Navigation Links
Findings suggest new cause, possible treatment for multiple sclerosis
Date:11/23/2010

WEST LAFAYETTE, Ind. - Researchers have found evidence that an environmental pollutant may play an important role in causing multiple sclerosis and that a hypertension drug might be used to treat the disease.

The toxin acrolein was elevated by about 60 percent in the spinal cord tissues of mice with a disease similar to multiple sclerosis, said Riyi Shi, a medical doctor and a professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering.

The research results represent the first concrete laboratory evidence for a link between acrolein (pronounced a-KRO-le-an) and multiple sclerosis, he said.

"Only recently have researchers started to understand the details about what acrolein does to the human body," Shi said. "We are studying its effects on the central nervous system, both in trauma and degenerative diseases such as multiple sclerosis."

The compound is an environmental toxin found in air pollutants including tobacco smoke and auto exhaust. Acrolein also is produced within the body after nerve cells are damaged. Previous studies by this research team found that neuronal death caused by acrolein can be prevented by administering the drug hydralazine, an FDA-approved medication used to treat hypertension.

The new findings show that hydralazine also delays onset of multiple sclerosis in mice and reduces the severity of symptoms by neutralizing acrolein.

"The treatment did not cause any serious side effects in the mice," Shi said. "The dosage we used for hydralazine in animals is several times lower than the standard dosing for oral hydralazine in human pediatric patients. Therefore, considering the effectiveness of hydralazine at binding acrolein at such low concentrations, we expect that our study will lead to the development of new neuroprotective ther
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Biomedical and health professionals converge in D.C. to absorb new findings in science of informatics
2. Unexpected findings of lead exposure may lead to treating blindness
3. Gynecologist disputes findings
4. New findings pull back curtain on relationship between iron and Alzheimers disease
5. MBL scientists reveal findings of World Ocean Microbe Census
6. New VARI findings next step to growing drought-resistant plants
7. Findings overturn old theory of phytoplankton growth, raise concerns for ocean productivity
8. Scripps Research study overturns decade-old findings in neurobiology
9. NIDCD-funded chemosensory researchers present findings at AChemS 2010 Meeting
10. New findings on taste and smell
11. Significant findings about protein architecture may aid in drug design, generation of nanomaterials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Findings suggest new cause, possible treatment for multiple sclerosis
(Date:10/30/2014)... – Bacteria in the gastrointestinal tract fulfill many ... these same bacteria can induce strong inflammatory responses ... gut and enter the bloodstream. , Although acute ... body, chronic or systemic inflammation is linked to ... the involvement of inflammatory processes in the development ...
(Date:10/30/2014)... 2014  Securus Technologies, a leading provider ... for public safety, investigation, corrections and monitoring, ... enhancements to its THREADS™ product, which utilizes ... intelligence and focused leads for investigators. ... innovation through identifying and delivering solutions serving ...
(Date:10/29/2014)... its kind to date, researchers have used DNA sequencing ... for autism. Joseph Buxbaum, Ph.D., Icahn School of Medicine ... Broad Institute of Harvard and MIT, and their colleagues ... parents and unrelated people. They identified changes in 107 ... for autism spectrum disorder (ASD) – a jump from ...
Breaking Biology News(10 mins):Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2
... Institute for Research in Immunology and Cancer (IRIC) at ... quantity of laboratory stem cells from a small number ... multidisciplinary team, directed by Dr. Guy Sauvageau, thus took ... treatment based on these stem cells. This worldwide first ...
... kind study examining the effects of methamphetamine use during pregnancy ... in children. The research is published in the April 15, ... of the American Academy of Neurology. "Methamphetamine ... leading to an increasing number of children with prenatal meth ...
... In acute ischemic stroke, the blood supply to the ... of oxygen. In addition, ischemia activates harmful inflammatory processes ... first time, scientists at the Neurology Clinic at Heidelberg ... the blood inhibit inflammation after a stroke. These cells ...
Cached Biology News:World premiere in stem cell research in Montreal 2Prenatal meth exposure linked to abnormal brain development 2'First aid' for brain cells comes from blood 2
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
(Date:10/27/2014)... 2014 The report “Smart Highway ... Management, Communication, Monitoring), and by Display (Variable Message ... segments the global market into various sub-segments with ... identifies the drivers and restraints for this market ... Browse 75 market tables and 37 figures spread ...
(Date:10/27/2014)... Pa. , Oct. 27, 2014 ... Foundation of America (CCFA) announced today the launch ... , an educational campaign designed to ... diseases (IBD) on the paired role of nutrition ... To view the multimedia assets associated with this ...
(Date:10/26/2014)... The report "Data Center Networking ... Equipment, WAN Optimization Appliances]: Global Advancements, Worldwide Forecasts ... center networking market into various segments with an ... also identifies the factors driving this market, various ... with the future roadmaps. , Browse 106 market ...
Breaking Biology Technology:SoundConnect Unveils Q4 Partner Incentives 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4
... Wis. - Building efficiency and power solutions giant ... of its executive positions reflecting the creation an Executive ... president, was named chairman of the EOC, a committee ... since 1982, Roell served as vice president and chief ...
... at a Pennsylvania teaching and research hospital are integrating ... to distribute information about diabetes, cancer, heart disease, and ... S. Hershey Medical Center recently purchased the Web-based ... forums, and internal staff meetings to medical students and ...
... is a concept that appears a long way from ... genetic-based medicine is closer than we think. , ,In ... identify the patient's predisposition to various diseases, and to ... environmental characteristics. , , Stephens Cracking ...
Cached Biology Technology:Medical College researcher working to make genetic-based medicine a reality 2Medical College researcher working to make genetic-based medicine a reality 3
... Facility , Galaxy LIMS, Sophisticated Bioinformatics , ... scientists ,We offer individual sample sequencing of ... for single or double strand publication quality. ... DNA of interest is 1.3 to 7 ...
... sequencing of individual research samples, including PCR ... Agencourt's world-class, high performance sequencing pipeline processes ... The key benefits of Agencourt's QuickLane ... 48 hour sample turnaround, industry leading sequence ...
Shotgun library construction and high-throughput DNA sequencing of microbial genomes, BACs, adenoviruses, phosmids and cosmids. LIMS tracking utilizing Geospiza's Finch system....
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
Biology Products: