Navigation Links
Findings suggest new cause, possible treatment for multiple sclerosis
Date:11/23/2010

WEST LAFAYETTE, Ind. - Researchers have found evidence that an environmental pollutant may play an important role in causing multiple sclerosis and that a hypertension drug might be used to treat the disease.

The toxin acrolein was elevated by about 60 percent in the spinal cord tissues of mice with a disease similar to multiple sclerosis, said Riyi Shi, a medical doctor and a professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering.

The research results represent the first concrete laboratory evidence for a link between acrolein (pronounced a-KRO-le-an) and multiple sclerosis, he said.

"Only recently have researchers started to understand the details about what acrolein does to the human body," Shi said. "We are studying its effects on the central nervous system, both in trauma and degenerative diseases such as multiple sclerosis."

The compound is an environmental toxin found in air pollutants including tobacco smoke and auto exhaust. Acrolein also is produced within the body after nerve cells are damaged. Previous studies by this research team found that neuronal death caused by acrolein can be prevented by administering the drug hydralazine, an FDA-approved medication used to treat hypertension.

The new findings show that hydralazine also delays onset of multiple sclerosis in mice and reduces the severity of symptoms by neutralizing acrolein.

"The treatment did not cause any serious side effects in the mice," Shi said. "The dosage we used for hydralazine in animals is several times lower than the standard dosing for oral hydralazine in human pediatric patients. Therefore, considering the effectiveness of hydralazine at binding acrolein at such low concentrations, we expect that our study will lead to the development of new neuroprotective ther
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Biomedical and health professionals converge in D.C. to absorb new findings in science of informatics
2. Unexpected findings of lead exposure may lead to treating blindness
3. Gynecologist disputes findings
4. New findings pull back curtain on relationship between iron and Alzheimers disease
5. MBL scientists reveal findings of World Ocean Microbe Census
6. New VARI findings next step to growing drought-resistant plants
7. Findings overturn old theory of phytoplankton growth, raise concerns for ocean productivity
8. Scripps Research study overturns decade-old findings in neurobiology
9. NIDCD-funded chemosensory researchers present findings at AChemS 2010 Meeting
10. New findings on taste and smell
11. Significant findings about protein architecture may aid in drug design, generation of nanomaterials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Findings suggest new cause, possible treatment for multiple sclerosis
(Date:9/16/2014)... , Sept. 16, 2014  Cross Match ... management solutions, announced today the launch of its ... authenticate the identity of an individual using their ... Verifier Sentry rapidly reads credential documents with embedded ... by matching the biometric to a live scan ...
(Date:9/15/2014)... 15, 2014) The so-called central dogma of ... long provided a simplified explanation for how genetic ... , In reality, of course, the process ... articulated nearly 60 years ago by Nobel Laureate ... For one, there are multiple types of RNA, ...
(Date:9/15/2014)... research has determined that a single group of microorganisms ... B12 production in the oceans, with implications for the ... B12 is an essential molecule required by most life ... relatively small group of microorganisms because it is so ... key role in maintaining the brain and nervous systems, ...
Breaking Biology News(10 mins):Cross Match Launches New Identity Management Handheld Solution 2Scientists discover RNA modifications in some unexpected places 2Researchers discover new producer of crucial vitamin 2
... application of biosolids (treated municipal sewage sludge) is a ... plant nutrients and organic matter. However, the presence of ... that farmland application may result in accumulation of dioxins ... food chain because several congeners of dioxins have extremely ...
... remotely piloted aircraft carrying a NASA sensor flew over ... will be used to help fight more than 300 ... for next week. The flights by NASA,s ... Scanner developed at NASA,s Ames Research Center at Moffett ...
... In one of the first studies to link ... published in the August issue of the ... serious and violent delinquencythat gain predictive precision when ... friends and school processes. Sociologists from the ...
Cached Biology News:Dioxin risk in soil and plant tissues after long-term biosolids application 2NASA responds to California wildfire emergency imaging request 2NASA responds to California wildfire emergency imaging request 3Sociological research shows combined impact of genetics, social factors on delinquency 2
(Date:9/16/2014)... RENU 28, the world's first and only skin ... purchase in Australia and New Zealand in mid-August . , ... The tour will make stops in Brisbane on September 16, ... Sydney on the 20th, and Melbourne on the 22nd. , ... and to educate people about the new product and business ...
(Date:9/15/2014)... 2014 Cancer Immunotherapy Market ... T-cell Therapies is a new market research report ... three principal types of therapeutics that have become ... cancer immunotherapy (which is often called "immuno-oncology") in ... Adoptive cellular immunotherapy. , The regular use ...
(Date:9/15/2014)... developed a technique for controlling the surface tension of ... door to a new generation of reconfigurable electronic circuits, ... fact that the oxide "skin" of the metal ... a surfactant, lowering the surface tension between the metal ... liquid metal alloy of gallium and indium. In base, ...
(Date:9/15/2014)... Northeastern University has developed a novel method for ... of nanocarbon structures in carbon nanotube arrays. The ... allow the researchers to tailor the physical properties ... from electronic devices to CNT-reinforced composite materials found ... Their findings were published in the journal ...
Breaking Biology Technology:Global Wellness Company Hosts ASEA Australia Tour September 16-22 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 4Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 5Researchers control surface tension to manipulate liquid metals 2Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2
... Pa. , Feb. 2 Fibrocell Science, ... on the development of regenerative cell therapy for aesthetic, ... Pernock , Chairman of the Board of Directors, has ... most recently served as Senior Vice President (SVP), Pharmaceuticals, ...
... , LIVERPOOL, February 2 ... Cambian healthcare Noel Tracey to lead its,expanding Community ... Noel has more than 15 years, experience of senior management ... In his previous role as,director of operations at Cambian Healthcare, ...
... ... the life of the International Space Station (ISS) to 2020 or beyond. , ... (Vocus) February 1, 2010 -- Astrogenetix is ... Station (ISS) to 2020 or beyond. , ,Thomas B. Pickens III, Chairman of Astrogenetix, Inc.:, ...
Cached Biology Technology:Fibrocell Science, Inc. Names David Pernock Chief Executive Officer 2Fibrocell Science, Inc. Names David Pernock Chief Executive Officer 3Noel Tracey to Head Up Gray Healthcare Recovery Team 2Astrogenetix Statement On Nasa's Fiscal Year 2011 Budget Announcement 2
...
Request Info...
Request Info...
... KingFisher magnetic particle based purification systems provide ... from any sample. They offer increased throughput ... three systems- KingFisher, KingFisher mL and KingFisher ... 1000 l. Each system consists of an ...
Biology Products: