Navigation Links
Findings point to potential treatment for virus causing childhood illnesses
Date:1/29/2014

WEST LAFAYETTE, Ind. - Researchers have discovered a potential treatment for a viral infection that causes potentially fatal brain swelling and paralysis in children. The findings also point to possible treatments for related viruses including those that cause "common cold" symptoms.

The virus, called enterovirus 71 (EV71), causes yearly outbreaks of hand, foot, and mouth disease in Southeast Asian countries including China and Malaysia. Some of the infected children develop encephalitis that can be fatal or result in permanent brain damage. There are no anti-EV71therapeutic agents available.

The researchers prepared antibodies by immunizing mice with immature EV71 particles. Antibodies generated by this immunization induced a change in the mature EV71 virus, rendering it non-infectious by causing the virus particles to lose their genome.

The findings reveal a potential treatment mechanism, demonstrating that the antibody, called E18, has potential as an anti-EV71 therapy, said Michael G. Rossmann, Purdue's Hanley Distinguished Professor of Biological Sciences.

Findings are being reported this week in Proceedings of the National Academy of Sciences. The paper was authored by Purdue postdoctoral research associate Pavel Plevka; Pei-Yin Lim, a researcher from Sentinext Therapeutics in Penang, Malaysia; Purdue research scientist Rushika Perera; Jane Cardosa, a researcher at Sentinext and MAB Explorations in Malaysia; Purdue graduate student Ampa Suksatu; Richard J. Kuhn, a professor and head of Purdue's Department of Biological Sciences; and Rossmann.

EV71 belongs to a family of viruses called picornaviruses, pathogens that cause diseases including common-cold-like illnesses and poliomyelitis in people and chronic infections in livestock.

"The antibody-mediated virus neutralization by the induction of genome release has not been previously demonstrated," Rossmann said. "These results indicate that antibod
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
2. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
3. New findings on protein misfolding
4. New findings on gene regulation and bone development
5. Verinata Health Announces New Findings At The American Society Of Human Genetics
6. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
7. The findings between DNMs and autism provides global view of mutability on human diseases
8. New findings in the search for genetic clues to insulin production
9. ACMG releases report on incidental findings in clinical exome and genome sequencing
10. Findings to help in design of drugs against virus causing childhood illnesses
11. Surprising findings on hydrogen production in green algae
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Findings point to potential treatment for virus causing childhood illnesses
(Date:9/16/2014)... associated with increased rates and intensity of tobacco smoking. ... relationship between schizophrenia and smoking stems, in part, from ... symptoms and cognitive impairment associated with the disease. , ... Biological Psychiatry , sheds light on this hypothesis. ... in the brain was lower in schizophrenia patients than ...
(Date:9/16/2014)... . CRG researchers ... Journal of Cell Biology describes how Topo 2 ... , At this very moment thousands of our body,s cells ... the body repairs damaged tissues and regenerates others like skin ... "mitosis", during which the cell duplicates its genetic material and ...
(Date:9/16/2014)... Valdez spilled 11 million gallons of oil into Alaska,s ... giant oil spill in the Gulf of Mexico in ... Journal of Consumer Research , news coverage of environmental ... catalyzing changes in the way fossil fuels are used. ... of these two events helped to resolve many of ...
Breaking Biology News(10 mins):Smoking and schizophrenia linked by alterations in brain nicotine signals 2Unraveling cell division 2Unraveling cell division 3Exxon Valdez 2014: Does media coverage of manmade disasters contribute to consumer complacency? 2
... A new book featuring a series of interviews ... available from the Inter-American Network of Academies of Sciences ... highlights the inclusion and empowerment of women in science ... Juan Pedro Laclette say in the book,s introduction that ...
... March 8, 2013 Dr. Eric Olson , chairman ... 2013 recipient of the March of Dimes Prize in Developmental ... the heart and other muscles. His work is credited ... could lead to novel treatments for heart disease and muscle ...
... a new method for attaching proteins to the surface ... membrane proteins. This enables time-resolved tracking of the interactions ... is accurate down to atomic resolution. The method is ... K4DD", in which scientists explore the interplay of drugs ...
Cached Biology News:New book celebrates women scientists in the Americas 2UTSW molecular biologist Olson wins March of Dimes developmental biology prize 2Specialised germanium surface as universal protein adapter 2Specialised germanium surface as universal protein adapter 3
(Date:9/16/2014)... Norris, TN (PRWEB) September 16, 2014 ... several new initiatives to position themselves for ... capabilities for labeling and encoding, Pharma Packaging ... adding new hardware and software and new ... on current Good Manufacturing Practices (cGMP), Pharma ...
(Date:9/16/2014)... ORLEANS , Sept. 16, 2014 In ... Austin, Texas -based cybersecurity company focused on authentication ... ONE, will support the ability to generate a OTP ... As a pioneer of user-based RFID authentication, 2FA,s ... for physical access, for many years. RFID authentication is ...
(Date:9/15/2014)... 2014   Global Science & Technology, Inc. ... and services for satellite and weather systems, was ... Services (OASIS) from the General Services Administration (GSA) ... provide the government best-value solutions for complex professional ... in Pool 4. The OASIS SB award has ...
(Date:9/15/2014)... patient has sepsis, a life-threatening condition in which bacteria ... too fast for antibiotics to help. A new device ... team at Harvard,s Wyss Institute for Biologically Inspired Engineering ... , "Even with the best current treatments, sepsis patients ... percent of the time," said Mike Super, Ph.D., Senior ...
Breaking Biology Technology:Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 22FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4
... Enterprise level ... bank. , ... 2009 -- PacsDrive, LLC. ( www.pacsdrive.com ), a medical imaging software company, announced ... and medium sized health care providers to securely archive medical imaging in compliance with HIPAA ...
... , HUNTINGTON BEACH, California and ... diagnostics, announced today that,Palmetto GBA, California,s Part B Medicare administrator, ... Agendia,s,FDA-cleared breast cancer recurrence test, which has been reimbursed by,payors ... United States can now submit claims for the,MammaPrint test directly ...
... , ATLANTA, Dec. 1 GeoVax Labs, ... biopharmaceutical company developing human vaccines for diseases caused by HIV-1 ... support for World AIDS Day. , "Today is the 21st ... have lost their fight with the HIV/AIDS pandemic, we remain ...
Cached Biology Technology:PacsDrive Announces Low Cost Medical Imaging Storage Service, Seeks to Alter Status Quo in Health Care IT 2Medicare Administrator Establishes Reimbursement Coding Policy for Agendia's Breast Cancer Recurrence Test MammaPrint(R) 2GeoVax Labs, Inc. Celebrates 21st World AIDS Day With Continued Clinical Trial Progress 2GeoVax Labs, Inc. Celebrates 21st World AIDS Day With Continued Clinical Trial Progress 3GeoVax Labs, Inc. Celebrates 21st World AIDS Day With Continued Clinical Trial Progress 4GeoVax Labs, Inc. Celebrates 21st World AIDS Day With Continued Clinical Trial Progress 5GeoVax Labs, Inc. Celebrates 21st World AIDS Day With Continued Clinical Trial Progress 6
Request Info...
Kit containing positive control DNA all parts of the HIV-1 genome, HIV-1 negative control DNA, Primers SK38, SK39, SK19...
Contains 0.2 g/L EDTA4Na in phosphate-buffered saline....
Immunochemistry 1 & 2...
Biology Products: