Navigation Links
First comprehensive genomic study of common cold reveals new treatment targets
Date:10/24/2008

lunteers (who served as the study control group) were given a sham inoculation in the form of a nasal saline spray. The volunteers were all healthy college students who signed informed consent forms. The rhinovirus-16 used in the study was first isolated and purified by Procter & Gamble and the University of Virginia.

After infection, researchers scraped small samples of nasal epithelial cells, which line the passages of the nose, from the volunteers. Rhinovirus-16 and other cold viruses infect these nasal cells, which are the body's first line of defense against airborne pathogens. The researchers then used microarray gene chip technology to compare the gene expression levels between the infected volunteers and the control group.

"Advances in genomics technology now allow us to analyze tens of thousands of genes in the same amount of time required to analyze just a handful of genes just a decade ago," said Jay Tiesman, P&G Genomics Group Leader and study author.

Forty-eight hours after inoculation, the expression of 6,530 genes in infected volunteers were significantly either up-regulated or down-regulated compared to the same genes in the control group. In other words, rhinovirus infection triggered a massive immune response in the nasal mucosa. Because rhinovirus is not as destructive as other more serious viral infections, this response appears to be disproportionate to the threat.

The researchers classified the active genes according to function, and found many involved in a process known as chemotaxis, which recruits various immune cells to the site of infection. These particular genes have been correlated with symptoms such as inflammation, congestion and runny nose. Other groups of active genes have also been classified; among them are genes which make antiviral compounds thought to help thwart infections.

"This study shows that after rhinovirus infection, cold symptoms develop because parts of our immune
'/>"/>

Contact: Shellie Byrum
sbyrum@spectrumscience.com
202-955-6222 x2516
Procter & Gamble
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Synaptics Reports Record Results for First Quarter of Fiscal 2009
2. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
3. Volcanoes may have provided sparks and chemistry for first life
4. Alzheimers disease research attracts first partner
5. Synaptics to Report First Quarter Results on October 23
6. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
7. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
8. New way to make malaria medicine also first step in finding new antibiotics
9. Whale songs are heard for the first time around New York City waters
10. ST Kinetics and NTU set up Southeast Asias first cold spray research center
11. INCF organizes the first congress dedicated to the emerging field of neuroinformatics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
(Date:9/30/2014)... runoff in Hawaii is causing tumors in endangered sea ... published Tuesday in the peer-reviewed open-access journal PeerJ ... in algae that the turtles eat, promoting the formation ... organs. , Scientists at Duke University, the University of ... conducted the study to better understand the causes ...
(Date:9/30/2014)... available in German . ... response to risky situations such as exposure to predators. ... found in a long-term study on different populations of ... rate and ambient temperature. High metabolic rates and low ... these scenarios birds were more likely to approach potential ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2
... system cells can be genetically modified to brandish a ... kill leukemic cells. This finding, from researchers at St. ... the outcome of children who receive treatment for acute ... of the St. Jude study are published in the ...
... St. Jude Children's Research,Hospital have discovered that the ... bacteria helps these germs invade the human bloodstream. ... Journal, could help,scientists develop a vaccine that is ... The St. Jude researchers,determined the shape of a ...
... in on cancer cells spreading throughout the body, while ... whole new weapon in the fight against tough-to-treat metastatic ... researchers. , The compounds, called synthetic migrastatin analogues, prevented ... in mice, and are the first to target only ...
Cached Biology News:Genetically modified natural killer immune cells attack, kill leukemia cells 2New comparative toxicogenomics database 2New comparative toxicogenomics database 3First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers 2First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers 3
(Date:10/1/2014)... Slone Partners , a national ... and Laboratory Testing industries, reported a 120% increase in ... level and above from July 2013 to July 2014. ... of rapid breakthroughs in diagnostics, reimbursement has failed to ... been forced to fold, consolidate, or carry on without ...
(Date:10/1/2014)... Industry leaders from retail ... around the theme, ,Commercial Opportunities in the Era of ... Elsevier , a world-leading provider of scientific, ... a gathering of some of the industry,s most prominent ... today and in the future. The Elsevier ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of nature,s ... international research team led by Alejandro Briseno of ... major step in developing long-sought polymer architecture to ... use in electronic devices. , Briseno, with ... others at Stanford University and Dresden University of ...
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide ... kill nematodes. Nematodes are microscopic parasitic roundworms, found ... and inside other plants and animals. Nematicides have ... or other properties promoting migration through the soil. ... than 1,000 plant-parasitic nematodes. With more than 10,000 ...
Breaking Biology Technology:Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... Biosciences, Inc. (Nasdaq: RDEA ) announced today that ... present at the following upcoming investor conferences: ... NY. Presentation: 1:40 p.m. EST on Tuesday, November 16, 2010; and ... New York, NY. Presentation: 1:00 p.m. EST on Tuesday, November ...
... appreciate the gravity-defying grace and exquisite balance of their feline ... the way cats lap milk? Researchers at MIT, Virginia ... cats lap and found that felines of all sizes take ... The results will be published in the November 11 online ...
... is available in German . ... microelectronic components gradually being replaced by nanoelectronic ones. ... present stage the most commonly used material in ... miniaturization and technological progress. New electronic materials are ...
Cached Biology Technology:Ardea Biosciences to Present at Two Upcoming Investor Conferences 2Ardea Biosciences to Present at Two Upcoming Investor Conferences 3Cats show perfect balance even in their lapping 2Cats show perfect balance even in their lapping 3Cats show perfect balance even in their lapping 4Step by step toward tomorrow's nanomaterial 2
... scale kinase profiling, quantitative measurement of ... research built on the flexible and ... These microarrays are available as part ... - Peptide Microarray Service. ...
... acid synthetic peptide whose sequences are derived from mouse resistin protein. ... S(21) - S - M - P - L - C ... I - D - K - K - I - K ... be used for neutralization and control experiments with the polyclonal antibody ...
... peptidomimetics built on the flexible and ... These microarrays are available as part ... Service. Custom Probe Content ... specified. Thousands of customer specified peptide ...
... These extended-length microarrays are custom designed to ... configurations are available: 8,455 features per array ... 22,575 features per array (1 array/slide). ... probe length - This extended length ...
Biology Products: