reveals new treatment targets
10. Synaptics Reports Record Results for First Quarter of Fiscal 2009
11. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
(Date:3/24/2015)... Mar. 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ... Biometrics - Global Strategic Business Report" report to their offering. ... Voice Biometrics in US$ Thousands by the following Segments: Face Biometrics, ... US, Canada , Japan , ... Middle East & Africa , ...
(Date:3/23/2015)... ANGELES , March 23, 2015  In the ... Federal fraud case conviction losses. This figure accounts for ... which, according to The Nilson Report, exceeds $11 billion ... investigative tool after a crime has occurred. Investor ... and polygraph expert Joe Paolella partnered to ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Jolla- Salk Institute scientist Ronald Evans has been selected ... in Medicine, Israel,s highest award for achievements benefiting mankind. ... for his discovery of the gene super-family encoding nuclear ... class of receptors. Evans, professor and head of ...
... (Jan. 18, 2012) The National Eye Institute has ... subsidiary of Mass. Eye and Ear, a five year-grant ... of eye allergies (NEI Grant Number 1R01EY021798-01A1). Daniel ... the project formally entitled "Cellular and Molecular Mechanisms that ...
... Ind. -- An international team of microbiologists led by Indiana ... one that occurs at a single end or pole of ... axis of the cell -- that could have implications in ... past detailed studies of rod-shaped bacteria such as Escherichia ...
Cached Biology News:Salk scientist Ronald M. Evans wins 2012 Wolf Prize in Medicine 2Polar growth at the bacterial scale reveals potential new targets for antibiotic therapy 2Polar growth at the bacterial scale reveals potential new targets for antibiotic therapy 3
(Date:5/5/2015)... SAN DIEGO AND TORONTO, May 5, 2015 /PRNewswire/ - Aptose ... "Company") today reported financial results for the three months ... Unless specified otherwise, all amounts are in Canadian dollars. ... changed its fiscal year end from May 31 to ... current interim period being reported is for the three ...
(Date:5/5/2015)... 05, 2015 Research and Markets ... addition of the "Separation Systems Market ... Macromolecules which include protein, RNA, ... are broken into smaller molecules, during production ... requires various advanced systems like centrifugation, liquid ...
(Date:5/5/2015)... , May 5, 2015 Reprints Desk, Inc., ... providing on-demand access to scientific, technical and medical (STM) ... the Association of Southeastern Research Libraries (ASERL) . ... libraries located across 11 southeastern states. Founded in 1956, ... collaborative programs to address the continually changing needs of ...
(Date:5/5/2015)... , May 05, 2015 Research and ... the addition of the "Clinical Laboratory, Molecular ... Forecast 2015 to 2019 - Global Version" ... developments especially in the area of molecular diagnostics ... growing and evolving world market that is moving ...
Breaking Biology Technology:Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 3Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 4Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 5Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 6Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 7Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 8Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2
... 6, 2011 AlloSource, ( www.allosource.org ) ... soft-tissue allografts for use in surgical procedures around the ... by the Denver Business Journal,s inaugural awards ... costs and diminishing employee benefits, the Denver Business ...
... (OTC.BB: NWBO) (NORTHWEST BIO) today announced that it has ... by the end of the quarter, with 17 sites ... and active where patients can enroll in the Company,s ... multiforme (GBM), the most lethal form of brain cancer. ...
... ProteinSimple today announced the launch of the ... of protein-based therapeutics. The iCE3 platform will be ... 9-13, 2011, at Amelia Island, FL. ... closely. Imaged capillary electrophoresis (iCE) systems detect subtle ...
Cached Biology Technology:AlloSource Named One of Denver's Healthiest Employers 2AlloSource Named One of Denver's Healthiest Employers 3NORTHWEST BIO Announces Positive Third Quarter Progress 2NORTHWEST BIO Announces Positive Third Quarter Progress 3NORTHWEST BIO Announces Positive Third Quarter Progress 4ProteinSimple Launches New System for Protein Biologics 2
... disposable microfiltration devices for the fast and reliable ... l to 500 l. They can be used ... tubes. Product Features: High-flux Polyethersulphonemembrane ... hold up volume ( Fast and reproducible performance ...
... Workstation fully automates pharmaceutical sample preparation ... sample transfer, mixing and dilutions. Capabilities ... detection. The Prelude performs these functions ... Part 11. The Prelude performs ...
... Use in any standard fixed-angle ... 16,000 g.,Spin- centrifuge tube filters ... within a centrifuge tube. They filter ... removal, HPLC sample preparation, removal of ...
... (or medium binding) polystyrene surface is ... through passive interactions,• Is suitable primarily ... such as antibodies, that have large ... the surface,• Binding capacity of approximately ...
Biology Products: