Navigation Links
First-ever therapeutic offers hope for improving blood transfusions
Date:6/25/2013

Case Medical Center, and director, Harrington Discovery Institute, UH Case Medical Center.

"One important aspect of our study is the insight that knowledge of banked blood's SNO-Hb status may be used to judge the efficacy of a transfusion," Stamler said.

This information would allow physicians to discriminate between blood donations that may cause harm versus those that will have restorative effects following transfusion.

The research team hypothesized that the loss of NO compromises the ability to dilate blood vessels and thereby deliver oxygen to tissues, which is critical for survival. Red blood cells lacking NO instead would plug small blood vessels and cause heart attacks and kidney failure. In contrast, restoration of NO would ensure oxygen delivery.

The study, funded by the National Heart Lung and Blood Institute (NHLBI), found that mice, rats and sheep transfused with untreated banked blood had decreased oxygen levels in skeletal muscle and other tissuesexactly the opposite of what would have been predicted. By contrast, in animals transfused with renitrosylated (NO repleted) red blood cells, tissue oxygenation improved. In addition, researchers applied the same treatment to anemic animals and found improved blood flow, tissue oxygenation, and kidney function.

Stamler explained that these results demonstrate that restoration of blood NO levels may be useful in treating and preventing a wide variety of conditions, including heart attacks and strokes, and kidney damage following surgery. The findings also may offer new promise for patients with sickle disease, malaria and other blood disorders. In addition, the data suggest that Stamler's therapeutic is a simple way to reverse the potential toxicity of regular blood transfusions.

The Food and Drug Administration considers a transfusion successful if 75 percent of the banked red blood cells are circulating in the body of the recipient 24 hours after admi
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First-ever 3-D stress map of developing embryonic heart sheds light on why defects form
2. Professor publishes on first-ever imaging of cells growing on spherical surfaces
3. China poised to accept first-ever non-animal test method for cosmetics
4. First-ever release of endangered burying beetles in Missouri
5. Scientists complete first-ever emperor penguin count from space
6. Drug development venture links translational research, business to launch new therapeutics
7. Autism discovery paves way for early blood test and therapeutic options
8. Salk scientists find potential therapeutic target for Cushings disease
9. Novel therapeutic approaches to cure chronic HBV infection
10. Intranasal neuropeptide Y may offer therapeutic potential for post-traumatic stress disorder
11. BUSM study reveals therapeutic targets to alter inflammation, type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... China , July 31, 2015 The 10 ... will be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary ... one of the world,s most influential annual meetings in the ... and enjoyable scientific gatherings. ICG-10 focuses on ...
(Date:7/27/2015)... LOS ANGELES , July 27, 2015 /PRNewswire/ ... providing evidence- and experience-based clinical improvement solutions, today ... coordination solution is now available on Android smartphones ... at inpatient and post-care organizations can use ZynxCarebook ... the same patient,s condition, streamline care transitions to ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, ... expected revenues in 2015 that relate to sales of FPC1025 for ... approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO of ... in China and we are proud that ... for Axon , its first ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... Research (ICSSR) in association with the Deutsche For-schungsgemeinschaft ... de la Recherche (ANR), the UKEconomic and Social ... Research (NWO) have launched the first set of ... between researchers in India and the four European ...
... found that Earth,s land areas have become much more likely ... in the middle of the 20th century. The research was ... Academy of Sciences . The statistics show that the ... wave afflicting the U.S. Midwest this year, very likely are ...
... advances recently in drug delivery, electronics, energy and ... are those whose at least one dimension is ... the same time, there is a great possibility ... of use or disposal, which could lead to ...
Cached Biology News:First Indian-European research networking projects in the social sciences launched 2First Indian-European research networking projects in the social sciences launched 3First Indian-European research networking projects in the social sciences launched 4Research links extreme summer heat events to global warming 2Research links extreme summer heat events to global warming 3Understanding the biological and ecological implications of safe nanotechnology 2
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... offering competitive market analysis and premium industry insights on the global resorcinol industry. ... on a collective study of vivid market scenarios and analysis of primary and ...
(Date:7/30/2015)... 30, 2015   GenoSpace , a leading ... and analysis of genomic and other biomedical data, ... joined the company as Vice President of Sales ... "GenoSpace partners with its ... analyze and explore complex sets of genomic, phenotypic ...
(Date:7/30/2015)... 30, 2015   Aratana Therapeutics, Inc . ... focused on the licensing, development and commercialization of ... that its strategic partner VetStem Biopharma, Inc. has ... of AT-016, an adipose-derived allogeneic stem cell product ... osteoarthritis pain in dogs. The double-blinded, ...
(Date:7/30/2015)... Pa. , July 30, 2015  Discovery ... that it has received the second $1.0M tranche ... Innovation Research (SBIR) grant valued at up to ... company,s aerosolized KL4 surfactant as a potential medical ... injury.  Discovery Labs was awarded an initial $1.0 ...
Breaking Biology Technology:Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... ECM Solution Available to Healthcare Organizations through CSC,s ... ... Va., June 11 CSC (NYSE: CSC ) today,announced ... through the company,s FirstPortfolio offering.,FirstPoint streamlines a health organization,s document ...
... 10 BioSpecifics,Technologies Corp. (OTC BB BSTC.OB-News) today ... shares of its common stock priced at $15,per ... The shares,were purchased by certain private investors on ... company managed PIPE transaction at a premium over ...
... KV Pharmaceutical Company,(NYSE: KVa/KVb), a fully integrated ... markets technology-differentiated,branded products and generic/non-branded prescription pharmaceuticals,today ... litigation filed by a smaller,generic drug company, ... with PrimaCare ONE(R), a prenatal vitamin product ...
Cached Biology Technology:CSC Adds Content Management to Hosted Healthcare Offering 2KV Pharmaceutical Company Comments on Legal Development in Its Branded Pharmaceutical Business 2KV Pharmaceutical Company Comments on Legal Development in Its Branded Pharmaceutical Business 3