Navigation Links
'First aid' for brain cells comes from blood
Date:4/16/2009

In acute ischemic stroke, the blood supply to the brain is restricted. Initially, brain cells die from lack of oxygen. In addition, ischemia activates harmful inflammatory processes in the affected area of the brain. For the first time, scientists at the Neurology Clinic at Heidelberg University Hospital have shown that certain immune cells in the blood inhibit inflammation after a stroke. These cells are known as regulatory T lymphocytes (Treg). The regulator cytokine Interleukin 10 plays an important role in this protection, perhaps offering a new approach to stroke therapy. The study has now been published in Nature Medicine.

Every year, some 200,000 people suffer a stroke in Germany. It is still frequently fatal or causes severe disability. The Neurology Clinic in Heidelberg under the direction of its medical director Professor Dr. Werner Hacke is one of the most prestigious centers in the world for developing and testing innovative approaches to stroke treatment.

Immune cells produce the protective Interleukin 10

The team of researchers headed by Dr. Roland Veltkamp, senior physician at the Neurology Clinic of Heidelberg University Hospital has now shown in stroke models that a stroke in mice with no functioning Treg cells in their blood causes much greater damage to the brain and greater disabilities than in animals with functioning Treg cells. An analysis of the immune system showed that mice without this cellular "First Aid" produce much more inflammatory transmitters in the brain and blood. In addition, immune cells, whose task is to recognize and digest foreign bodies or dead cell material e.g. microglial cells or neutrophils are activated more strongly in the absence of Treg.

Treg cells protect cells by suppressing the harmful activation of the immune system and can thus also prevent autoimmune diseases from developing. It is still unclear how exactly the Treg cells communicate in the damaged brain tissue. Interleukin 10 (IL 10), a transmitter substance that is produced by the Treg cells, seems to play an important role during a stroke. Mice with no functioning Treg cells that were injected with IL 10 on the first day following a stroke had markedly less brain damage than mice that did not receive IL 10. On the other hand, the transfer of genetically modified Treg cells unable to produce IL-10 offered no protection.

The researchers in Heidelberg are now working on different approaches for translating the protective mechanisms of Treg into future treatment for strokes. "We still need to know a lot more about how the immune cells communicate among themselves and with the brain cells after a stroke in order to develop a treatment plan for patients," says Dr. Roland Veltkamp.


'/>"/>

Contact: Dr. Roland Veltkamp
Roland.Veltkamp@med.uni-heidelberg.de
062-215-67504
University Hospital Heidelberg
Source:Eurekalert

Related biology news :

1. Which came first, the moth or the cactus?
2. First all-African GM crop is resistant to maize streak virus
3. Scientists retrace evolution with first atomic structure of an ancient protein
4. CU-Boulder team discovers first ancient manioc fields in Americas
5. First finding of a metabolite in 1 sex only
6. First orchid fossil puts showy blooms at some 80 million years old
7. First individual genome sequence published
8. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
9. UNH becomes first university in nation to use landfill gas as primary energy source
10. Scientists in first global study of poison gas in the atmosphere
11. Weight gain between first and second pregnancies associated with increased odds of male second child
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/22/2016)... , March 22, 2016 ... research report "Electronic Sensors Market for Consumer Industry by ... & Others), Application (Communication & IT, Entertainment, ... - Global Forecast to 2022", published by ... is expected to reach USD 26.76 Billion ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of 8.5 ... end machines that use the more unconventional z-dimension of 20mm. Z-dimension or ... the cuvette holder. , FireflySci has developed several Agilent flow cell product lines ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
Breaking Biology Technology: