Navigation Links
First human gets new antibody aimed at rabies virus
Date:9/30/2009

Boston, Mass. MassBiologics of the University of Massachusetts Medical School today announced the beginning of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody (MAB) developed to neutralize the rabies virus.

The clinical trial is being conducted at the King Edward Memorial Hospital in Mumbai, India, and is sponsored by the Serum Institute of India, which is working in a collaborative partnership with MassBiologics to manufacture and test the new antibody.

"India is an appropriate location to do this study because of the serious problem of rabies that exists in the country," said Donna Ambrosino, MD, executive director of MassBiologics and a professor of pediatrics at the Medical School. "We look forward to seeing the results from this trial, and to advancing this potentially life-saving treatment."

Even though rabies-related deaths in the United States are rare, more than 40,000 people in the U.S. are exposed to the disease each year and require immediate treatment known as post-exposure prophylaxis (PEP). Worldwide, however, rabies remains a major public health problem. The World Health Organization estimates that at least 10 million people are exposed to rabid animals each year, resulting in some 55,000 deaths.

The rabies virus can cause acute encephalitis that is fatal once symptoms appear; however the infection is preventable by prompt treatment following exposure. By using a rabies vaccine and human rabies immune globulin (hRIG) soon after exposure, patients are protected from the fatal disease. Unfortunately, hRIG, which is derived from human blood, is an expensive material and is often not available in developing countries. To compensate, equine immune globulin derived from horse serum is used in many parts of the world, but it also can be scarce and it can carry significant side effects.

To address the supply problems and side-effect issues, MassBiologics and the U.S. Centers for Disease Control and Prevention launched an effort to develop a MAB that could be used in place of hRIG. The research used, in part, HuMab mice from Medarex, Inc. (Princeton, N.J.) which are transgenic mice able to produce fully human antibodies. Pre-clinical testing of the new MAB showed that it neutralized all isolates available from a panel of rabies viruses.

"Too often physicians in India and other developing countries only have the rabies vaccine to offer, and that alone isn't always enough to prevent infection," said Deborah Molrine, MD, deputy director of clinical and regulatory affairs at MassBiologics and an associate professor of pediatrics at the Medical School, who helped design the clinical trial and will oversee the analysis. "If this new antibody proves effective in people, it will have a tremendous impact on saving lives."

In the Phase 1 trial just launched in India, a total of 84 healthy volunteers will receive various doses of the new MAB to test the tolerability and biologic activity of the MAB in people. The site investigators will monitor the volunteers' overall health and do clinical laboratory testing for safety. Scientists at MassBiologics will test blood samples drawn from the volunteers to measure the amount of MAB in the bloodstream, and to see if the volunteers produced any of their own antibodies directed against the new MAB. Scientists from the Kansas State Veterinary Diagnostic Laboratory will test the blood samples against the rabies virus in culture, to determine the dose of MAB administered to the volunteers that gave the best protective response.

The Serum Institute of India is the world's largest manufacturer of vaccines and is a major supplier of the rabies vaccine. Scientists from the MassBiologics worked with their counterparts in India to help the Serum Institute build its own internal MAB production facility, thereby bringing this leading-edge biologics technology to India for the first time.


'/>"/>

Contact: Michael Cohen
Michael.Cohen@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Related biology news :

1. Spallation Neutron Source first of its kind to reach megawatt power
2. NSF funds states first imaging system for UAB microscale research lab
3. Yale engineers track bacterias kayak paddle-like motion for first time
4. Stem cell applications and research highlight NJITs first Research Cafe
5. Research team finds first evolutionary branching for bilateral animals
6. IRSF announces funding of first clinical trial with disease-modifying therapy for Rett syndrome
7. Young age at first drink may affect genes and risk for alcoholism
8. ESHREs first workshop on male infertility in Thessaloniki
9. Secrets in a seed: Clues into the evolution of the first flowers
10. Scientists use microRNAs to track evolutionary history for first time
11. Researchers find first evidence of virus in malignant prostate cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... YORK , March 9, 2016 This ... and future states of the RNA Sequencing (RNA Seq) ... segments such as instruments, tools and reagents, data analysis, ... Analyze various segments of the RNA-Sequencing market such as ... services Identify the main factors affecting each segment and ...
(Date:3/8/2016)... , March 8, 2016   Valencell ... technology, today announced it has secured $11M in ... GII Tech, a new venture fund being launched ... additional participation from existing investors TDF Ventures and ... funds to continue its triple-digit growth and accelerate ...
(Date:3/3/2016)... and DE SOTO, Kansas ... U.S.-based Stroke Detection Plus® to offer Oncimmune,s Early ... assessment and early detection of lung cancer ... employers, unions and individuals. --> Early CDT®-Lung ... and individuals. --> Oncimmune, a leader in ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... 19, 2016 - I dati ... durante il 52 ° Congresso ... - Le conclusioni dello studio indicano un ... trattati, di cui il 90% presenta una d urata ... più. Il settantadue per cento dei pazienti ha riscontrato un ...
(Date:5/18/2016)... The Biotech industry continues to face a wave ... no opportunities ahead. Today, ActiveWallSt.com has on its list these ... Seattle Genetics Inc. (NASDAQ: SGEN ), Chiasma Inc. ... OPHT ). Sign up now to receive our free ... Threshold Pharmaceuticals Inc.,s shares gained 0.68%, closing Tuesday,s ...
(Date:5/18/2016)... IN (PRWEB) , ... May 18, 2016 , ... The ... and is now celebrating its dream of reaching a total of $1 million in ... scholarships awarded to 10 high school graduates from across the nation has helped bring ...
(Date:5/17/2016)... ... May 17, 2016 , ... ... animal waste reduction applications, announced today it will be showcasing ManureMagicâ„¢ at booth ... ManureMagicâ„¢ was featured in the Wall Street Journal last year and more recently ...
Breaking Biology Technology: