Navigation Links
First child born following embryo screening with new genome analysis technique
Date:7/7/2013

London, 8 July 2013: The first birth has been achieved following the analysis of embryos using a new genome sequencing technique which promises to revolutionise embryo selection for IVF. The technique, which has never before been applied in the screening of embryos, is reported today at the annual meeting of ESHRE by Dr Dagan Wells of the NIHR Biomedical Research Centre at the University of Oxford, UK.

The analysis technique is known as "next generation sequencing", a powerful method capable of decoding entire genomes. Vast quantities of DNA data are produced from each sample tested, simultaneously revealing information on the inheritance of genetic disorders, chromosome abnormalities and mitochondrial mutations. Next generation sequencing (NGS) is already revolutionising many areas of genetic research and diagnostics, said Dr Wells, and, when applied to the assessment of embryos, will allow the concurrent analysis of serious inherited disorders and lethal chromosome abnormalities. "Next generation sequencing provides an unprecedented insight into the biology of embryos," said Dr Wells.

The identification of an embryo destined to implant in the uterus and form a pregnancy remains the holy grail of IVF. On average, only around 30% of embryos currently selected for transfer actually implant. The reason for this high failure rate is unknown, but the prime suspects are unidentified genetic or chromosomal defects. Several genetic screening methods have been introduced over the past decade, but all have been shown to have drawbacks (and have not realised their potential) when tested in randomised clinical trials. This new NGS technique developed by Dr Wells and colleagues, however, seems to overcome the major drawbacks of current methods:

  • Complete chromosome information can be produced revealing abnormalities often responsible for miscarriage
  • Serious gene defects can be identified at the same time
  • The analysis can be
    '/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. PatientStream announces the industrys first Multilingual family waiting room board
2. First-ever therapeutic offers hope for improving blood transfusions
3. World Food Prize goes to a Belgian for the first time: The scientist Marc Van Montagu
4. IQ link to babys weight gain in first month
5. First risk assessment of shale gas fracking to biodiversity
6. First international collaboration to showcase latest body of evidence of dairy health benefits
7. Non-invasive first trimester blood test reliably detects Downs syndrome
8. First evidence that the genome can adapt to temperature changes
9. First dual-action compound kills cancer cells, stops them from spreading
10. Thermal limit for animal life redefined by first lab study of deep-sea vent worms
11. Emory, Georgia Tech receive first human exposome center grant in US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Miranda, a small, icy moon of Uranus, is ... in the solar system. Despite its relatively small size, ... resurfacing that resulted in the formation of at least ... called coronae. , These coronae are visible in ... 200 km across. Arden corona, the largest, has ridges ...
(Date:9/18/2014)... many times it,s demonstrated, it,s still hard to ... But by using a signaling system called "quorum ... to suit their population. In short, some bacteria ... act accordingly. , Once the population of quorum-sensing ... innocuous to pathogenic, or from unhelpful to helpful. ...
(Date:9/18/2014)... -- Arizona turned its newborn screening program into a model ... earning it the first-ever Newborn Screening Quality Award from the ... Will Humble, M.P.H., Arizona,s Department of Health Services director, with ... established a policy of full transparency for the length of ... to the lab for analysis, and set a target of ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3
... cool movies, link at the end of the press release! ... a way to exercise a little mind control over fruit ... on command by triggering genetic "remote controls" that the scientists ... to a new report in the 8 April issue of ...
... into California's Central Valley in the last week of March ... largest migrations of the species on record, said Arthur Shapiro, ... "This may be the biggest migration of modern times," Shapiro ... of butterflies around Trona, near Death Valley, and in the ...
... For a virus to survive, it must elude the ever ... escape immune detection if it resides in nondividing cells and ... flags for immune cells. If the virus targets one of ... while latent. But some viruses, like the gamma-herpesvirus, infect B ...
Cached Biology News:Remote control flies? Fly behavior controlled by laser light 2Remote control flies? Fly behavior controlled by laser light 3Touching Molecules With Your Bare Hands 2Touching Molecules With Your Bare Hands 3
(Date:9/18/2014)... septembre 2014 Mapi, société créée à ... a été depuis 40 ans l,un des ... traditionnelles par des évaluations recentrées sur le ... impacts économiques des traitements. Logo ... A cours d,une récente conférence téléphonique avec ...
(Date:9/18/2014)... group of rare diseases that afflict skeletal growth ... hits at the fetal stage and is caused ... encoding fibroblast growth factor receptor 3 (FGFR3) has ... thanatophoric dysplasia (TD), a skeletal dysplasia that cause ... lethal, and achondroplasia (ACH), which causes stunted growth ...
(Date:9/18/2014)... the course of a day - car, phone, ... the chemical industry to turn raw materials such ... valuable chemicals that are the ingredients of life,s ... who achieved outstanding progress in driving this energy ... light instead of fossil fuels, has won the ...
(Date:9/18/2014)... 18, 2014 September 24 marks ASEA's ... ASEA is the manufacturer of the world's first and ... product, RENU28. , The Mexico City event features ... Botero, and ASEA Field Leader Shawn Catmull from Draper, ... in Atomic/Medical Physics from the University of Utah and ...
Breaking Biology Technology:1974 - 2014 - Mapi fête ses 40 ans 2Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Using solar energy to turn raw materials into ingredients for every day life 2Announcing the ASEA Mexico Grand Opening Tour Beginning September 18th 2
... Northwestern University have developed a model that will allow them ... around them. The model enables further research that may provide ... of papers are published each year that use the rat ... neural processing. Rats move their whiskers rhythmically against objects to ...
... April 7, 2011 Sangamo BioSciences, Inc. (Nasdaq: ... 6,700,000 shares of its common stock pursuant to an effective ... Inc. is the sole book-running manager in this offering and ... to purchase up to 1,005,000 additional shares. ...
... WORCESTER, Mass. and TORONTO, April 7, 2011  Generex ... that this week there will be presentations of ... the Company,s proprietary buccal insulin spray product, at ... The presentations, entitled "Use of Buccal ...
Cached Biology Technology:New model of whiskers provides insight into sense of touch 2New model of whiskers provides insight into sense of touch 3Sangamo Announces Public Offering of Common Stock 2Sangamo Announces Public Offering of Common Stock 3Generex Oral-lyn™ Data to be Presented at Two International Scientific Symposia 2Generex Oral-lyn™ Data to be Presented at Two International Scientific Symposia 3