Navigation Links
Findings point to potential treatment for virus causing childhood illnesses
Date:1/29/2014

WEST LAFAYETTE, Ind. - Researchers have discovered a potential treatment for a viral infection that causes potentially fatal brain swelling and paralysis in children. The findings also point to possible treatments for related viruses including those that cause "common cold" symptoms.

The virus, called enterovirus 71 (EV71), causes yearly outbreaks of hand, foot, and mouth disease in Southeast Asian countries including China and Malaysia. Some of the infected children develop encephalitis that can be fatal or result in permanent brain damage. There are no anti-EV71therapeutic agents available.

The researchers prepared antibodies by immunizing mice with immature EV71 particles. Antibodies generated by this immunization induced a change in the mature EV71 virus, rendering it non-infectious by causing the virus particles to lose their genome.

The findings reveal a potential treatment mechanism, demonstrating that the antibody, called E18, has potential as an anti-EV71 therapy, said Michael G. Rossmann, Purdue's Hanley Distinguished Professor of Biological Sciences.

Findings are being reported this week in Proceedings of the National Academy of Sciences. The paper was authored by Purdue postdoctoral research associate Pavel Plevka; Pei-Yin Lim, a researcher from Sentinext Therapeutics in Penang, Malaysia; Purdue research scientist Rushika Perera; Jane Cardosa, a researcher at Sentinext and MAB Explorations in Malaysia; Purdue graduate student Ampa Suksatu; Richard J. Kuhn, a professor and head of Purdue's Department of Biological Sciences; and Rossmann.

EV71 belongs to a family of viruses called picornaviruses, pathogens that cause diseases including common-cold-like illnesses and poliomyelitis in people and chronic infections in livestock.

"The antibody-mediated virus neutralization by the induction of genome release has not been previously demonstrated," Rossmann said. "These results indicate that antibodies with genome-release activity could also be produced for other picornaviruses by immunization with immature particles. The approach could be used to prepare antibodies with similar properties against related viruses that include significant human pathogens."

Researchers observed and documented the loss of genome using two laboratory techniques: cryoelectron microscopy and a fluorescent SYBR Green dye assay.

Hand, foot and mouth disease, an infection most common among young children, sometimes arises in a daycare setting. Of the 427,278 cases of the disease recorded in China between January and May 2010, 5,454 cases were classified as severe, with 260 deaths, according to the World Health Organization.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Related biology news :

1. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
2. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
3. New findings on protein misfolding
4. New findings on gene regulation and bone development
5. Verinata Health Announces New Findings At The American Society Of Human Genetics
6. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
7. The findings between DNMs and autism provides global view of mutability on human diseases
8. New findings in the search for genetic clues to insulin production
9. ACMG releases report on incidental findings in clinical exome and genome sequencing
10. Findings to help in design of drugs against virus causing childhood illnesses
11. Surprising findings on hydrogen production in green algae
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Findings point to potential treatment for virus causing childhood illnesses
(Date:12/6/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, and the ... five (5) year funding commitment by Securus to ... rehabilitation and reentry support to more inmates and ... 2004, the Prison Entrepreneurship Program (PEP) is an ...
(Date:11/30/2016)... -- higi SH llc (higi) announced today the launch ... industry thought-leaders and celebrity influencers looking to encourage, ... steps to live healthier, more active lives. ... built the largest self-screening health station network in ... have conducted over 185 million biometric screenings.  The ...
(Date:11/24/2016)... -- Cercacor today introduced Ember TM Sport Premium ... measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion Index, ... approximately 30 seconds. Smaller than a smartphone, using only ... key data about their bodies to help monitor these ... Hemoglobin carries oxygen to muscles. When hemoglobin and ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... 2016 AskLinkerReports.com has published a report ... Amyloglucosidase Industry 2016 Market Research Report. From a basic outline ... overview are all covered in the report. This report projects ... analysis of the Amyloglucosidase industry. ... , , ...
(Date:12/8/2016)... ... December 08, 2016 , ... Opal Kelly, a ... device-to-computer interconnect using USB or PCI Express, announced the FOMD-ACV-A4, the company's first ... a small, thin, SODIMM-style module that fits a standard 204-pin SODIMM socket for ...
(Date:12/8/2016)... (PRWEB) , ... December 08, ... ... announces the commercial launch of flexible packaging for their exceptionally efficient human ... bag system extends RoosterBio’s portfolio of bioprocess media products engineered to radically ...
(Date:12/8/2016)... 8, 2016  HedgePath Pharmaceuticals, Inc. (OTCQX: HPPI), ... and plans to commercialize innovative therapeutics for patients ... stock were approved for trading on the OTCQX ... the OTCQX, effective today, under the ticker symbol ... market, companies must meet high financial standards, follow ...
Breaking Biology Technology: