Navigation Links
First comprehensive genomic study of common cold reveals new treatment targets
Date:10/24/2008

lunteers (who served as the study control group) were given a sham inoculation in the form of a nasal saline spray. The volunteers were all healthy college students who signed informed consent forms. The rhinovirus-16 used in the study was first isolated and purified by Procter & Gamble and the University of Virginia.

After infection, researchers scraped small samples of nasal epithelial cells, which line the passages of the nose, from the volunteers. Rhinovirus-16 and other cold viruses infect these nasal cells, which are the body's first line of defense against airborne pathogens. The researchers then used microarray gene chip technology to compare the gene expression levels between the infected volunteers and the control group.

"Advances in genomics technology now allow us to analyze tens of thousands of genes in the same amount of time required to analyze just a handful of genes just a decade ago," said Jay Tiesman, P&G Genomics Group Leader and study author.

Forty-eight hours after inoculation, the expression of 6,530 genes in infected volunteers were significantly either up-regulated or down-regulated compared to the same genes in the control group. In other words, rhinovirus infection triggered a massive immune response in the nasal mucosa. Because rhinovirus is not as destructive as other more serious viral infections, this response appears to be disproportionate to the threat.

The researchers classified the active genes according to function, and found many involved in a process known as chemotaxis, which recruits various immune cells to the site of infection. These particular genes have been correlated with symptoms such as inflammation, congestion and runny nose. Other groups of active genes have also been classified; among them are genes which make antiviral compounds thought to help thwart infections.

"This study shows that after rhinovirus infection, cold symptoms develop because parts of our immune
'/>"/>

Contact: Shellie Byrum
sbyrum@spectrumscience.com
202-955-6222 x2516
Procter & Gamble
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Synaptics Reports Record Results for First Quarter of Fiscal 2009
2. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
3. Volcanoes may have provided sparks and chemistry for first life
4. Alzheimers disease research attracts first partner
5. Synaptics to Report First Quarter Results on October 23
6. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
7. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
8. New way to make malaria medicine also first step in finding new antibiotics
9. Whale songs are heard for the first time around New York City waters
10. ST Kinetics and NTU set up Southeast Asias first cold spray research center
11. INCF organizes the first congress dedicated to the emerging field of neuroinformatics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... that a single fungal cell or bacterial colony exerts on ... a heavy role in setting up some of the most ... be too much of a stretch to say that plants ... respond to the touch of beneficial fungi, according to a ... at the University of Wisconsin-Madison. , "Many people have ...
(Date:8/27/2014)... mysteries of the human genome was unveiled today in ... detailed comparison yet of how the genomes of the ... research, appearing August 28 in in the journal ... three species, genomes is "read out," and how their ... results add billions of entries to a publicly available ...
(Date:8/27/2014)... have identified a gene that could help scientists engineer ... in the cell membrane of plants that senses changes ... machinery accordingly. , "It,s similar to a thermostat," ... Duke. , The findings, which appear Aug. 28 ... easier to feed the world,s growing population in the ...
Breaking Biology News(10 mins):A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Water 'thermostat' could help engineer drought-resistant crops 2
... 27, 2013) A team of Korean ... the neurobehavioral function of six week-old mice ... to treat hypoxic-ischemic brain injury, and found that ... through exercise-induced fibroblast growth factor 2 (FGF2), a ...
... Researchers from Lund University, Yale University and the University of ... cuckolded males in many species still provide paternal care. When ... successful. In many species males put a lot of ... At first glance this makes no sense at all because ...
... Since its introduction fifty or so years ago, thermography has ... lameness in horses. The method is fast and safe ... body surface emits infrared radiation that can be detected by ... use. The camera produces a coloured image that shows ...
Cached Biology News:Environmental enrichment important factor impacting cell transplantation and brain repair 2Environmental enrichment important factor impacting cell transplantation and brain repair 3Why sticking around is sometimes the better choice 2Blowing in the wind: How accurate is thermography of horses' legs? 2
(Date:8/27/2014)... (PRWEB) August 27, 2014 In ... through Lawrence Livermore National Security LLC ... develop and deliver a state-of-the-art laser system for ... (ELI Beamlines), under construction in the Czech Republic. ... the laser system, called the " High repetition-rate ...
(Date:8/27/2014)... 27, 2014 The Global and China ... on the current state of the Trifluoroacetic Acid industry ... basic overview of the industry, including definitions, applications and ... market analysis are provided with a focus on history, ... comparison between the international and Chinese situation is also ...
(Date:8/27/2014)... Aug. 27, 2014  A novel biomarker for ... physicians better identify early-stage disease, when treatment can ... to a new study in The Journal of ... DGX ) and other institutions found ... outperformed conventional antibody-serum testing, including rheumatoid factor (RF) ...
(Date:8/27/2014)... 27, 2014 Flagship Biosciences LLC, a ... to the pharmaceutical and medical device industries, has announced ... fast growing company has consolidated its histology and tissue ... to Westminster, CO, just north of Denver. The ... W. 103rd Ave., Suite 100, Westminster, CO 80021 , ...
Breaking Biology Technology:LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Flagship Biosciences Announces Relocation and Expansion 2
... SAN DIEGO, Jan. 26 Amylin Pharmaceuticals, Inc.,(Nasdaq: ... P. Mihalik has been appointed,Senior Vice President, Sales ... more than 30 years of experience across multiple ... management,product launches and brand management. His career has ...
... and BINGHAM FARMS, Mich., Jan. 26 WellCentive, ... by my1HIE(sm) (My,One Health Information Exchange) as its ... Through the use of WellCentive Registry, ... providers in Southeast Michigan will be better able ...
... Sirion Therapeutics, Inc., a privately held ophthalmic-focused biopharmaceutical ... for ganciclovir ophthalmic gel, 0.15%, has been accepted for ... Sirion Therapeutics is seeking approval for ganciclovir as a ... the herpes simplex virus. The FDA has issued an ...
Cached Biology Technology:Amylin Pharmaceuticals Appoints Vincent Mihalik Senior Vice President, Sales and Marketing and Chief Commercial Officer 2Amylin Pharmaceuticals Appoints Vincent Mihalik Senior Vice President, Sales and Marketing and Chief Commercial Officer 3my1HIE(sm) Implements WellCentive Registry 2my1HIE(sm) Implements WellCentive Registry 3Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 2Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 3
S-100A10 (H-80)...
Vapor phase risers are available in various heights to accomodate a variety of inventory solutions. Risers are used to creat a false bottom in which the tanks platform rests and Liquid nitrogen is s...
... single-stranded DNA and RNA endonucleolytically to ... (DNA:DNA, DNA:RNA or RNA:RNA) are resistant ... concentrations of enzyme (1). The enzyme ... from double-stranded DNA (2), for selective ...
SP6 RNA Polymerase, 50 l, 20 U/l ,Cap Scribe Buffer, 100 l, 5x conc....
Biology Products: