Navigation Links
First comprehensive library of master genetic switches in plants
Date:7/17/2014

, explained that the collection will "ultimately, help us understand at the molecular level the mechanisms of how plants work." Pruneda-Paz helped create the library as a postdoctoral researcher, first in Kay's laboratory at The Scripps Research Institute in La Jolla, California, then at the University of California, San Diego, where he is now a faculty member.

Kay elaborated: "Along the way we are going to understand the wiring the instruction manual for how plants grow and develop. From that knowledge base comes all the translational opportunities."

The clones in the library were taken from Arabidopsis, a flowering plant related to cabbage and mustard.

"You can think of Arabidopsis as the mouse of the botanical world," Kay said. "In the same way we learn a great deal about human biology from flies and mice, we learn a huge amount about clock biology because Arabidopsis is a great plant to grow in the lab."

Pruneda-Paz and Ghislain Breton, another former postdoctoral researcher in Kay's lab and co-first author of the study, recount what first led to the idea of creating a library in 2006.

The scientists were attempting to understand how plants adapt to cycles of light and dark, and zeroed in on the production of CCA1 and LHY, transcription factors that regulate Arabidopsis clock genes. Traditionally, researchers decipher the function of a gene by mutating the gene and seeing whether those mutations are responsible for a certain phenotype.

But when this method didn't work, the researchers decided to "use this reverse genetics approach," Pruneda-Paz explained. "Rather than trying to do a mutation to find a gene, we could clone all the transcription factors and then figure out which transcription factors bind and regulate the expression of CCA1. For this, we started this collection."

Breton and Pruneda-Paz oversaw the initial construction of the library. In 2010 when Breton l
'/>"/>

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A first direct glimpse of photosynthesis in action
2. First drug candidate from NIH program acquired by biopharmaceutical company
3. Rockefeller scientists first to reconstitute the DNA replication fork
4. Archaeopteryx plumage: First show off, then take-off
5. A first: Scientists show bacteria can evolve a biological timer to survive antibiotics
6. First positive results toward a therapeutic vaccine against brain cancer
7. Drug shows promise for the first time against metastatic melanoma of the eye
8. Super bananas -- world first human trial
9. Findings point toward one of first therapies for Lou Gehrigs disease
10. Alcohol abuse damage in neurones at a molecular scale identified for first time
11. Spectrum Health among first to implant neurostimulator for epilepsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... , Finnland, October 1, 2014 /PRNewswire/ ... Durchbruch im Bereich der Biowissenschaften   ... ein Kommen und Gehen zahlreicher Detektionstechnologien. Einige ... zum goldenen Standard. Die Photonen-Upconversion ist eine ... letzten Jahren mit Begeisterung aufgenommen wurde. Jetzt ...
(Date:9/30/2014)... San Diego, have completed the first comprehensive numerical simulation ... the pixels in an image as data points for ... The researchers, led by J.S. Chen, the William Prager ... Engineering at UC San Diego, presented their findings on ... in Pittsburgh this month. Chen also gave a keynote ...
(Date:9/30/2014)... Calif. The National Institutes of Health (NIH) ... today to develop an electrode array system that ... brain works through unprecedented resolution and scale. , ... to support President Obama,s BRAIN (Brain Research ... research effort to revolutionize our understanding of the ...
Breaking Biology News(10 mins):Innovative Verwendungslösung für die Photonen-Upconversion 2Innovative Verwendungslösung für die Photonen-Upconversion 3First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3
... living in densely populated urban areas have a profound impact ... health and fitness of native wildlife. For the first time, ... urbanization and the prevalence and severity of two distinct parasites ... today,s issue of the journal PLOS ONE . ...
... made the world,s temperature records available via Google Earth. ... temperature dataset is one of the most widely used records ... allows users to scroll around the world, zoom in on ... data more easily than ever before. Users can drill ...
... Biological Studies will join Stanford University in leading a ... through a $40 million award by California,s stem cell ... center will bring together experts and investigators from seven ... of genomics the study of the complete genetic ...
Cached Biology News:Presence of humans and urban landscapes increase illness in songbirds, researchers find 2Presence of humans and urban landscapes increase illness in songbirds, researchers find 3World temperature records available via Google Earth 2Salk Institute and Stanford University to lead new $40 million stem cell genomics center 2Salk Institute and Stanford University to lead new $40 million stem cell genomics center 3
(Date:10/1/2014)... 2014 TeselaGen Biotechnology has ... to expand their bioCAD/CAM software suite, which uses ... The Small Business Innovation Research Phase II grant will ... exclusive license from the Lawrence Berkeley National Laboratory. j5 ... an LBNL laboratory that develops alternative fuel technologies for ...
(Date:10/1/2014)... This report analyzes the worldwide ... by the following Product Segments: Proteases, Polymerases, ... segments also analyzed are Pharmaceuticals & Diagnostics, ... provides separate comprehensive analytics for the US, ... Latin America. Annual estimates and forecasts are ...
(Date:9/30/2014)... German . , The ... a semiconductor layer. Quantum dots are small structures that spontaneously ... short laser pulse is fired at the photonic crystal, its ... change in the electromagnetic field around it. This change can ... the dot. As soon as the refractive index recovers its ...
(Date:9/30/2014)... German . , ... demonstrated a new kind of building block for digital ... could be based on three-dimensional arrangements of nanometer-scale magnets ... the semiconductor industry CMOS fabrication of silicon chips ... at the University of Notre Dame are exploring "magnetic ...
Breaking Biology Technology:TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Ultrafast remote switching of light emission 2A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3
... Pa., Oct. 5 Genaera,Corporation (Nasdaq: GENR ... at two upcoming conferences, Biotech 2007 in Philadelphia ... San Francisco on October,9-11, 2007. Henry R. ... of Genaera, is scheduled to participate in a ...
... BASINGSTOKE, England and CAMBRIDGE, Massachusetts, October 4, Shire ... that Japan,s Ministry of Health, Labour and Welfare ... the treatment of,Hunter syndrome, for sale and marketing ... ELAPRASE is now approved for marketing and commercial,distribution ...
... Pharmasset, Inc.,(Nasdaq: VRUS ) has entered into a ... to certain terms and conditions of,the agreement, Horizon will ... its option, Pharmasset may receive a second loan of ... of $10 million by November 30, 2008,provided conditions precedent ...
Cached Biology Technology:Genaera to Present at Biotech 2007 and BIO InvestorForum 2Genaera to Present at Biotech 2007 and BIO InvestorForum 3Shire's ELAPRASE(R) (idursulfase) Approved in Japan for the Treatment of Hunter Syndrome 2Shire's ELAPRASE(R) (idursulfase) Approved in Japan for the Treatment of Hunter Syndrome 3Shire's ELAPRASE(R) (idursulfase) Approved in Japan for the Treatment of Hunter Syndrome 4Pharmasset Accesses up to $30 Million of Working Capital 2Pharmasset Accesses up to $30 Million of Working Capital 3
... Cy3 Ab Labeling Kit, 1 kit. ... CyDye fluorescent dyes. Conjugations are carried ... within 1 h. Dyes are packaged ... ensure consistent labelings. Category: Blotting & ...
...
Recombinant Mouse IL-23, CF...
...
Biology Products: