Navigation Links
First genetically-engineered malaria vaccine to enter human trials
Date:7/28/2009

Walter and Eliza Hall Institute scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year.

Malaria kills more than one million people each year and destroys through premature death and disability the equivalent of at least 35 million years of healthy, productive human life every year.

Professor Alan Cowman, head of the institute's Infection and Immunity division, said in developing the vaccine the research team had deleted two key genes in the Plasmodium falciparum parasite which causes the form of malaria most deadly to humans. By removing the genes the malaria parasite is halted during its liver infection phase, preventing it from spreading to the blood stream where it can cause severe disease and death.

Their success in genetically modifying the parasite and thereby preventing its invasion of red blood cells is published in the current issue of the Proceedings of the National Academy of Sciences USA.

Professor Cowman said similar vaccines had been tested in mice and offered 100 per cent protection against malaria infection. He said it was hoped the vaccine would produce similar results in humans. "Although two genes have been deleted the parasite is still alive and able to stimulate the body's protective immune system to recognize and destroy incoming mosquito-transmitted deadly parasites," Professor Cowman said.

This approach to vaccine development using a weakened form of the whole organism that causes a particular disease has proven successful in eradicating smallpox and controlling diseases such as flu and polio.

Professor Cowman said the research team, which includes Dr Matthew O'Neill and Dr Alex Maier from the institute as well as scientists from the Seattle Biomedical Research Institute, the Walter Reed Army Institute for Research and the University of Maryland, had used knowledge from several decades ago when scientists proved that irradiated malaria parasites provide protection against subsequent malaria infection in animal models and humans in developing the vaccine.

"Although vaccines are under development that use whole malaria parasites weakened by irradiation to protect against infection, their safety and effectiveness rely on a precise irradiation dose and trial results have been variable," Professor Cowman said. "We believe that our genetically attenuated parasite approach provides a safe and reproducible way of developing a whole organism malaria vaccine."

Professor Cowman said it was unlikely the weakened parasites used in the vaccine would regain their potency as the genes had been deleted from the genome and could not be recreated by the parasite. "In addition, the 'one-two punch' approach of deleting two essential genes make it extremely unlikely that the attenuated parasite vaccine could restore its capacity to multiply and lead to disease," he said.

The human trials of the vaccine will take place at the Walter Reed Army Institute of Research in Maryland, US. The genetically attenuated parasites to be used in the trial are being manufactured at the Walter and Eliza Hall Institute, which has the only facility worldwide capable of producing genetically-altered malaria parasites that comply with the good manufacturing practice guidelines required for human clinical trials.


'/>"/>

Contact: Ms Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Spallation Neutron Source sees first target replacement
2. Results of national assessment of first responder location systems to be announced Aug. 3
3. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
4. Researchers design first model motor nerve system thats insulated and organized like the human body
5. Our brain looks at eyes first to identify a face
6. Scientists report first remote, underwater detection of harmful algae, toxins
7. First cGMP feeder-independent pluripotent stem cell banks released for distribution
8. Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
9. First direct evidence of substantial fish consumption by early modern humans in China
10. Ovarian transplantation: First baby is born after a new technique
11. First riser-drilling research operations undertaken
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First genetically-engineered malaria vaccine to enter human trials
(Date:2/6/2017)... According to Acuity Market Intelligence, ongoing ... to continue to embrace biometric and digital identification ... Border Control (ABC) eGates and 1436 Automated Passport ... 163 ports of entry across the globe. Deployments ... combined CAGR of 37%. APC Kiosks reached 75% ...
(Date:2/2/2017)... Feb. 2, 2017  EyeLock LLC, a market leader ... white paper " What You Should Know About Biometrics ... ensuring user authenticity is a growing concern. In traditional ... users. However, traditional authentication schemes such as username/password suffer ... Biometric authentication offers an elegant solution to the problem ...
(Date:1/30/2017)... SAN FRANCISCO , Jan. 30, 2017   ... of the fastest growing genetic information companies, today announced ... 2016 financial results and provide 2017 guidance on Monday, ... a conference call that day at 4:45 p.m. Eastern ... call, Invitae,s management team will briefly review financial results, ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... ... February 23, 2017 , ... David ... Inventors Recognition Reception at Purdue Research Park of West Lafayette, Indiana. ... recognition of outstanding contributions to, and success with, commercializing discoveries from Purdue research. ...
(Date:2/23/2017)... , Feb. 23, 2017  Capricor Therapeutics, Inc. (NASDAQ: CAPR), ... medical conditions, today announced that Linda Marbán, Ph.D, president and ... investor conferences: Cowen and Company 37th ... am ET Boston, MA ... 9:00 am PT (12:00 pm ET) Dana Point, ...
(Date:2/23/2017)... BELLINGHAM, Washington, USA, and CARDIFF, UK (PRWEB) , ... ... ... SPIE, the international society for optics and photonics , have been named Fellows ... each individual’s significant scientific and technical contributions in the multidisciplinary fields of optics, ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... Park ... free AFM Luncheon for all SPIE attendees and Park customers ... just one block from the San Jose Convention Center. The luncheon will feature ...
Breaking Biology Technology: