Navigation Links
First-in-class treatment for acute leukemia
Date:12/8/2009

generate it, and developed the methodology to validate it.

Stimulating the patient's own immune response

At the start of the project in 2003, Innate Pharma had already identified a new generation of protein molecules able to stimulate NK cells through their specific receptors, unaffected by the activity of cancerous or infected cells which would normally suppress an immune response. On this basis, Innate Pharma and Novo Nordisk set out to discover candidate therapeutic molecules suitable for administration to humans.

A few suitable proteins were selected and taken through initial drug characterisation. The most promising candidate was identified and Novo Nordisk then supported the regulatory evaluation, pre-clinical and Phase I clinical trials for safety and dose testing. By the end of the EUREKA sponsorship (at the end of 2006), the Danish company had produced the drug in a form that could be administered to patients for safety and efficacy evaluation in Phase I and II trials. Innate Pharma is now continuing the trials toward market authorisation; anticipated to be within 6 years.

Fast and promising development

The identification of the new potential drug was very fast. "We did not need to look at many alternative candidates," says Nicolai Wagtmann, Vice President at Novo Nordisk, who led the project through the discovery phase. "This was not a traditional massive drug screen, but quite the opposite. We started from an understanding of the disease and the biological mechanism effective in transplantation, the precise molecule in the body that we wanted to modify, and a clear idea of how that had to be done."

As well as testing the potential new drug as a treatment for acute myeloid leukaemia, it is being examined for activity against the chronic form of the disease and it may also have applications in treatment of other forms of cancer, e.g. lymphoma and melanoma. Nicolai Wagtmann comments: "I
'/>"/>

Contact: Francois Romagn
Francois.Romagne@innate-pharma.fr
33-430-303-030
EUREKA
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Nicotinic receptors may be important targets for treatment of multiple addictions
2. A new radiation therapy treatment developed for head and neck cancer patients
3. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
4. Presence of gene mutation helps guide thyroid cancer treatment
5. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
6. New genetic research into nicotine addiction shows promise for personalized treatment
7. Interleukin-8, key marker for colorectal cancer treatment
8. New class of drug offers hope to treatment-resistant AIDS patients
9. Paradigm shift in Alzheimerss research: new treatments
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... , May 7, 2015 ... sensors, FPC1022 and FPC1035, FPC,s smallest touch fingerprint ... are mainly considered for integration on the backside ... smartphone OEMs increased possibilities to integrate touch fingerprint ... size also improves possibilities for module manufacturers to ...
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
(Date:4/21/2015)... BURNABY, Canada , April 21, 2015 ... spending and evolving government policies are boosting access control ...   According to a recently published report ... & Opportunities, 2020 ", the access control systems market ... to nearly USD1.2 billion by 2020.The access control systems ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... a glance, DNA is a rather simple sequence of A, ... histone proteins into an amalgam called chromatin, a more complex ... and H4can either coil DNA into inaccessible silent regions or ... small chemical flags, such as methyl groups, affect whether histones ...
... as they grow older, according to a new study in ... growth accelerates as they age suggests that large, old trees ... the atmosphere. , Richard Condit, staff scientist at the ... from more than 600,000 trees belonging to 403 species. "Rather ...
... one of the most deadly infectious diseases in the world ... every year, and the recent emergence of parasites resistant to ... Researchers are now onto a new strategy to defeat drug-resistant ... ACS Chemical Biology . Christine Hrycyna, Rowena ...
Cached Biology News:Next-gen reappraisal of interactions within a cancer-associated protein complex 2Next-gen reappraisal of interactions within a cancer-associated protein complex 3
(Date:6/2/2015)... June 2, 2015   Intrexon Corporation ... biology, announced today the appointment of Olivier ... Consumer Sector.  Mr. Jarry will lead the expansion ... and applications for consumer markets.  ... of experience in leading global life sciences and ...
(Date:6/2/2015)... June 2, 2015  RXi Pharmaceuticals Corporation ... focused on discovering and developing innovative therapies ... ophthalmology, today announced that Dr. Pamela Pavco ... at the 23 rd World Congress ... will include in-depth presentations by world-class clinicians ...
(Date:6/2/2015)...  Alere Inc. (NYSE: ALR ), a ... House Antibiotic Stewardship Forum today to announce a ... the President,s National Action Plan to Combat Antibiotic-Resistant ... measurable goals and objectives over the next five ... protect their patients through antibiotic stewardship, slow the ...
(Date:6/2/2015)... Junction, AZ (PRWEB) June 02, 2015 ... light microscope technology, Yancy Corporation is enabling ... any desired material and biological sample, displaying the full ... electron bonds between atoms. , Jeff Porter, Co-Founder of ... physics are just that – rare. They come once ...
Breaking Biology Technology:Intrexon Announces New Sector Leader 2Intrexon Announces New Sector Leader 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4Alere Announces Broad Initiatives to Help Combat Antibiotic Resistance during White House Antibiotic Stewardship Forum 2Scientists Eying Rare Discovery Of New Physics & Light Microscope Technology 2
... featured in oral presentation ... TSX Exchange Symbol: ... is pleased to announce that tomorrow it is making,an oral ... at the International Atherosclerosis Society (IAS),Workshop on HDL. The presentation ...
... A hybrid device combining force and fluorescence developed ... possible the accurate detection of nanometer-scale motion of biomolecules ... energy transfer and an optical trap, we now have ... a biomolecule at an extremely low applied force, said ...
... IRVINE, California, October 11 IsoTis, Inc.,(NASDAQ: ISOT ... adjourned the special meeting of stockholders it called to ... IART ) ("Integra") pursuant to an agreement and ... The special meeting of stockholders was held at 9 ...
Cached Biology Technology:Resverlogix is Presenting at IAS HDL Workshop 2New force-fluorescence device measures motion previously undetectable 2New force-fluorescence device measures motion previously undetectable 3IsoTis Adjourns Special Meeting to October 23, 2007 2IsoTis Adjourns Special Meeting to October 23, 2007 3IsoTis Adjourns Special Meeting to October 23, 2007 4