Navigation Links
First partial sequencing of an Iberian pig

Researchers of the Faculty of Veterinary Medicine at Universitat Autnoma de Barcelona (UAB) and of the Centre for Research in Agricultural Genomics (CRAG), the Centre for Genomic Regulation (CRG) in Barcelona, the National Institute for Agrarian Technology and Research in Madrid and Wageningen Research Center (WUR, the Netherlands) have published the first partial genome sequencing of an Iberian pig. Using next-generation sequencing techniques, researchers have been able to sequence and analyse 1% of the genome. This is the first time an individual pig genome-sequence is published. The project, coordinated by ICREA researcher Miguel Prez-Enciso, has been published in the online edition of the journal Heredity.

The sequenced animal is an Iberian sow from the Guadyerbas strain, a highly particular line which has been kept isolated on an experimental farm belonging to the government of Castilla-La Mancha and located in Oropesa, near Toledo, since 1945, thanks to years of work by INIA researchers. The Guadyerbas line thus represents one of the first original strains of the Iberian pig in Spain. These animals have a good appetite, are slow-growing, obese, hairless and black coloured. UAB and INIA teams have used these animals in several experiments aimed at identifying the genetic basis of the highly reputed meat quality of Iberian pigs. Researchers expect therefore that a complete sequencing could offer clues on these and other characteristics.

The sequenced animal is highly inbred, since the herd has been isolated for over 50 years. Researchers have taken this into account with the intention of using a particularly 'homogeneous' species presenting little variability. Nevertheless, data from the sequencing offer surprising results, such as a higher than expected level of variability. Despite being highly inbred, a diversity which represents approximately half of all European populations can be observed. This aspect is important when seen from a conservation viewpoint, since it demonstrates that the Iberian pig is greatly representative of European populations.

Other genome regions present more uniformity and do not have this variability. The sexual chromosome (X) for example is a more uniform than theoretically expected. Comparison between regions of high and low variability offers clues on which genes are more relevant from a selective point of view in the Iberian pig. Among the regions with highest variability there are genes related to the olfactory and immune systems; those presenting less variability are genes related to the metabolism of carbohydrates.

The study of regions that differ most between international lean breeds and Iberian pigs will provide researchers and breeders with information on why Iberian pigs have specific characteristics which make the species unique in terms of their genetics. Before carrying out this detailed analysis, however, the full sequencing and annotation of the pig reference genome must be finished, which will be done by an international consortium. The analysis is foreseen to be completed by the end of the year.


Contact: Maria Jesus Delgado
Universitat Autonoma de Barcelona

Related biology news :

1. World first -- Localized delivery of an anti-cancer drug by remote-controlled microcarriers
2. First census finds surprisingly few white sharks off California
3. First international index developed to predict suicidal behavior
4. In the best youth football teams, the first team players develop their bodies more rapidly
5. BESC scores a first with isobutanol directly from cellulose
6. For first time, scientists show an HIV vaccine impacts the genetic makeup of the virus
7. Canadian researchers first worldwide to generate pluripotent stem cells from horses
8. Erlotinib effective and with fewer side-effects after first-line treatment
9. First harmful algal bloom species genome sequenced
10. Brown tide culprit sequenced: Genome of the first of algal bloom species
11. Clinical Benefits of Zimmers DeNovo® NT Natural Tissue Graft in First Surgery Documented in Peer-Reviewed Publication
Post Your Comments:
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
Breaking Biology Technology: