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First description of a triple DNA helix in a vacuum
Date:4/18/2012

these DNA structures to be detected more easily", affirms Dr. Orozco.

Shedding light on biological molecules

Furthermore, these results pave the way for the implementation of new structural resolution techniques based on the use of x-ray free-electron lasers (X-FEL). The X-FEL is a large scientific facility being built in Germany that produces intense light pulses, similar to a synchrotron. "If our calculations are correct X-FEL could be used to obtain structural data in gas phase about the behavior of a molecule in its natural biological environment and X-FEL would become a very powerful tool to resolve the structure of macromolecules", Orozco goes on to say.

Computational simulation has been performed using the supercomputer MareNostrum at the BSC while the experimental validation has been undertaken by the Mass Spectrometry Core Facility at IRB Barcelona, the Experimental Bioinformatics Lab (EBL) a joint IRB Barcelona and BSC facility-, and with the collaboration of Valerie Gabelica's group at the University of Lige, Belgium.


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Contact: Sonia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

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