Navigation Links
First drug candidate from NIH program acquired by biopharmaceutical company
Date:7/9/2014

ructural change may lessen sickling-related complications in patients.

Sickle cell disease disproportionately affects African-Americans and is considered both rare and neglected in the United States. African-Americans with sickle cell often face significant health disparities in clinical care. Life expectancy for people with sickle cell disease is only to mid- to late 40s.

Prior to AesRx's collaboration with TRND researchers, and despite promising data on Aes-103, the company had difficulty securing private financing because potential investors lacked interest in funding an early-stage project that was considered too risky. AesRx did not have the resources to complete preclinical and early clinical development.

Currently, the only drug approved by the U.S. Food and Drug Administration (FDA) to treat sickle cell disease is hydroxyurea, a drug initially developed to treat cancer. However, the clinical utility of hydroxyurea is limited. Many individuals with sickle cell disease either do not respond to the drug, or they may experience undesirable side effects.

"Sickle cell was the first disease to ever have its molecular cause discovered more than 65 years ago and now a potential treatment based on that discovery has at last been developed," said NCATS Director Christopher P. Austin, M.D. "This success validates the NCATS model, which is based on a novel collaborative approach that de-risks intervention development programs to enable private-sector investment. We look forward to applying this model to the thousands of rare diseases that are currently untreatable so that we realize the NCATS mission of getting more treatments to more patients more quickly."

TRND researchers signed a collaborative agreement with AesRx in 2010 and established a project team made up of NCATS and AesRx scientists as well as a leading sickle cell disease clinical researcher at the National Heart, Lung, and Blood Institute (NHLBI). Other key p
'/>"/>

Contact: NCATS Office of Communications
spencerg@mail.nih.gov
301-435-0888
NIH/National Center for Advancing Translational Sciences (NCATS)
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Kessler Foundation implements Ekso Bionics first commercial robotic exoskeleton
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. First model of how buds grow into leaves
4. American College of Rheumatology releases first classification criteria for polymyalagia rheumatica
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. First complete full genetic map of promising energy crop
7. FirstMark Announces New Hire Jay Houtman as Southeast Regional Sales Manager
8. FirstMark Exhibiting at the Inaugural Atlanta Clinical Cardiology Update
9. New technology tracks sparrow migration for first time from California to Alaska
10. First mass extinction linked to marine anoxia
11. Scientists complete first-ever emperor penguin count from space
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First drug candidate from NIH program acquired by biopharmaceutical company
(Date:6/24/2015)... JOSE, Calif. , June 24, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... sensor to provide secure authentication for its latest ... recently reached more than 200 million shipments of ... with Sharp reinforces Synaptics, strength, scalability and leadership ...
(Date:6/23/2015)... RALEIGH, N.C. , June 23, 2015 /PRNewswire/ ... technology, today announced the results of a recent ... unmatched accuracy on the wrist during activity. In ... biometric technology was compared along with the Apple ... for accurately measuring heart rate during activity. The ...
(Date:6/17/2015)... , and HILDEN, Germany , June 17, ... ; Frankfurt Prime Standard: QIA) today launched new Investigator ® ... forensic laboratories in the United States . ... simultaneously analyze multiple key genomic markers (short tandem repeats or ... Quality Sensor to evaluate the quality of DNA in each ...
Breaking Biology News(10 mins):Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... NASA,s space shuttle Discovery will make its swan song ... Boulder-built biomedical payload devices, including one to help scientists ... in the low gravity of space as a way ... The experiments will be carried aboard Discovery in sets ...
... Washington, DC (October 27, 2010) Recognizing the ... Collegiate Inventors Competition, a program of Invent Now, today ... in mice to facilitate drug testing and a way ... in this year,s competition. Alice Chen of the ...
... Move over, touchpad screens: New research funded in part ... possible to manipulate complex visual images on a computer screen ... Nature , found that when research subjects had their brains ... force the computer to display one of the images and ...
Cached Biology News:Swan song of space shuttle Discovery to carry 2 payloads built by CU-Boulder 2Swan song of space shuttle Discovery to carry 2 payloads built by CU-Boulder 3Winners announced in 2010 Collegiate Inventors Competition 2Winners announced in 2010 Collegiate Inventors Competition 3Winners announced in 2010 Collegiate Inventors Competition 4Winners announced in 2010 Collegiate Inventors Competition 5From touchpad to thought-pad? 2From touchpad to thought-pad? 3
(Date:7/7/2015)... ... July 07, 2015 , ... CSM, a leading clinical trial supply company, today ... Morse has an extensive background in financial management and accounting, bringing over 20 years ... new role, Morse will oversee all financial areas of the company to both strengthen ...
(Date:7/6/2015)... USA, and CARDIFF, UK (PRWEB) , ... July ... ... in ophthalmology and other medical fields holds potential to reveal how blood flows ... and reduce stroke-induced damage to the brain. , A new article published in ...
(Date:7/6/2015)...  Approximately 1% of the population inherits a common ... individuals are three times more likely to develop angina, ... the nation,s leading medical journals by researchers from the ... Photo - http://photos.prnewswire.com/prnh/20150706/230685 The ... (also known as "sixth disease") and occasional seizures in ...
(Date:7/6/2015)... , June 29, 2015 ... has announced the addition of the "Biotechnology ... Biotechnology for the Non-Biotechnologist, ideal for ... theory, principles, techniques and potential of biotechnology. ... understand the basic theory, principles, techniques, and potential ...
Breaking Biology Technology:CSM Appoints Michael Morse as Vice President of Finance 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3
... (Nasdaq: EXEL ) announced today that George A. ... present at,the 19th Annual Piper Jaffray Health Care Conference ... November 27, 2007., The presentation will be webcast ... Investors on the Exelixis website at, http://www.exelixis.com ., ...
... findings published in November 22 issue of Nature ... first system-wide gene-analysis of microbial community focused ... Nov. 21 Verenium,Corporation (Nasdaq: VRNM ), ... and a pioneer in the development of,high-performance specialty ...
... SGX Pharmaceuticals, Inc.,(Nasdaq: SGXP ) announced today that ... which Mike Grey, president & chief,executive officer of SGX Pharmaceuticals, ... information is as follows:, -- 19th Annual Piper ... November 27, 2007 at 11:30 AM Eastern Standard Time at ...
Cached Biology Technology:Verenium Explores Bacterial Genes Inside Termite Guts to Understand How Wood is Broken Down and Converted to Energy 2Verenium Explores Bacterial Genes Inside Termite Guts to Understand How Wood is Broken Down and Converted to Energy 3Verenium Explores Bacterial Genes Inside Termite Guts to Understand How Wood is Broken Down and Converted to Energy 4Verenium Explores Bacterial Genes Inside Termite Guts to Understand How Wood is Broken Down and Converted to Energy 5SGX Pharmaceuticals to Present at Two Upcoming Investor Conferences 2
... Antibody, Unconjugated Applications: ... dilution of 1/100. IP: Use at ... at an assay dependent dilution. Predicted ... in other applications. Optimal dilutions/concentrations ...
Kit containing MACS equipment and reagents for immunopurification of proteins....
Membrane Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
... Successful biomarker discovery projects require ... samples to distinguish clinically relevant data ... CiphergenExpress Data Manager is now available ... sample tracking and data flood inherent ...
Biology Products: