Navigation Links
First-in-man study demonstrates the therapeutic effect of RNAi gene silencing in cancer treatment
Date:2/11/2013

The new study published in Cancer Discovery, the flagship journal of the American Association of Cancer Research (AACR), involving three Spanish and six American research centres, presents significant results in treating cancer patients with nanoparticles containing ribonucleic acid interference (RNAi) molecules. This marks the first time that the therapeutic effect of RNAi has been demonstrated in humans.

Barcelona, 11 February 2013. A study led by Dr Josep Tabernero, the Director of Clinical Research at the Vall d'Hebron Institute of Oncology (VHIO) and Head of the Medical Oncology Department at the Vall d'Hebron University Hospital, shows for the first time that ribonucleic acid interference (RNAi) is effective in the treatment of cancer patients. Harnessing these molecules to silence genes involved in the development and growth of cancer cells is an important step forward in developing a new and more targeted type of cancer therapy.

Dr Josep Tabernero, lead author of this study, said: "This is the first evidence to show that RNAi can be administered to cancer patients effectively, leading to significant tumour response."

RNAi is a gene-silencing mechanism that uses a subtype of RNA molecules to interfere with and silence genes. RNAi plays a vital role in normal cell development and differentiation, in cancer and viral defence, as it is powerful mechanism in the regulation of gene expression. Besides being a key natural cellular phenomenon, gene silencing shows great potential as a therapeutic device to shut down genes that have become hyperactive through cancer.

However, researchers have encountered difficulties in administering RNAi, as the molecules must penetrate cells in therapeutically effective concentrations, which in turn requires structural modifications. In the new study, led by the Vall d'Hebron Institute of Oncology (VHIO), along with several other cancer research centres and the U.S. biotech comp
'/>"/>

Contact: Amanda Wren
awren@vhio.net
34-695-207-886
Vall dHebron Institute of Oncology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Studying bed bug actions for new management tactics
2. Study identifies liver gene that regulates cholesterol and fat blood levels
3. Study shows disease spread in ladybirds with sexually transmitted disease
4. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
5. Study of a rare disease making people look like a woman but having male genitals under study
6. Study finds potential to match tumors with known cancer drugs
7. Can plants be altruistic? You bet, says new CU-Boulder-led study
8. New study sheds light on link between dairy intake and bone health
9. Medical societies to launch large-scale study on vein filter use
10. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
11. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... ALBANY, New York , July 7, 2014 /PRNewswire/ ... published by Transparency Market Research "Electronic Access Control Systems ... Analysis, 2014 - 2019," the global Electronic Access Control ... 2013 and is expected to grow at a CAGR ... estimated value of USD 31,187.8 million in 2019. ...
(Date:7/10/2014)... 2014  Acuity Market Intelligence today released forecasts from "The ... that the global market for National Electronic ID (eID) programs ... During this time, the number of National eID cards in ... Asia , with its vast population, will dominate ... issued, while Europe trails a distant ...
(Date:7/10/2014)... genus Axinaea belongs to the large, mainly tropical ... ca. 5000 species in the family rely on bees for ... by other insects or vertebrates. The flowers of Axinaea ... flowers and the petals of the different species are pink, ... out based on the contrasting colours of their bulbous appendages. ...
Breaking Biology News(10 mins):Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2Novel type of bird pollination mechanism discovered in South America 2
... detection methods, researchers at the Saint Louis University Institute ... by which the HIV virus infects, or integrates, healthy ... for HIV. , Although scientists theorized that two ends ... healthy cell in order to infect it, until now, ...
... like other biological attributes, is shaped by evolution ... species that are in other ways very similar ... the visual world slightly differently, using photoreceptors that ... studying a special group of closely-related fish species ...
... stroke has taken a major step forward following promising results ... of Manchester have shown in laboratory studies that a naturally ... death. , The team, led by Professor Nancy Rothwell and ... first small trial of IL-1ra in patients, which are published ...
Cached Biology News:SLU researchers uncover direct evidence on how HIV invades healthy cells 2Multiple genes permit closely related fish species to mix and match their color vision 2Stroke treatment a step closer after trial 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
(Date:7/10/2014)... -- Kainos Capital, a firm specializing in acquiring and managing ... acquired the Slim-Fast brand from Unilever. Unilever will retain ... transaction were not disclosed. Slim-Fast is a ... ready-to-drink shakes, powders, bars and snacks to retail customers ... the United Kingdom and Ireland.  ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... that power our laptops and electric vehicles could store ... with the help of a sponge-like silicon material. ... graphite traditionally used in one of the battery,s electrodes, ... storage capacity of graphite. A paper describing the material,s ... in Nature Communications . , "Silicon has long ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... , , , ... Board: SYMD), a biomaterials company engaged in the development ... the company,s bioresorbable adhesion barrier film for the reduction ... the Brazilian Ministry of Health for use in all ...
... DURHAM, N.C., Sept. 9 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: ... asks shareholders to approve a 1-for-15 reverse stock split at the ... "At last years, general annual meeting we explained the problems of ... promised to seek a listing change as soon as we can ...
... MUMBAI, India, September 9 , ... its First Domain-Specific Learning,and Consulting Solutions for Health Care ... Interactive Systems (TIS)-has,recently announced the launch of its first ... industry. TIS formally,launched this initiative with the appointment of ...
Cached Biology Technology:SyntheMed Receives Brazilian Regulatory Approval for REPEL-CV(TM) 2Oxygen Biotherapeutics, Inc. Seeks Shareholder Approval for Reverse Stock Split 2Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 2Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 3Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 4
... is the major proteolytic system in ... it catalyzes the selective degradation of ... elimination of proteins with abnormal conformation ... The critical protease in this pathway ...
... [1320] to RFC1 Immunogen Recombinant protein ... Factor C expressed in E. coli. Reactivity ... cerevisiae. Not yet tested in other species. This ... Background Information Replication factor C is ...
... Bacterial DNA Isolation Kit provides a rapid ... genomic DNA from the various bacterial species ... the isolation of genomic DNA from both ... milk samples. ,Purification is based on ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Biology Products: