Navigation Links
First individual genome sequence published
Date:9/3/2007

ns (indels), copy number variants, block substitutions, and segmental duplications. While the SNPs outnumbered the non-SNP types of variants, the non-SNP variants involved a larger portion of the genome. This suggests that human-to-human variation is much greater than previously thought. The researchers suggest that much more research needs to be done on these non-SNP variants to better understand their role in individual genomics.

According to Sam Levy, Ph.D., lead author and senior scientist at JCVI, The ability to use unbiased, high throughput sequencing methods, coupled with advance computational analytic methods, enables us to characterize more comprehensively the wide variety of individual genetic variation. This offers us an unprecedented opportunity to study the prevalence and impact of these DNA variants on traits and diseases in human populations.

Another important feature that is made possible by having an individual, diploid genome is the ability to begin to do better and more informed haplotype assemblies. Haplotypes are groups of linked variants. Through the government-sponsored HapMap project, many common haplotypes have been identified; however, these are based on averages of large ethnogeographic populations rather than individuals. Having individual haplotypes would enable researchers to understand and find more rare or individual variants that would explain and help predict diseases in that particular persona truly personalized, individualized genomics paradigm. In the HuRef analysis, the team used the 4.1 million variant set and new algorithms to build haplotype assemblies that, when compared to the HapMap project, represented longer and more complete linkages. The JCVI researchers expect this number to improve significantly as additional sequence coverage is added to HuRef using a variety of new seque ncing technologies.

Long-range haplotype linkages will enable much more complete analysis of human variation and the
'/>"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. A genes first kiss sets off that affair known as puberty
2. Timing is everything: First step in protein building revealed
3. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
6. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Love at first smell
9. Worlds largest rainforest drying experiment completes first phase
10. PCRM develops worlds first cruelty-free insulin assay
11. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( ... "Global Iris Recognition Market 2015-2019" report to their ... Recognition market to grow at a CAGR of 23.5 ... covers the present scenario and the growth prospects of ... To calculate the market size, the report considers the ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... and Voice Biometrics - Global Strategic Business Report" report to ... Face and Voice Biometrics in US$ Thousands by the following Segments: ... for the US, Canada , Japan ... , Middle East & Africa ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... /PRNewswire-iReach/ -- Vyzin, Inc. announced today it has passed ... ROHS and SAR certifications for its mobile health (mHealth) ... VESAG mobile-based personal emergency response system (MPERS) is ... of patient vitals without the need to see a ...
... omega-3 fatty acid supplements can lower inflammation in healthy, ... use of these supplements could help protect against and ... decreased one protein in the blood that signals the ... 10 percent, and led to a modest decrease in ...
... of shapes and sizes, forming a thick inter-connected jungle of ... simple pattern that describes the tree-like shape of all neurons. ... other cells with many branches that effectively act like wires ... thought and action. Over 100 years ago, Santiago Ramon ...
Cached Biology News:VESAG mHealth watch awarded CE, ROHS and SAR certifications 2Omega-3 lowers inflammation in overweight older adults 2Omega-3 lowers inflammation in overweight older adults 3Omega-3 lowers inflammation in overweight older adults 4Simple mathematcal pattern describes shape of neuron 'jungle' 2
(Date:3/27/2015)... -- WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... platform company serving the global pharmaceutical, biotechnology, and ... New Drug (IND) application for WuXi MedImmune,s novel ... accepted for review by the China Food and ... 2012, MedImmune, the global biologics research and development ...
(Date:3/27/2015)... -- CASI Pharmaceuticals, Inc. (Nasdaq: CASI ), a biopharmaceutical ... innovative therapeutics addressing cancer and other unmet medical needs ... China , today reported financial results ... 2014.  The Company reported a net ... the three months ended December 31, 2014.  This compares ...
(Date:3/27/2015)... Buffalo, New York (PRWEB) March 27, 2015 ... of the 2015 application period for 43North - the ... cash prizes, including a grand prize of $1 million, ... attracts entrepreneurs from around the world to compete for ... into funded enterprises in the Western New York region. ...
(Date:3/26/2015)... 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of ... the three months and full year ended December ... Results:Revenue for the quarter ended December 31, 2014 ... fourth quarter of 2013 and $1.5 million for ...
Breaking Biology Technology:Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7
... for Recovery of siRNA and miRNA , ... Small RNA, mRNA, and Protein , Ambion's ... <A , href="http://www.ambion.com/catalog/CatNum.php?1560">mir ... href="http://www.ambion.com/catalog/CatNum.php?">Vana , miRNA Isolation Kit , optimized for small RNA recovery, and the ...
... , Amplifies as little as ... , High Percent Present Calls and low , ... M-MLV RT engineered to maximize yields of full-length , ... available , ...
... The MEGAscript Kit ... cited large-scale transcription kit, and with good , ... of full-length RNA (Figure 1). Ambion offers a complete line , ... , products: , ...
Cached Biology Technology:Isolate Total RNA and Protein From the Same Sample 2Isolate Total RNA and Protein From the Same Sample 3Isolate Total RNA and Protein From the Same Sample 4Isolate Total RNA and Protein From the Same Sample 5MessageAmp II: Use Less RNA for Array Analysis 2MessageAmp II: Use Less RNA for Array Analysis 3MessageAmp II: Use Less RNA for Array Analysis 4MessageAmp II: Use Less RNA for Array Analysis 5MessageAmp II: Use Less RNA for Array Analysis 6MessageAmp II: Use Less RNA for Array Analysis 7High Yield Transcription for Every Application 2High Yield Transcription for Every Application 3High Yield Transcription for Every Application 4High Yield Transcription for Every Application 5
The BD CBA Human Apoptosis Kit can be used to quantitatively measure,cleaved PARP, Bcl-2, and active Caspase-3 protein levels in a single sample. The,Kit performance has been optimized for analysis o...
... package that provides crystallographers with an ... creation, set-up of experimental conditions and ... software helps crystallographers through the most ... Design of Crystallization ...
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... plate, Directly compatible with ABI thermal cyclers, ... improved sealing characteristics can be sealed ... cap strips, Certified free of DNase, RNase ... of Thermo Fisher Scientific, the world leader ...
Biology Products: