Navigation Links
First genetic link to common migraine exposed
Date:8/29/2010

A world-wide collaboration of researchers has identified the first-ever genetic risk factor associated with common types of migraine. The researchers, who looked at the genetic data of more than 50,000 people, have produced new insights into the triggers for migraines attacks and they hope their research will open the door for novel therapeutics to prevent migraine attacks.

The team found that patients with a particular DNA variant on Chromosome 8 between two genes PGCP and MTDH/AEG-1 have a significantly greater risk for developing migraine. The team also discovered a potential explanation for this link. It appears that the associated DNA variant regulates levels of glutamate a chemical, known as a neurotransmitter, which transports messages between nerve cells in the brain. The results suggest that an accumulation of glutamate in nerve cell junctions (synapses) in the brain may play a key role in the initiation of migraine attacks. Prevention of the build up of glutamate at the synapse may provide a promising target for novel therapeutics to ease the burden of the disease.

Migraine affects approximately one in six women and one in twelve men, and has been estimated to be the most expensive brain disorder to society in the EU and US. A US report measures its economic costs as similar to those of diabetes and WHO lists it as one of the top 20 diseases with years lived with disability (YLDs).

Although researchers have in the past described genetic mutations giving rise to rare and extreme forms of migraine, this is the first time a team has identified a genetic variant giving rise to the common form of the condition.

"This is the first time we have been able to peer into the genomes of many thousands of people and find genetic clues to understand common migraine," said Dr Aarno Palotie, chair of the International Headache Genetics Consortium at the Wellcome Trust Sanger Institute, which spearheaded the study.

"Stu
'/>"/>

Contact: Don Powell
press.officer@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Healthy ears hear the first sound, ignoring the echoes
2. Genetic structure of first animal to show evolutionary response to climate change determined
3. Smithsonian scientists help create first frozen repository for Hawaiian coral
4. Creation of the first frozen repository for Hawaiian coral
5. Scientists find the first evidence of genetically modified plants in the wild
6. First satellite measurement of water volume in Amazon floodplain
7. Genome of ancient sponge reveals origins of first animals, cancer
8. First nearshore survey of Antarctic krill reveals high density, stable population in shallow waters
9. Discovered: Audubons first engraving of a bird
10. First step toward electronic DNA sequencing: Translocation through graphene nanopores
11. First-of-its-kind map details the height of the globes forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... as a world-famous vacation spot with natural tourism resources, a ... The Korea Institute of Geoscience and Mineral Resources (KIGAM) indicated ... volcanic eruption was evident 5,000 years ago. That is the ... spewed out of a volcano 5,000 years ago in the ... the whole peninsula. , The research team led by Dr. ...
(Date:7/22/2014)... type of immune cell widely believed to exacerbate ... and multiple sclerosis (MS), can actually protect the ... slow the progression of neurodegenerative diseases, according to ... journal Nature Communications . , The research ... the Department of Neurosciences at Cleveland Clinic,s Lerner ...
(Date:7/21/2014)... a professor of entomology and cooperating faculty ... the University of California, Riverside, has been awarded the ... of Chemical Ecology ( ISCE ). , Awarded first ... the society,s highest honor. It is awarded annually to ... the study of chemicals that mediate interactions between living ...
Breaking Biology News(10 mins):Jeju Island is a live volcano 2Cleveland Clinic researchers discover neuroprotective role of immune cell 2UC Riverside entomologist receives international honor for chemical ecology contributions 2
... chess. Then it was Jeopardy. Now computers are ... to automate the scientific process itself. An interdisciplinary ... CFD Research Corporation, Inc., has taken a major step ... analyze raw experimental data from a biological system and ...
... ) -- A University of California, Riverside assistant professor ... grant to study the impact of air-polluting black carbon ... The three-year grant from the Environmental Protection Agency will ... the Center for Environmental Research and Technology at UC ...
... Oct. 13, 2011 A team of researchers has shown ... to be overweight post-neutering when compared with entire littermates. This ... the fundamental science centre supporting Mars Petcare brands such as ... by WALTHAM scientists, neutered female kittens consumed more food than ...
Cached Biology News:Robot biologist solves complex problem from scratch 2Robot biologist solves complex problem from scratch 3Fighting pollution to slow climate change 2New research from WALTHAM demonstrates the importance of portion control for maintaining healthy body weight in neutered female kittens 2
(Date:7/22/2014)... (NASDAQ: NEOG ) announced today that revenues ... increased 19% from the previous year to $247,405,000. Fiscal ... year,s $27,190,000. Adjusted for a 3-for-2 stock split effective ... year were $0.76, compared to $0.75 a year ago. ... year established new all-time highs for the 32-year-old company. ...
(Date:7/22/2014)... SHENZHEN , Cina, 22 luglio 2014 /PRNewswire/ ... filiale di BGI, la maggiore organizzazione di genomica del ... servizio di sequenziamento dell,intero esoma umano con base la ... Complete Genomics, molto apprezzata nel settore per essere ... il 99.999% di precisione e una rilevazione altamente sensibile ...
(Date:7/22/2014)... SHENZHEN, China , July 22, 2014 /PRNewswire/ ... a subsidiary of BGI, the world,s largest genomics ... new human whole exome sequencing service based on ... includes in-depth bioinformatics analysis and SNP validation, and ... 2014. Complete Genomics, highly regarded ...
(Date:7/22/2014)... 22, 2014 In chemical and ... increasingly common sight. The rapid rise of TDL ... well- established as a core gas measurement technology, ... made them the gas analyzer technology of choice ... encountered in some processes have limited their application ...
Breaking Biology Technology:Neogen reports 19% increase in annual revenues 2Neogen reports 19% increase in annual revenues 3Neogen reports 19% increase in annual revenues 4Neogen reports 19% increase in annual revenues 5Neogen reports 19% increase in annual revenues 6Neogen reports 19% increase in annual revenues 7Neogen reports 19% increase in annual revenues 8BGI Tech lancia un servizio di sequenziamento dell'intero esoma umano sulla piattaforma avanzata di Complete Genomics 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3METTLER TOLEDO Shows How Tunable Diode Lasers (TDLs) Can Be Installed Where No TDLs Have Gone Before 2
... could include more elements than the "0" and "1" in ... kind of bit with single electrons, called quantum bits, or ... defined. So far, quantum bits have only existed in relatively ... semiconductors. They have put an effect in practice, which ...
... Calif., March 22, 2012 Based on its recent ... Frost & Sullivan recognizes iCubate with the 2012 North ... has developed the new version of a "gold standard" ... the ability to perform simple extraction, amplification, and detection, ...
... Panama held a ,Forum on Transgenic Mosquitoes, on Wednesday ... at this event have previously registered on repeated occasions ... ensuring that a balanced and productive discussion could not ... partnership with the Gorgas Institute in Panama to evaluate ...
Cached Biology Technology:How the alphabet of data processing is growing: Research team generates flying 'qubits' 2Frost & Sullivan Recognizes iCubate for Developing the New Gold Standard Instrument in the PCR Market 2Frost & Sullivan Recognizes iCubate for Developing the New Gold Standard Instrument in the PCR Market 3Frost & Sullivan Recognizes iCubate for Developing the New Gold Standard Instrument in the PCR Market 4Oxitec Responds to University of Panama's 'Forum on Transgenic Mosquitoes' 2
...
For mRNA Differential Display with three one-base anchored oligo-dT primers and rationally designed arbitrary 13mers. These kits feature the latest generation of isotopic mRNA Differential Display t...
NATIVE, ENZYME PORCINE TRYPSIN...
G-Protein Coupled Receptor Assay, For 500 assays. SPA. Category: Drug Screening & Cellular Assays, Assays ....
Biology Products: