Navigation Links
First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved
Date:9/30/2014

Engineers at the University of California, San Diego, have completed the first comprehensive numerical simulation of skeletal muscle tissue using a method that uses the pixels in an image as data points for the computer simulationa method known as mesh-free simulation.

The researchers, led by J.S. Chen, the William Prager Professor of structural engineering at the Jacobs School of Engineering at UC San Diego, presented their findings on the development of this method at the CompIMAGE'14 conference in Pittsburgh this month. Chen also gave a keynote speech about the work.

Chen's group has now expanded the use of mesh-free simulation methods to investigate aging and disorders impacting muscle functions, such as muscular dystrophy. "Another area of application for this framework would be the simulation of tissue injuries caused by extreme events such as blasts, car crashes and sport collisions". Chen said. This will require adding the mechanics of tissue damage to the simulation model, including how tissue behaves and functions under high velocity impact.

Traditionally, engineers rely on the reconstruction of the geometry captured by from CT scans or MRI images to create simulation models of biological materials, such as muscle tissue. The reconstructed 3D geometry is then used to generate a mesh to describe the material's structurethis is known as the conventional finite element method. This procedure is extremely time consuming and labor intensive.

Using the mesh-free method cuts back on the amount of time for the process of generating the simulation model because researchers don't have to build a mesh for the structure they're trying to simulate, said Ramya Rao Basava, the lead Ph.D. student on the study.

For this study, researchers in Chen's group used Magnetic Resonance and Diffusion Tensor images for the mesh-free simulation. The images were obtained through the Department of Radiology at UC San Diego. The image data acquired was from 10 volunteers between the ages of 20 to 90. The younger subjects were mostly in their 20s and 30s, the older ones mostly in their 80s.

Chen's research group used the simulation techniques they developed to look at how much force is generated from various muscle systems, and more specifically at how loss of force relates to loss of muscle volume due to aging. They found that the loss of force is greater than the loss of volume, which is consistent with prior physiological studies.

Chen is a leader in the field of computational mechanics, particularly mesh-free methods for structures and materials subjected to large deformation and damages.

Chen's research group has advanced mesh-free method research to achieve high accuracy and efficiency in simulating a wide range of engineering and scientific problems that are difficult or impossible to simulate via mesh-based methods, for example, fragment-impact modeling for homeland security applications, landslide simulations in natural disaster predictions, manufacturing processes and contact-impact modeling in the automotive industry, multi-scale materials modeling in material science applications and modeling of DNA-protein interaction, among others. Recently, his research group has started venturing into the field of simulation for biological materials such as muscle tissue.

Chen is also the faculty director of UC San Diego's new Center for Extreme Events Research, which has been established to offer solutions to a wide range of challenges associated with extreme events, such as blasts and landslides, and brings together unique experimental technologies and advances in computational methods.


'/>"/>

Contact: Ioana Patringenaru
ipatrin@ucsd.edu
858-822-0899
University of California - San Diego
@UCSanDiego
Source:Eurekalert  

Related biology news :

1. A wriggly solution to a first-world problem
2. March of Dimes honors Arizona with first-ever newborn screening award
3. NAMS issues first comprehensive recommendations on care of women at menopause and beyond
4. Vitamin E intake critical during the first 1,000 days
5. Scientists report first semiaquatic dinosaur, Spinosaurus
6. UT Southwestern expert co-chairs national team to develop first comprehensive guidelines for management of sickle cell disease
7. Behçets syndrome drugs to be investigated for first time
8. California blue whales rebound from whaling, first of their kin to do so
9. ASHG and NHGRI award first genetics and education fellowship
10. Kessler Foundation researchers publish first study of brain activation in MS using fNIRS
11. runScribe Fitness Wearable Exceeds 200% of Kickstarter Goal in First Week
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved
(Date:5/31/2019)... VIEJO, Calif. (PRWEB) , ... May 30, 2019 ... ... leading clinical genetics testing company, and Mayo Clinic, have documented significant differences in ... cancer among racial and ethnic populations compared to non-Hispanic White women. Results will ...
(Date:5/24/2019)... ... May 24, 2019 , ... The newest edition of Crystallography ... on the company’s global website. , Crystallography Times is a monthly electronic newsletter published ... serves the X-ray analysis community by presenting the latest news and crystallographic research. ...
(Date:5/21/2019)... ... May 21, 2019 , ... If a genetically ... How can we tell it apart from the millions of microorganisms that exist ... research team, including Eric Young , assistant professor of chemical engineering at ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... Pa. (PRWEB) , ... May 15, 2019 , ... Milton ... Year in recognition for his work within the biomedical industry, where he is changing ... improved medical devices. , “William Harding epitomizes the vision of our founders – ...
(Date:5/8/2019)... ... 2019 , ... Standing at 16.2 hands, Atlas is on the large side for a Quarter ... barrel racing, among other activities. When loping around a corner in late 2017, Atlas ... busy horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the ...
(Date:5/2/2019)... ... April 30, 2019 , ... By ... USA Inc. has demonstrated its ability to provide various services and products ... enhance customer satisfaction through the effective implementation of its quality management system, ...
(Date:5/2/2019)... ... 02, 2019 , ... Boston Robotic Hair Restoration announces the ... the days of painful hair transplant procedures. Boston Robotic Hair Restoration offers the ... robotic intelligent solution to offer a minimally invasive procedure. With the ARTAS® iX ...
Breaking Biology Technology: