Navigation Links
First-ever 3-D stress map of developing embryonic heart sheds light on why defects form
Date:10/31/2012

WASHINGTON, Oct. 31As a human fetus develops, its heart has to keep pace with the new body's ever-growing demands. Much of this is controlled by following genetic blueprints, but the embryonic heart also matures in response to the intense stresses of pumping blood. For the first time, researchers have been able to visualize in 3-D the stresses induced by flowing blood in an embryonic heart. The technique, which promises to provide new insight into how and why heart defects develop, is described in a paper published today in the Optical Society's (OSA) open-access journal Biomedical Optics Express.

The researchers, led by Andrew M. Rollins, an associate professor of biomedical engineering at Case Western Reserve University in Cleveland, looked at a particular type of stress in the heart known as shear stress, which is simply the parallel force of one material sliding along another. In the developing heart, shear stress is induced in the heart's own endocardial cells as blood cells rush past them. Normally, such shear stress helps to control and regulate cellular processes involved in heart development. Even tiny aberrations in the heart beat, however, can alter blood flow patterns and change these developmental forces, leading to congenital heart defects such as abnormal valve formation.

"All previous attempts at shear-stress mapping have been two dimensional, but the 3-D geometry of the embryonic heart is changing hour by hour at these early stages, and the shape of the heart twists and turns as it develops," says Rollins, "so a 2-D projection doesn't really provide a good approximation."

Rollins and his colleagues at Case Western Reserve developed their new imaging method by modifying a technique called Doppler optical coherence tomography, or OCT. In OCT, a beam of infrared light is shined on a tissue and the "echoes" (or reflections) of that light produced at varying depths are used to make an image. "It is just like RADAR
'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Professor publishes on first-ever imaging of cells growing on spherical surfaces
2. China poised to accept first-ever non-animal test method for cosmetics
3. First-ever release of endangered burying beetles in Missouri
4. Scientists complete first-ever emperor penguin count from space
5. Oxidative stress and altered gene expression occurs in a metabolic liver disease model
6. Wake Forest Baptist Offers Tips on How to Avoid and Relieve Campaign Season Stress
7. Oyster genome uncover the stress adaptation and complexity of shell formation
8. Relieving plant stress could eventually help humans relax
9. UMD study shows exercise may protect against future emotional stress
10. Low ghrelin -- reducing appetite at the cost of increased stress?
11. Stress hormones: Good or bad for posttraumatic stress disorder risk?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First-ever 3-D stress map of developing embryonic heart sheds light on why defects form
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... addition of the "The Global Watermarking and ... http://photos.prnewswire.com/prnh/20130307/600769 ... digital media watermarking and fingerprinting markets. Watermarking aims ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and Markets ... of the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... 2012, Apple introduced the fingerprint reading feature with the ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... , , , TORONTO, Dec. 7 ... the assets of the healthcare communications company previously operating as ... move forward under new leadership and funding. , IgeaCare Solutions ... Chief Executive Officer. Under his direction, the new company will ...
... , , , , , LONDON, ... spending more on protecting their borders, which are increasingly ... investment in advanced technology security and IT-based systems will ... ) , New analysis from Frost & Sullivan ( ...
... Springer has just signed an agreement with the British Society ... with the journal Biogerontology for an initial period ... of the Biogerontology editorial board and will acquire ... the society and provide society members with free electronic access ...
Cached Biology News:IgeaCare Solutions Inc. Emerges Under New Leadership and Funding 2Increased Spending on the EU's External Borders to Drive the Border Security Market, Says Frost & Sullivan 2Increased Spending on the EU's External Borders to Drive the Border Security Market, Says Frost & Sullivan 3
(Date:1/22/2015)... 2015 Eckert & Ziegler Vitalea Science ... services to the pharmaceutical and biotech industry, has announced ... in the position of Director of Science & Technology. ... valuable experience in drug metabolism and bioanalysis to EZVS ...
(Date:1/22/2015)... GEA Niro Soavi the leader in ... the PandaPLUS 2000, which is ideal for new applications ... cell disruption . This compact laboratory homogenizer is the ... food, food additives and ingredients as well as for ...
(Date:1/22/2015)... 22, 2015 The laboratory information management ... witnessed a number of technological advancements due to factors ... growing need to integrate healthcare systems, and increasing government ... in system integration. Key players in the market focus ...
(Date:1/22/2015)... Pipette.com has added the Eppendorf ... portfolio of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 ... 5424/5424 R and receive the following:, , ... or Eppendorf Reference 2 ,     3 Free ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... , PLEASANTON, Calif., FRAMINGHAM, Mass. and ... ), a world leader in device-based mechanical circulatory support therapies ... Inc. (Nasdaq: HTWR ; ASX: HIN), which develops ... United States Federal Trade Commission ("FTC") has informed them that ...
... SADDLE RIVER, N.J., July 29 PDI, Inc. (Nasdaq: ... support to U.S. pharmaceutical companies, today announced that it will release ... after the market close. , , PDI ... Eastern time on August 5, 2009 to discuss the results. To ...
... Calif., July 29 InterMune, Inc. (Nasdaq: ITMN ) ... on Thursday, August 6, 2009 at 4:00 p.m. Eastern time. ... at 4:30 p.m. Eastern time that same day. , , ... 973-200-3372 (international), conference ID# 22196018. To access the webcast, please ...
Cached Biology Technology:U.S. Federal Trade Commission to Challenge Thoratec's Proposed Acquisition of HeartWare International 2U.S. Federal Trade Commission to Challenge Thoratec's Proposed Acquisition of HeartWare International 3U.S. Federal Trade Commission to Challenge Thoratec's Proposed Acquisition of HeartWare International 4PDI, Inc. to Hold Second Quarter 2009 Financial Results Conference Call on Wednesday, August 5, 2009 2InterMune to Release Second Quarter Financial Results on August 6 2
Agarose II (Low Melt)...
...
... Buffer I can be used in intracellular ... permeabilize cells and to serve as an ... saponin-mediated cell permeabilization is a reversible process, ... in the presence of saponin during intracellular ...
... antibody raised against a partial ... Immunogen: PPP4C (NP_002711, 218 ... recombinant protein with GST tag. ... NM_002720 ...
Biology Products: