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Findings uncover new details about mysterious virus
Date:4/28/2009

ealed that one side of the virus's capsid is slightly different than the others, whereas all sides are the same in a regular icosahedron.

An icosahegron has a roughly spherical shape containing 20 triangular facets and 60 identical subunits. Like an icosahedron, the mimivirus capsid also has 20 facets. However, unlike an icosohedron, five facets of the capsid are slightly different than the others and surround the special vertex. Icosohedra contain 12 similar vertices, whereas the mimivirus contains eleven such vertices, with the 12th being different than the others.

The new reconstructed picture of the virus matched features seen using the atomic force microscope picture, Rossmann said.

The starfish-shaped feature apparently opens up like a blooming flower when the virus is ready to infect its host amoeba, enabling the virus to eject its DNA for insertion into the host, Rossmann said.

"In addition, we think the indentation of the genetic material has something to do with how the genome comes out of the virus," he said. "There is a relationship between the shape of the genome and the special vertex."

The research, which is funded by the National Institutes of Health, is ongoing, with future work probing additional properties of the virus, particularly the structure of the starfish-shaped feature and how it functions.

The paper was written by Xiao; microscope expert Yurii G. Kuznetsov in the Department of Molecular Biology and Biochemistry at UC Irvine; Sun; postdoctoral research associates Susan L. Hafenstein and Victor A. Kostyuchenko and electron microscopist Paul R. Chipman, from Purdue; research scientist Marie Suzan-Monti and Didier Raoult, a professor of microbiology, both from the University of the Mediterranean; Alexander McPherson, a professor of molecular biology and biochemistry at UC Irvine; and Rossmann.


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Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert

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