Navigation Links
First step toward electronic DNA sequencing: Translocation through graphene nanopores
Date:7/26/2010

silicon nitride. An even smaller hole, the nanopore in the very center of the suspended graphene, was then drilled with an electron beam of a transmission electron microscope, or TEM.

Solid-state nanopores are proving to be invaluable tools for probing biology at the single-molecule level.

Graphene nanopore devices developed by the Penn team work in a simple manner. The pore divides two chambers of electrolyte solution and researchers apply voltage, which drives ions through the pores. Ion transport is measured as a current flowing from the voltage source. DNA molecules, inserted into the electrolyte, can be driven single file through such nanopores.

As the molecules translocate, they block the flow of ions and are detected as a drop in the measured current. Because the four DNA bases block the current differently, graphene nanopores with sub-nanometer thickness may provide a way to distinguish among bases, realizing a low-cost, high-throughput DNA sequencing technique.

In addition, to increase the robustness of graphene nanopore devices, Penn researchers also deposited an ultrathin layer, only a few atomic layers thick, of titanium oxide on the membrane which further generated a cleaner, more easily wettable surface that allows the DNA to go through it more easily. Although graphene-only nanopores can be used for translocating DNA, coating the graphene membranes with a layer of oxide consistently reduced the nanopore noise level and at the same time improved the robustness of the device.

Because of the ultrathin nature of the graphene pores, researchers were able to detect an increase in the magnitude of the translocation signals relative to previous solid state nanopores made in silicon nitride, for similar applied voltages.

The Penn team is now working on improving the overall reliability of these devices and on utilizing the conductivity of the graphene sheet to create devices with transverse electri
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New way to make malaria medicine also first step in finding new antibiotics
2. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
3. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
4. Synaptics to Report First Quarter Results on October 23
5. Alzheimers disease research attracts first partner
6. Volcanoes may have provided sparks and chemistry for first life
7. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
8. Synaptics Reports Record Results for First Quarter of Fiscal 2009
9. First comprehensive genomic study of common cold reveals new treatment targets
10. Scientists achieve first tracking of salmon from headwaters in Rockies through Pacific to Alaska
11. First results from hospital trials testing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First step toward electronic DNA sequencing: Translocation through graphene nanopores
(Date:9/19/2014)... will study multifunctional and specialized spinal cord nerve ... Science Foundation grant in the amount of $680,000 ... in the Department of Biology, OU College of ... between the multifunctional and specialized spinal cord nerve ... what connections they make. Berkowitz will collaborate ...
(Date:9/19/2014)... Inc. (Nasdaq: NXTD and NXTDW) ("Nxt-ID" or the ... updates the "Wocket in Your Pocket" celebrity ad campaign, featuring former ... classes, Vinny Pazienza (PAZ). , ... actor Ciaran Hinds and Sons of Anarchy ... have been cast in Bleed for This . ...
(Date:9/18/2014)... A new GSA Bulletin study uses ... Rio Puerco and Chaco Wash in northern New Mexico, ... salt cedar and willow, investigators were able to precisely ... They then combined this data with aerial imagery, LiDAR, ... of these arroyos. , Arroyos are deep, oversized channels ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7
... and biological aspects of cellular self-organization are well-studied; less ... how their behavior and communication are affected by ... the University of California San Diego, in a paper ... of the National Academy of Sciences, have begun ...
... Japanese researchers were awarded the 2008 SNM Wagner-Torizuka ... States through 2010 as part of the two-year ... Medical College, undertaking a fellowship at Johns Hopkins ... the University of Washington, Seattle; Ryo Nakazato, Toho ...
... has clearly illustrated, the top priority for the next ... Believing that expanding the nation,s commitment to basic ... the next President can take to ensure our long-term ... questions (attached) to the moderator of tomorrow,s presidential debate. ...
Cached Biology News:UC San Diego bioengineers fill holes in science of cellular self-organization 22008 SNM Wagner-Torizuka Fellowships announced 22008 SNM Wagner-Torizuka Fellowships announced 3The Science Coalition's '10 questions' for the presidential debate 2
(Date:9/21/2014)... the University of Basel in Switzerland have succeeded ... charged molecule for the first time. These extremely ... of molecular properties and may also contribute to ... The results were published in the scientific journal ... of the interaction between matter and light, is ...
(Date:9/20/2014)... USA (PRWEB) September 20, 2014 Entries ... 2015 Prism Awards for Photonics Innovation . The ... the multi-billion dollar optics and photonics industry, and is ... and photonics , and Photonics Media . , ... the versatility of photonics, said SPIE CEO Eugene Arthurs. ...
(Date:9/19/2014)...  InterMune, Inc. (Nasdaq: ITMN ) today ... to settle the litigation in the Delaware Court of ... dated as of August 22, 2014, among Roche Holdings, ... term of the Memorandum of Understanding, the Company agreed ... attached exhibit reflecting the amendment to the Company,s Schedule ...
(Date:9/19/2014)... rather than electricity, to move data would consume ... a growing concern as chips, transistor counts rise. ... circuits light emitters, modulators, and detectors ... light source for optical chips is molybdenum disulfide ... as a single, atom-thick layer. Other experimental on-chip ...
Breaking Biology Technology:Uncovering the forbidden side of molecules 2Entry deadline is 10 October for international photonics Prism Awards 2Entry deadline is 10 October for international photonics Prism Awards 3Entry deadline is 10 October for international photonics Prism Awards 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19Toward optical chips 2Toward optical chips 3
... PRINCETON, N.J., May 1 Ranbaxy Pharmaceuticals ... voluntary recall of all lots of Nitrofurantoin (Monohydrate/Macrocrystals) Capsules, ... U.S. Although certain lots of the product were ... laboratory specifications, Ranbaxy decided to recall all the lots, ...
... May 1 /PRNewswire-Asia/ -- Yongye Biotechnology International, Inc. (OTC ... distributor of plant and animal nutrient products located in ... of the independently owned Yongye branded retail stores in ... day sales.A Yongye branded retail store in Qianjiang City ...
... 1 Tigris Pharmaceuticals, Inc., a privately held drug ... a Phase I clinical trial of GGTI-2418. GGTI-2418 ... I) that induces apoptosis by downregulating several pivotal oncogenic ... by Dr. Peter O,Dwyer, Professor of Medicine at the ...
Cached Biology Technology:Yongye Biotechnology Distributor has Record Breaking Single Store Sales Day 2Yongye Biotechnology Distributor has Record Breaking Single Store Sales Day 3First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418 2First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418 3
...
Rabbit polyclonal to SMARCA2 / BRM - ChIP Grade ( Abpromise for all tested applications). entrezGeneID: 6595 SwissProtID: P51531...
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
... These skirted micro test tubes are ... of polypropylene, these tubes have uniform walls ... nonsterile, with separate O-ring screw caps. The ... and have an operating range from -55 ...
Biology Products: