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First study hints at insights to come from genes unique to humans
Date:3/21/2008

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He also found evidence that the protein was helping to activate RAS, another gene whose protein is commonly found in human cancers.

Stahl and his colleagues plan additional research to learn whether the other paralogs of TBC1D3 have different roles. He also has several ideas for learning more about the functions of human-only genes.

"We might try an organ-by-organ approach, looking to see if any genes specific to a particular organs, such as fat, are specific to humans," he says. "We also should probably look at crystallizing the proteins from some of these genes, which can tell us more about what they interact with."

There may be human diseases where these genes are mutated or missing, Stahl speculates. The effects of such conditions could provide important clues to what the humans-only genes do.

"It's also going to be very interesting for evolutionary biologists to try to develop a sense for where these humans-only genes come from," Stahl says. "The building blocks of these genes may be present but not active in earlier species."


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Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

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