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Findings show insulin -- not genes -- linked to obesity
Date:4/14/2009

dal imaging system allows us to correlate different events, like fat storage, gene expression and insulin signaling," Le said. "We can monitor these different events at the same time, and that's why we can determine the mechanism at the single-cell level."

Insulin attaches to binding sites on cell membranes, signaling the cells to take up glucose from the blood. Cells that are said to be resistant to insulin fail to take up glucose, the primary cause of Type II diabetes, a medical condition affecting nearly 24 million Americans. About two-thirds of U.S. adults are overweight, and nearly one-third obese.

The research, which has been funded by the National Institutes of Health, is ongoing. Future work may seek to pinpoint specific events in the insulin-signaling cascade that are responsible for fat storage.


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Contact: Emil Venere,
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2 3

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