Navigation Links
First genetically-engineered malaria vaccine to enter human trials
Date:7/28/2009

d Army Institute for Research and the University of Maryland, had used knowledge from several decades ago when scientists proved that irradiated malaria parasites provide protection against subsequent malaria infection in animal models and humans in developing the vaccine.

"Although vaccines are under development that use whole malaria parasites weakened by irradiation to protect against infection, their safety and effectiveness rely on a precise irradiation dose and trial results have been variable," Professor Cowman said. "We believe that our genetically attenuated parasite approach provides a safe and reproducible way of developing a whole organism malaria vaccine."

Professor Cowman said it was unlikely the weakened parasites used in the vaccine would regain their potency as the genes had been deleted from the genome and could not be recreated by the parasite. "In addition, the 'one-two punch' approach of deleting two essential genes make it extremely unlikely that the attenuated parasite vaccine could restore its capacity to multiply and lead to disease," he said.

The human trials of the vaccine will take place at the Walter Reed Army Institute of Research in Maryland, US. The genetically attenuated parasites to be used in the trial are being manufactured at the Walter and Eliza Hall Institute, which has the only facility worldwide capable of producing genetically-altered malaria parasites that comply with the good manufacturing practice guidelines required for human clinical trials.


'/>"/>

Contact: Ms Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Spallation Neutron Source sees first target replacement
2. Results of national assessment of first responder location systems to be announced Aug. 3
3. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
4. Researchers design first model motor nerve system thats insulated and organized like the human body
5. Our brain looks at eyes first to identify a face
6. Scientists report first remote, underwater detection of harmful algae, toxins
7. First cGMP feeder-independent pluripotent stem cell banks released for distribution
8. Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
9. First direct evidence of substantial fish consumption by early modern humans in China
10. Ovarian transplantation: First baby is born after a new technique
11. First riser-drilling research operations undertaken
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First genetically-engineered malaria vaccine to enter human trials
(Date:8/12/2015)... Florida , August 12, 2015 ... pace of mobile payment innovation and advanced biometrics technology ... replace the way consumers rely on using their credit ... with reinventing the future for payment services led by ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ...
(Date:8/10/2015)... , August 10, 2015 ... Eye Tracking Technology for more than two decades, announces ... for integration into all consumer display formats. The SMI ... integration of eye tracking into consumer tablets, laptops, desktop ... smart glasses. Omnivision,s leading sensor technology contributes to the ...
(Date:8/6/2015)... Calif. , Aug. 6, 2015 ... developer of human interface solutions, today announced collaboration ... technologies on Windows 10. Microsoft leveraged Synaptics, deep ... the operating system. Through stringent ... are fully certified with Microsoft,s Precision TouchPad (PTP) ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Synaptics Chosen for Human Interface Co-Development on Windows 10 2
... of continental drift provides a good model for understanding terrestrial ... successfully shed light on processes up to 3 billion years ... the earth and crust formation before that point and through ... ago. This is the conclusion of Tomas Naraa of the ...
... tissue using cells derived from the amniotic fluid is ... UCL Institute of Child Health. The paper ... cells derived from the fluids which surround the fetus ... The treatment resulted in longer survival in mice affected ...
... Inc., a Los Angeles based investment banking company, today ... Alliqua, Inc.  During the term of the engagement, WestPark ... and finance, private and public equity and debt financing, ... provide introductions to investors. About Alliqua, ...
Cached Biology News:New understanding of terrestrial formation has significant and far reaching future implications 2Potential new approach to regenerating skeletal muscle tissue 2WestPark Capital, Inc. Engaged By Alliqua, Inc. 2
(Date:8/31/2015)... ... August 31, 2015 , ... Proove Biosciences, Inc. is a finalist for ... High Tech Awards. , Now in its 22nd year, this premier awards event celebrates ... across the nation and around the world. The OC Tech Alliance will announce all ...
(Date:8/28/2015)... August 28, 2015 According to ... Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by Biospecimen ... Clinical Trials), End User - Global Forecast to 2020", ... to reach USD 3,731.03 Million by 2020 from USD ... 11.65% between 2015 and 2020. Browse ...
(Date:8/28/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) ... on the development of autologous cell therapies, today ... 30, 2015, corporate highlights, and near-term milestones.  The ... at www.sedar.com ,  www.edgar.com and ... expects to launch its RCS-01 treatment for aging ...
(Date:8/27/2015)... ... August 27, 2015 , ... ... capital funds, investment firms and animal health companies to hear from animal health ... million. Several have also received licensing agreements or distribution contracts. This meeting ...
Breaking Biology Technology:Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 2Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 3Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 4Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3
... This release is available in German . When ... light particles, so-called photons, carry sufficient energy, the electrons can be ... was explained by Einstein more than hundred years ago. Until now, ... the atom immediately after the impact of the photon. This point ...
... ... case study that provides a sustainable solution for odor and pathogen ... of beneficial microbial applications. These results are intended to address the ... who recently agreed to identify and investigate thousands of factory farms ...
... ... in Latin America regarding approvals of Stemedica’s allogeneic adult stem cell products for use in ... , ... 24, 2010 -- Stemedica Cell Technologies, Inc., a leader in allogeneic adult stem ...
Cached Biology Technology:Delayed time zero in photoemission 2Delayed time zero in photoemission 3Effective Odor and Pathogen Control in Livestock Operations Revealed in New Case Study 2Stemedica Announces the Appointment of Dr. Csar Amescua Garcia as Medical and Regulatory Affairs Director – Latin America 2
...
... 220 utilizes utilizies CTI Molecular Imaging's ... superior resolution, sensitivty, and a large ... the flexibility to image multiple mice ... microPET is a dedicated small animal ...
... StatMatic I provides a convenient and affordable ... work. Used with an eight-port disposable manifold, ... possible with multi-channel pipettes. The eight-port manifold, ... volumes of 100, 200, 250, or 300mL ...
... HRP Stabilizing Diluent (MOPS Buffered) has ... Horseradish Peroxidase conjugates in solution. HRP ... and maintains the conformation of the antibody ... Product is filtered at 0.2 microns., ...
Biology Products: