Navigation Links
Findings show insulin -- not genes -- linked to obesity
Date:4/14/2009

WEST LAFAYETTE, Ind. - Researchers have uncovered new evidence suggesting factors other than genes could cause obesity, finding that genetically identical cells store widely differing amounts of fat depending on subtle variations in how cells process insulin.

Learning the precise mechanism responsible for fat storage in cells could lead to methods for controlling obesity.

"Insights from our study also will be important for understanding the precise roles of insulin in obesity or Type II diabetes, and to the design of effective intervention strategies," said Ji-Xin Cheng, an assistant professor in Purdue University's Weldon School of Biomedical Engineering and Department of Chemistry.

Findings indicate that the faster a cell processes insulin, the more fat it stores.

Other researchers have suggested that certain "fat genes" might be associated with excessive fat storage in cells. However, the Purdue researchers confirmed that these fat genes were expressed, or activated, in all of the cells, yet those cells varied drastically - from nearly zero in some cases to pervasive in others - in how much fat they stored.

The researchers examined a biological process called adipogenesis, using cultures of a cell line called 3T3-L1, which is often used to study fat cells. In adipogenesis, these cells turn into fat.

"This work supports an emerging viewpoint that not all biological information in cells is encoded in the genetic blueprint," said Thuc T. Le, a National Institutes of Health postdoctoral fellow at Purdue who is working with Cheng. "We found that the variability in fat storage is dependent on how 3T3-L1 cells process insulin, a hormone secreted by the pancreas after meals to trigger the uptake of glucose from the blood into the liver, muscle or fat cells."

The findings are detailed in a research paper appearing online in the journal PLoS ONE, published by the Public Library of Science, a non-p
'/>"/>

Contact: Emil Venere,
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New prostate cancer research findings
2. K-State researchers findings on E. coli
3. UVA reports surprising findings related to myotonic muscular dystrophy
4. Womens health-related scientific findings presented by University of Pittsburgh researchers
5. Findings a step toward making new optical materials
6. Pioneering landscape-scale research releases first findings
7. Findings released from 1 of the largest percutaneous coronary intervention trials ever
8. Study findings show infection control intervention helps keep kids in school
9. New findings on immune system in amphibians
10. International conference to release new findings on smell and taste
11. Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Findings show insulin -- not genes -- linked to obesity
(Date:5/11/2015)... -- Curemark LLC, a privately held drug research and ... III double blind, randomized, placebo-controlled clinical trial to examine ... children ages 3-8 with Autism. Previously, Curemark announced the ... clinical trial for CM-AT in children ages 3-8 with ... chymotrypsin. This new trial will help determine whether all ...
(Date:5/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, reminds investors and media that  Mr. David ... CARTES SECURE CONNEXIONS AMERICA 2015, held in Washington ... three-day conference is organized into a series of nine session ... Global Fraud: Where is the Trust in Cyberspace? and ...
(Date:4/20/2015)... PASADENA, Calif. , April 20, 2015 ... San Gabriel Valley to implant a new miniaturized, wireless ... HF System is the first and only FDA-approved heart ... reduce hospital admissions when used by physicians to manage ... a sensor that is implanted in the pulmonary artery ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... fail to produce fertile hybrids? A new study led ... shows that differences in the levels - not necessarily ... in mediating reproductive isolation. Two individuals are defined ... between them give rise to viable and fertile offspring. ...
... TX--The Agricultural Research Service of the U.S. Department of ... Sciences of Texas A&M University recently announced the release ... hybrid pepper ( Capsicum chinense Jacq.). ... Vegetable and Fruit Improvement Center, open-pollinated cultivars of Habanero ...
... PROVINCE, CHINA--Zinc is vital for the healthy growth and reproduction ... in essential functions such as carbohydrate metabolism, photosynthesis, and sugar ... fruits, tends to be highly susceptible to zinc deficiency. A ... using zinc sprays at critical stages on apple trees in ...
Cached Biology News:Origin of species: Protein imbalances doom hybrids 2'CaroTex-312,' new Habanero-type pepper introduced 2Zinc sulfate, sugar alcohol zinc sprays improve apple quality 2
(Date:5/28/2015)... 2015 RXi Pharmaceuticals Corporation (NASDAQ: RXII ... innovative therapeutics, primarily in the areas of dermatology and ... of 26 million units at a price to the ... approximately $10.4 million. Each unit consists of (i) one ... right to purchase 0.50 of a share of common ...
(Date:5/28/2015)... 28, 2015 CD-adapco, the largest ... software, announced today it is joining the consortium ... provide state-of-the-art engineering simulation tools for analyzing particle ... and experiences in analyzing particle flow that will ... advance the understanding of flow modeling solutions. , ...
(Date:5/28/2015)... York, NY (PRWEB) May 28, 2015 ... renewed and enhanced its long term partnership with PTI ... work together to provide clients with custom-tailored method ... the art instruments currently available. The agreement includes a ... companies’ employees across organizational lines. This enables a ...
(Date:5/28/2015)... Virginia (PRWEB) May 28, 2015 ... LLC announced today that Roger L. Williams, MD, ... consultant. NDA Partners Premier Experts are top tier ... to bring extraordinary value to the company’s clients. ... solutions to help clients successfully develop their medical ...
Breaking Biology Technology:RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2
... Epeius Biotechnologies,Corporation today announced the publication of ... medical gene delivery. The,latest scientific paper, entitled ... generation of targeted gene delivery vectors enables,personalized ... the October,issue of the International Journal of ...
... Pa., Oct. 6 Environmental,Tectonics Corporation,s (Amex: ... today announced the sale of two (2) BARA-MED(R) ... Livingston,NJ., ETC is delighted to work with ... hospital. The 597-bed institution,is one of the largest ...
... Caprion Proteomics Inc. announced,today that it has been awarded ... and Infectious Diseases (NIAID), a part of the US,National ... the area,of infectious disease biomarkers., Under the contract ... as one of two NIAID Clinical Proteomics Centers for ...
Cached Biology Technology:Targeting Metastatic Cancer From the Inside: Epeius Biotech Reveals a New Generation of Tools for Medical Gene Delivery 2Environmental Tectonics Corporation Announces the Placement of Two Monoplace Hyperbaric Chambers at Saint Barnabas Medical Center in New Jersey 2Environmental Tectonics Corporation Announces the Placement of Two Monoplace Hyperbaric Chambers at Saint Barnabas Medical Center in New Jersey 3Environmental Tectonics Corporation Announces the Placement of Two Monoplace Hyperbaric Chambers at Saint Barnabas Medical Center in New Jersey 4Caprion Awarded US $12.9M Infectious Disease Biomarker Research Contract 2
... IT siRNA Tracker Intracellular Localization Kit provides ... and deliver siRNA, of your design, in ... vitro tracking experiments. Subcellular localization and functional ... monitored following introduction of the labeled siRNA ...
... IT siRNA Tracker Intracellular Localization Kit provides ... and deliver siRNA, of your design, in ... vitro tracking experiments. Subcellular localization and functional ... monitored following introduction of the labeled siRNA ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... (ECM) is an important step in tumor ... adhering to and spreading along the blood ... MMP collagenases, dissolve tiny holes in the ... vessels to allow cancer cells to invade.,The ...
Biology Products: