Navigation Links
First-ever covalent irreversible inhibition of a protease central to hepatitis C infection
Date:11/28/2010

WALTHAM, MA November 28, 2010 Avila Therapeutics, Inc., a biotechnology company developing novel targeted covalent drugs, has published research in Nature Chemical Biology demonstrating the first-ever selective irreversible inhibition of a viral protease using a targeted covalent drug. In the paper titled "Selective Irreversible Inhibition of a Protease by Targeting a Non-Catalytic Cysteine", Avila used its proprietary Avilomics platform to design covalent irreversible protease inhibitors that are highly selective, potent and with superior duration of action as compared to conventional protease inhibitors.

Importantly, the published research demonstrates that covalent drugs can be designed and targeted to irreversibly and covalently bond to molecular domains specific to proteases. This is the first report of the irreversible covalent approach being successfully extended to proteases, a very broad class of proteins that includes many important potential drug targets.

"This research elevates covalent drug design to a fundamentally new level," said Simon Campbell, PhD, CBE, FMedSci, FRS, a renowned scientist and former Senior Vice President for Worldwide Drug Discovery and Medicinal R&D Europe of Pfizer. "By creating extremely selective protease inhibitors with their platform, Avila is showing the remarkable therapeutic potential of irreversible covalent drugs to address a broad spectrum of drug targets."

"This publication showcases the creation of a whole new class of small molecule drugs," said Juswinder Singh, PhD, Chief Scientific Officer of Avila and a co-author of the paper. "This approach can make a difference to patients living with HCV infection, and we expect to make an impact in other important areas such as cancer and inflammatory disease."

In order to maximize selectivity and minimize off-target effects, the irreversible covalent inhibitors of HCV protease were designed to covalently target a unique
'/>"/>

Contact: Kathryn Morris
kathryn@theyatesnetwork.com
914-204-6412
Yates Public Relations
Source:Eurekalert

Page: 1 2

Related biology news :

1. First-ever blueprint of a minimal cell is more complex than expected
2. UBC researchers find first-ever wanderlust gene in tiny bony fish
3. Afghanistan releases its first-ever list of protected species
4. UBC researcher gives first-ever estimate of worldwide fish biomass and impact on climate change
5. First-ever socioeconomic study on coral reefs points to challenges of coastal resource management
6. New clues to how cancer-related proteins plasmin, thrombin lose inhibition
7. Gene signal GS-101 data shows safe and effective inhibition of ophthalmic blood vessel growth
8. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
9. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
10. New regional facility opened to advance stable isotope research in central Appalachians
11. Barrow scientists uncover clues on inflammation in central nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... adipocytes, or fat cells, are inherently different. Each of ... its own role in metabolism. In the human body, ... Its primary function is energy storage. On the other ... but are only found in a few places in ... special type of brown adipocytes, appear mixed with brown ...
(Date:7/31/2014)... studies have shown that marine noise can affect animal ... the Universities of Bristol and Exeter and the cole ... demonstrated that boat noise stops embryonic development and increases ... the sea slug Stylocheilus striatus used in ... away and later feed on toxic alga but this ...
(Date:7/30/2014)... epigenetic processes to regulate its genes, and adapt to ... of the genome regulation taking place in the truffle, ... Biology and illustrates how the truffle deals with ... authors say this may shed light on how traits ... (Tuber melanosporum), also known as Prigord truffles, have a ...
Breaking Biology News(10 mins):Hope for the overweight 2Boat noise impacts development and survival of sea hares 2How black truffles deal with the jumpers in their genome 2
... Fast development is often perceived as an advantage, ... readiness to cope with the challenges that it poses. ... and University of California, Santa Cruz, and published in ... the acceleration of developmental rate incurs potentially lethal physiological ...
... molding some snow into a ball and hurling it or ... can? New research from Indiana University and the University of ... readily learn to throw long distances. This research also suggests ... in a way critical to our very existence. ...
... N.C. Despite what you might have heard, genetic sequencing ... Duke University Medical Center have shown that functional tests are ... of sequencing studies as they relate to disease, using a ... patients to have many different traits. "Right now ...
Cached Biology News:Faster development might have its costs 2Faster development might have its costs 3IU study: Humans' critical ability to throw long distances aided by an illusion 2IU study: Humans' critical ability to throw long distances aided by an illusion 3Genetic sequencing alone doesn't offer a true picture of human disease 2Genetic sequencing alone doesn't offer a true picture of human disease 3
(Date:7/31/2014)... BLOOMINGTON, Ind. -- Chemists at Indiana University Bloomington ... in bricks-and-mortar fashion, a development with potential value ... as field-effect transistors and photovoltaic cells. , Their ... 3D Crystalline Solids and 2D Self-Assembled Crystals," has ... a journal of the Royal Society of Chemistry. ...
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® bearings ... are uniquely suited to prevent loss of lubrication that ... high temperatures . , Recently, a manufacturer of ... at Graphite Metallizing to overcome problems with movement of ... pans containing blocks of powder mixture are loaded onto ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 CollabRx, Inc. ... inform therapeutic decision-making in oncology, today announced that it ... 2014 to discuss the Company's financial results for the ... update about the business in the current fiscal year. ... beginning on Thursday, August 14, 2014, at 5 p.m. ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
Breaking Biology Technology:Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
... deCODE genetics,(Nasdaq: DCGN ) today announced its ... 2008. A conference call to discuss the,quarter,s results, ... webcast live tomorrow, Friday, November 7, at 8:00am ... third quarter 2008 was $11.3 million, compared,to $22.2 ...
... NGX-4010 for management of pain associated ... with PHN, ... review for NGX-4010 ... NGSX ), a biopharmaceutical company focused on developing and,commercializing novel pain management ...
... While Public Relations has,long been used as a ... ability to reach consumers has never been greater. ... the traditional press,release as effective and low-cost methods ... was conducted by Best Practices, LLC to,identify what ...
Cached Biology Technology:deCODE genetics Announces Third Quarter 2008 Financial Results 2deCODE genetics Announces Third Quarter 2008 Financial Results 3deCODE genetics Announces Third Quarter 2008 Financial Results 4deCODE genetics Announces Third Quarter 2008 Financial Results 5deCODE genetics Announces Third Quarter 2008 Financial Results 6deCODE genetics Announces Third Quarter 2008 Financial Results 7deCODE genetics Announces Third Quarter 2008 Financial Results 8deCODE genetics Announces Third Quarter 2008 Financial Results 9deCODE genetics Announces Third Quarter 2008 Financial Results 10deCODE genetics Announces Third Quarter 2008 Financial Results 11deCODE genetics Announces Third Quarter 2008 Financial Results 12NeurogesX Reports Third Quarter 2008 Results 2NeurogesX Reports Third Quarter 2008 Results 3NeurogesX Reports Third Quarter 2008 Results 4NeurogesX Reports Third Quarter 2008 Results 5NeurogesX Reports Third Quarter 2008 Results 6NeurogesX Reports Third Quarter 2008 Results 7NeurogesX Reports Third Quarter 2008 Results 8NeurogesX Reports Third Quarter 2008 Results 9New Study Shares Best Practices in Biopharma Public Relations 2
Angiotensin Converting Enzyme [Porcine Kidney, ACE, Peptidyl-dipeptidase A]...
Oven mesh sheets, large, 23 x 23cm, pack of 5...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... Analysis Note: Protein determined by Biuret ... 25 mM Tris-HCl, pH 7.6, 1 mM ... 2 Preparation Unit Definition: One unit ... per minute at pH 9.8 at 37 ...
Biology Products: