Navigation Links
First-ever therapeutic offers hope for improving blood transfusions
Date:6/25/2013

Researchers from Case Western Reserve University School of Medicine have developed an unprecedented approach to restore nitric oxide (NO) to donated blood, a breakthrough that could dramatically reduce harmful effects from transfusions.

Jonathan Stamler, MD, and colleagues from Case Western Reserve School of Medicine and from Duke University Medical Center describe their findings in the June 24 issue of PNAS: Proceedings of the National Academy of Sciences of the United States of America. Stamler and his colleagues report that restoring blood levels of NO in animals prior to transfusion improved their tissue blood flow, oxygen delivery, and kidney function.

Patients in the U.S. receive approximately 15 million blood transfusions a year. The procedure is often used to replace blood lost through trauma, but also can supplement shortages in a patient's own ability to produce blood due to cancer and other diseases. Increasingly, medical research publications associate transfusions with harmful consequences including heart attacks, renal failure, and death. A compelling explanation put forward in the literature is that the quantity of NO declines rapidly after donation because it has a short lifespan. Normally, NO dilates blood vessels and allows red blood cells to access tissue and deliver oxygen.

In the blood, NO exists in a bioactive form called S-nitrosohemoglobin (SNO-Hb). The unique process Stamler and team developed to restore SNO-Hb so-called renitrosylation therapy could have significant benefits for millions of patients.

"Inasmuch of the world's supply of banked blood is deficient in SNO-Hb, efforts to restore its levels may hold great therapeutic promise," said Stamler, director, Institute for Transformative Molecular Medicine and the Robert S. and Sylvia K. Reitman Family Foundation Distinguished Chair in Cardiovascular Innovation, Case Western Reserve School of Medicine and University Hospitals (UH) Case Medical Center, and director, Harrington Discovery Institute, UH Case Medical Center.

"One important aspect of our study is the insight that knowledge of banked blood's SNO-Hb status may be used to judge the efficacy of a transfusion," Stamler said.

This information would allow physicians to discriminate between blood donations that may cause harm versus those that will have restorative effects following transfusion.

The research team hypothesized that the loss of NO compromises the ability to dilate blood vessels and thereby deliver oxygen to tissues, which is critical for survival. Red blood cells lacking NO instead would plug small blood vessels and cause heart attacks and kidney failure. In contrast, restoration of NO would ensure oxygen delivery.

The study, funded by the National Heart Lung and Blood Institute (NHLBI), found that mice, rats and sheep transfused with untreated banked blood had decreased oxygen levels in skeletal muscle and other tissuesexactly the opposite of what would have been predicted. By contrast, in animals transfused with renitrosylated (NO repleted) red blood cells, tissue oxygenation improved. In addition, researchers applied the same treatment to anemic animals and found improved blood flow, tissue oxygenation, and kidney function.

Stamler explained that these results demonstrate that restoration of blood NO levels may be useful in treating and preventing a wide variety of conditions, including heart attacks and strokes, and kidney damage following surgery. The findings also may offer new promise for patients with sickle disease, malaria and other blood disorders. In addition, the data suggest that Stamler's therapeutic is a simple way to reverse the potential toxicity of regular blood transfusions.

The Food and Drug Administration considers a transfusion successful if 75 percent of the banked red blood cells are circulating in the body of the recipient 24 hours after administration.

"Based on our findings, the criteria might need to be revised to include measures of red blood cell functionnamely the ability of banked blood to deliver oxygen," Stamler added.

Motivated by these promising findings, Stamler has secured a grant from the NHLBI of the National Institutes of Health (NIH) to begin a clinical trial to evaluate the oxygen delivery function of banked blood. In addition, the team has applied for NHLBI funding of a Phase I clinical trial to study the use of renitrosylation in patient transfusions. If funded, the trial would be based at University Hospitals Case Medical Center and would enroll approximately 30 healthy volunteers.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. First-ever 3-D stress map of developing embryonic heart sheds light on why defects form
2. Professor publishes on first-ever imaging of cells growing on spherical surfaces
3. China poised to accept first-ever non-animal test method for cosmetics
4. First-ever release of endangered burying beetles in Missouri
5. Scientists complete first-ever emperor penguin count from space
6. Drug development venture links translational research, business to launch new therapeutics
7. Autism discovery paves way for early blood test and therapeutic options
8. Salk scientists find potential therapeutic target for Cushings disease
9. Novel therapeutic approaches to cure chronic HBV infection
10. Intranasal neuropeptide Y may offer therapeutic potential for post-traumatic stress disorder
11. BUSM study reveals therapeutic targets to alter inflammation, type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring announced that after ... secured the final acceptance by all three (3) ... Systems (MAS) installed. Furthermore, Securus will have contracts ... by October, 2016. MAS distinguishes between legitimate wireless ...
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... 23, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... Laboratory, has joined STACS DNA as a Field Application Specialist. , “I am ... and COO of STACS DNA. “In further expanding our capacity as a scientific integrator, ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity ... intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining centers at ... result of a collaboration among several companies with expertise in toolholding, cutting tools, ...
Breaking Biology Technology: