Navigation Links
Findings to help in design of drugs against virus causing childhood illnesses
Date:3/21/2013

nhibiting infection. In the new work, the researchers obtained a near-atomic-scale resolution three-dimensional structure of enterovirus 71 binding with an inhibitor called WIN 51711.

"We show that the compound stabilizes the virus and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release," Rossmann said. "Our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs."

At a resolution of 3.2 angstrom, the images show nearly atomic-scale structural features.

Hand, foot and mouth disease, an infection most common among young children, sometimes arises in a daycare setting. Of the 427,278 cases of the disease recorded in mainland China between January and May 2010, 5,454 cases were classified as severe, with 260 deaths, according to the World Health Organization.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert

Page: 1 2

Related biology news :

1. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
2. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
3. New findings on protein misfolding
4. New findings on gene regulation and bone development
5. Verinata Health Announces New Findings At The American Society Of Human Genetics
6. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
7. The findings between DNMs and autism provides global view of mutability on human diseases
8. New findings in the search for genetic clues to insulin production
9. ACMG releases report on incidental findings in clinical exome and genome sequencing
10. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
11. Report presents designs for study of cancer risks near US nuclear facilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... is tricky enough. Knowing what causes them at the ... of Iowa researchers have created the most detailed map ... long associated with blinding diseases, such as age-related macular ... in the choroid, which supplies blood and oxygen to ... differences in the abundance of proteins in different areas ...
(Date:8/1/2014)... 2014Biologists at The Scripps Research Institute (TSRI) have identified ... process in brown fat cells. , The study, ... of the Proceedings of the National Academy of ... "brown fat thermogenesis," which is of great interest to ... may also protect against diabetes. , "This finding offers ...
(Date:7/31/2014)... a decade ago, prestin was found to be a key ... protein found in the hair cells of the inner ear ... the cochlea, like an antique phonograph horn, amplify sound waves ... new study published in the advanced online edition of ... shown that prestin has also independently evolved to play a ...
Breaking Biology News(10 mins):A map for eye disease 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3
... 2013: Phthalates are among a group of industrial ... on reproductive health and development, particularly in the,male. ... "endocrine disruptors", and proposed as,one of several possible ... They are,classified in two groups - high molecular ...
... for the production of renewable and clean energy, photoelectrochemical ... PECs are devices able of splitting water molecules into ... solar radiation. "As a matter of fact, we,ve already ... the Laboratory of Photonics and Interfaces (LPI) at EPFL ...
... of Toronto-based researchers may be one step closer to a ... research and therapy. Induced pluripotent stem cells (iPSCs) can ... flexibly develop into many different types of cells. However, producing ... generation are largely unknown. But researchers from the University ...
Cached Biology News:Adverse effects of phthalates on ovarian response to IVF 2Champion nano-rust for producing solar hydrogen 2Toronto team IDs proteins key in stem cell production 2
(Date:8/1/2014)... This is a professional and in-depth study on ... Global and China. The report provides a basic overview ... structure. Global market analysis and Chinese domestic market analysis ... and competitive landscape of the market. A comparison between ... The report also focuses on development policies and plans ...
(Date:8/1/2014)... 1. 2014 As one of the 10 ... Annual Meeting & Clinical Lab Expo is the place ... are introduced to the healthcare world. This year, many ... exhibitors will include the latest diagnostic technology in the ... smartphones and biosensors have enabled the development of "labs-on-a-chip" ...
(Date:8/1/2014)... , Aug. 1, 2014 The  PROPEL Center ... number and success rate of early-stage life sciences companies ... it has awarded 15 grants to help ... The MedTech Conference   in Chicago ... conference in North America , bringing ...
(Date:8/1/2014)... 01, 2014 Once a decision has ... This webinar will discuss how to define your tolerance ... speakers Bob Allen, Senior Director of Facilities Integration at ... at Fluor Industrial Services, and special guest Carrier Li, ... at Amgen, as they provide an examination of the ...
Breaking Biology Technology:Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 3Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 4Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2
... , BONITA SPRINGS, Fla., Nov. ... and the technology group The Linde Group ... in order to identify the optimum management of carbon ... and photobioreactor technology. This cooperation will see the companies ...
... , , TUSTIN, Calif., Nov. 18 ... announced that researchers presented positive data on progress in ... confirming that its phosphatidylserine (PS)-targeting antibodies bind to VHF ... a model of lethal VHF infection. The data ...
... ... conference will demonstrate how our military trains for irregular warfare--for combat, and just as ... populations in Orlando, FL on November 30 to December 3. , ... Orlando, FL (Vocus) November 18, 2009 ...
Cached Biology Technology:Algenol Biofuels and The Linde Group Agree To Cooperate in CO2 and O2 Management For Biofuel Production From Algae 2Algenol Biofuels and The Linde Group Agree To Cooperate in CO2 and O2 Management For Biofuel Production From Algae 3Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 2Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 3Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 4Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 5Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 6Huge Exhibition to Demonstrate Training for Irregular Warfare 2Huge Exhibition to Demonstrate Training for Irregular Warfare 3
... Thermo has established an expertise in ... both for solid support synthesis and synthesis ... controlled by Mass Spectrometry and analytical HPLC ... provide products that meet the highest quality ...
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... dispensers save space and organize ... and other garb. They are ... for small parts used in ... acrylic. Many other sizes and ...
Biology Products: