Findings show nanomedicine promising for treating spinal cor...(ations required. With the micelles ...)

"With the micelles, you need only about 1/100,000th the concentration of regular polyethylene glycol," Cheng said.

Ongoing research at Purdue has shown the benefits of polyethylene glycol, or PEG, to treat animals with spinal cord injuries. The work is led by Richard Borgens, director of the Center for Paralysis Research and the Mari Hulman George Professor of Neurology in the School of Veterinary Medicine.

Findings have shown that PEG specifically targets damaged cells and seals the injured area, reducing further damage. It also helps restore cell function.

The new findings were made possible by the interdisciplinary nature of the work, which involves Borgens and other Purdue researchers, Cheng said. The collaboration included Borgens; Riyi Shi, an associate professor of biomedical engineering and basic medical sciences; and Kinam Park, Showalter Distinguished Professor of Biomedical Engineering and a professor of pharmaceutics.

Findings showed that cores made of particular materials work better than others at restoring function to damaged axons, which are slender extensions of nerve cells.

The research also showed that without the micelles treatment about 18 percent of axons recover in a segment of damaged spinal cord tested in a "double sucrose gap recording chamber." The micelles treatment boosted the axon recovery to about 60 percent. The researchers used the chamber to study how well micelles repaired damaged nerve cells by measuring the "compound action potential," or the ability of a spinal cord to transmit signals.

The experiment mimics what happens during a traumatic spinal cord injury. Findings showed that micelles might be used to repair axon membranes damaged by compression injuries, a common type of spine injury.

The researchers also tracked dyed micelles in rats, demonstrating that the nanoparticles were successfully delivered to injury sites. Findings also showed
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