How do one-celled parasites move from the salivary gland of a mosquito through a person's skin into red blood cells? What molecular mechanisms form the basis for this very important movement of the protozoa? A team of researchers headed by Dr. Friedrich Frischknecht, head of a research group at the Department of Infectious Diseases at Heidelberg University Hospital, observed the initial stage of the malaria parasite that is transmitted by mosquitoes with new microscope techniques. They discovered that the parasite continually alternates between phases of rapid gliding and phases of firm adhesion to the surface. The interaction of these two processes probably enables the parasite to move rapidly over a long time, which is necessary for successful transmission of the disease. The research was a colaboration within the CellNetworks cluster of excellence and published in the prestigious journal Cell Host & Microbe.
The CellNetworks cluster of excellence
Researchers from three different disciplines at the CellNetworks cluster of excellence were involved in the study. This is one of the first studies ever in which modern biophysical methods were used to examine parasites. Leading this study were, in addition to Dr. Friedrich Frischknecht of the Parasitology Department, Professor Dr. Ulrich Schwarz from the Institute of Theoretical Physics and Professor Dr. Joachim Spatz from the Institute of Biophysical Chemistry at the University of Heidelberg.
The goal of the CellNetworks cluster of excellence is to describe and understand complex biological networks. It consists of numerous scientific institutions in the Mannheim/Heidelberg region and was founded at the University of Heidelberg in 2006 as part of the excellence initiative of the Deutsche Forschungsgemeinschaft (German Research Foundation) as one of the first excellence institutions in Germany.
How does the motility mechanism of the malaria parasite function
|Contact: Dr. Friedrich Frischknecht|
University Hospital Heidelberg