Navigation Links
First observation of the folding of a nucleic acid
Date:9/21/2010

The prediction of the structure and function of biological macromolecules (i.e., the machinery of life) is of foremost importance in the field of structural biology. Since the elucidation of the three-dimensional structure of DNA (the molecule that carries all genetic information) by Watson and Crick, scientists have strived to decipher the hidden code that determines the evolution of the spatial arrangement of these molecules towards their functional native state. Attempts to follow these structural transitions experimentally and with atomic resolution are hampered by the ultra-fast nature of the folding process. To date, the characterization of these processes by pure computational means has also been very challenging, since monitoring the folding of nucleic acid with realistic methods requires years of computing time in a regular PC.

The researchers Modesto Orozco, Life Sciences Director of the Barcelona Supercomputing Center and responsible of the Molecular Modelling and Bioinformatics group at the Institute for Research in Biomedicine (IRB Barcelona), and Guillem Portella, postdoctoral researcher of his group, have been able to describe for the first time the folding process of a small DNA hairpin in water and with atomic resolution. The study reveals that, unexpectedly, the folding process appears as a competition between different fast folding and slow folding routes, and that microscopic details determine in a random fashion which route is explored. This investigation, conducted by means of molecular dynamics techniques, has been possible thanks to the enormous computing power of the MareNostrum supercomputer.

The present study has far-reaching implications not only because it represents a new milestone in the theoretical study of nucleic acids' folding, but also it is of great importance for the design of new therapeutic strategies based on oligonucleotides. This is the case, e.g., for RNA interference based treatments, which will
'/>"/>

Contact: Sara Ibanez
sara.ibanez@bsc.es
34-934-137-514
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Page: 1 2

Related biology news :

1. New way to make malaria medicine also first step in finding new antibiotics
2. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
3. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
4. Synaptics to Report First Quarter Results on October 23
5. Alzheimers disease research attracts first partner
6. Volcanoes may have provided sparks and chemistry for first life
7. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
8. Synaptics Reports Record Results for First Quarter of Fiscal 2009
9. First comprehensive genomic study of common cold reveals new treatment targets
10. Scientists achieve first tracking of salmon from headwaters in Rockies through Pacific to Alaska
11. First results from hospital trials testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
(Date:3/31/2015)... , March 31, 2015   Guidepoint , a ... of the Post-Surgical Pain Management TRACKER, part of the ... usage trends in the medical device and therapeutics markets. ... data including treatment volumes, market share, and adoption rates ... associated with joint surgery. The Post-Surgical Pain ...
(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... members should play a key role in nutrition and health ... are often overlooked by health organisations that don,t understand the ... to promoting good nutrition and health practices. Those are ... the January issue of Maternal and Child Nutrition. ...
... release is available in German . , ... time that laypeople have always known: the mere sight of ... men has documented that the amount of the neurosecretory protein ... visual stimulation through images of food. As a main regulator, ...
... R.I. [Brown University] Although there is an effective vaccine ... sense of who is at highest risk for the infectious ... States contract the virus every year. According to a new ... the vaccine continue to be a reason why infections persist. ...
Cached Biology News:Research highlights key role grandmothers play in mother and child nutrition and health 2Research highlights key role grandmothers play in mother and child nutrition and health 3Pictures of food create feelings of hunger 2Many high-risk Americans don't get hepatitis B vaccine 2Many high-risk Americans don't get hepatitis B vaccine 3
(Date:4/30/2015)... 30, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... that it has commenced an underwritten public offering of ... the underwriters a 30-day option to purchase up to ... stock offered in the public offering. The offering is ... assurance as to whether or when the offering may ...
(Date:4/30/2015)...  The Paul G. Allen Family Foundation announced today ... six groups of researchers with projects at the frontier ... growing mature human brain cells in the laboratory. The ... over three years.  "This new cohort ... significant because the field of neuronal maturation is at ...
(Date:4/30/2015)... FRANCE (PRWEB) April 30, 2015 ... and at http://www.lespausa.com , Fleur’s ... multi-action product combining the benefits of makeup, skin ... This subtly tinted cream is designed with specific ... for an even complexion and a healthy glow. ...
(Date:4/29/2015)... According to a new market research report ... Non-Portable), Component (Accelerometer, Proximity Probe, & Others), Application ... & Others), & Geography - Global Forecast to ... $1,453.76 Million by 2020, at a CAGR of ... 92 figures spread through 205 pages and in-depth ...
Breaking Biology Technology:BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4
... materials scientist at Michigan Technological University has discovered a chemical ... dioxide, it also creates something useful. And, by the way, ... nothing new, but carbon dioxide molecules are so stable that ... that energy were to come from fossil fuels, over time ...
... The Houston Technology Center (HTC), Texas, ... gala, "A Celebration of Entrepreneurs . "  The ... impact on the region,s economy; and developed lifesaving and ... Beth Williams, CEO of TechTrans International, Inc., as this ...
... Champions Oncology Inc. (OTC: CSBR) announced today that ... certification from the Maryland Department of Health and Mental ... company to conduct medical laboratory tests. ... approval is a significant milestone for our Company. This ...
Cached Biology Technology:Leading Technology Incubator Honors Extraordinary Entrepreneurs 2Leading Technology Incubator Honors Extraordinary Entrepreneurs 3Champions Oncology Inc. Receives Approval from U.S. Regulatory Authorities 2Champions Oncology Inc. Receives Approval from U.S. Regulatory Authorities 3
... Capillary Electrophoresis Running Buffer was designed to ... demands of todays sequencing labs. As a ... to the gel-based sequencing community Sigma has ... to meet your buffer needs. Scientists at ...
... The ProteomeLab PA 800 is ... Part of Beckman Coulters ProteomeLab ... offers a comprehensive range of automated ... determination, peptide mapping, isoelectric focusing, carbohydrate ...
... were designed for full-length gene cloning and ... identify the desired cDNA clone. The first ... "Master Plate," where each well contains plasmid ... positive well(s) by gel electrophoresis of the ...
... Jobin Yvons Protein 295 ex can measure ... sample in only a few minutes. To ... acids tyrosine and tryptophan, the Protein 295 ... a pulsed diode emitting 295 nm. Fluorescence ...
Biology Products: