Navigation Links
Findings may help keep pancreatic disease off the menu
Date:4/7/2011

WASHINGTON, April 7, 2011 Timing is everything. That's especially true when it comes to the activation of enzymes created by the pancreas to break down food. When the timing is right, those enzymes are activated only when they reach the gut, where they get to work releasing and distributing nutrients that we need to survive. If the timing is wrong and the enzymes are activated too soon, they break down the pancreas itself, which is painful and sometimes fatal.

Fortunately, most of the time the body is a master timekeeper and has a game plan for what to do if a signaling misfire activates those enzymes too soon. But sometimes even those natural defense mechanisms aren't enough to thwart pancreatitis, making the pursuit of a better understanding of the enzymes' behavior a high priority for patients and physicians.

On Wednesday, April 13, an international research team determined to figure out and eventually manipulate the activation of such enzymes will present an important new finding at the Experimental Biology 2011 meeting in Washington, D.C.

"Acute pancreatitis is the most frequent disease of the pancreas, diabetes is the most prevalent chronic disease of the pancreas and pancreatic cancer is one of the most devastating cancers. Our finding could in the future arm us to better battle or to prevent these serious diseases," explains Mara I. Vaccaro, who oversaw the team's work and who will give a talk about their finding at 10:25 a.m. in Room 207A of the Walter E. Washington Convention Center.

Writing in a Journal of Biological Chemistry "Paper of the Week" last month, Vaccaro's team identified for the first time a cellular process that the pancreas uses to selectively detect and degrade activated enzymes before they can digest the organ, avoiding the progression of disease.

The research team, which included participants from the University of Buenos Aires, the National Institute of Health and Medical Research in
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Saint Louis University findings: Dont pitch stockpiled avian flu vaccine
2. New findings in Indias Bt cotton controversy: Good for the field, bad for the farm?
3. New findings provide cost, benefit data for Florida citrus industry
4. Findings on pollution damage to human airways could yield new therapies
5. 23andMe presents top 10 most interesting genetic findings of 2010
6. Findings suggest new cause, possible treatment for multiple sclerosis
7. Biomedical and health professionals converge in D.C. to absorb new findings in science of informatics
8. Unexpected findings of lead exposure may lead to treating blindness
9. Gynecologist disputes findings
10. New findings pull back curtain on relationship between iron and Alzheimers disease
11. MBL scientists reveal findings of World Ocean Microbe Census
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... its efforts to make it easier to detect ... supply chain. Today the agency started ... marking. The capability will validate the authenticity of ... supply chain. The new quality control measures will ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ... beliefs about the condition and the best ways to treat ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... were dubious in the early 1980s when they stumbled on ... only were they not supposed to be there, but they ... from proteins, effectively switching them on and off. The ... and off -- and thus determining their actions -- fell ...
... St. Louis, Oct.20, 2008 Researchers have shown that self-induced ... activate genes that cause the cells to travel from where ... Scientists have known for two decades or more ... creating splits in both of the two strands. However, the ...
... COLUMBUS, Ohio Reducing the number of deer in ... reptiles, amphibians and insects in that area, new research ... Ohio State University and National Park Service found that ... ways. Out of several species of snakes, salamanders, and ...
Cached Biology News:Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk 2Seemingly suicidal stunt is normal rite of passage for immune cells 2Seemingly suicidal stunt is normal rite of passage for immune cells 3Snakes, salamanders and other creatures thrive in areas with higher deer populations 2Snakes, salamanders and other creatures thrive in areas with higher deer populations 3
(Date:12/19/2014)... Today, TiFiber, Inc. ... facility and future company headquarters in Fort Smith, ... materials that safely and effectively control dangerous microorganisms. ... its historic, strong support for manufacturing, but also ... edge, technology-based companies such as TiFiber. , ...
(Date:12/19/2014)... December 18, 2014 iLab Solutions, the ... appointment of Siri Bryant as the new Director of ... of Core Implementations. These two new leadership positions were ... service by ensuring that iLab continues to meet the ... last four years, iLab has been deployed at over ...
(Date:12/19/2014)...  Decision Resources Group finds that the ... moderately through 2023 as the aging population, increasing adoption ... biomaterials all spur procedure volumes. Growth will be particularly ... and India , where ... for a larger proportion of the population. ...
(Date:12/17/2014)... The Activated Carbon Manufacturing ... why IBISWorld updated its original industry research report. ... an intensified focus on environmental policy. Over the five ... for power plants and a range of other industrial ... Analyst Sarah Kahn, “a range of downstream industrial sectors ...
Breaking Biology Technology:Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3
... , May 27 Medivation, ... of its public offering of 2,750,000 shares of its common ... The company expects to complete the sale of these shares ... the underwriters a 30-day option to purchase 412,500 additional shares ...
... (Nasdaq: BLUD ), a global leader ... transfusion industry, announced today that it has signed ... one of the largest regional hospital laboratory integrated ... in Illinois and Indiana. Under the agreement, Alverno ...
... - Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI ... partner, Boston Scientific Corporation (NYSE: BSX ... and Drug Administration (FDA) to market its TAXUS(R) ... deliverable, next-generation drug-eluting stent (DES) specifically designed for ...
Cached Biology Technology:Medivation Announces Pricing of Public Offering 2Immucor and Alverno Clinical Laboratories Sign Five-Year Automation Agreement 2Angiotech Pharmaceuticals announces FDA approval of next-generation TAXUS(R) Liberte(R) Atom(TM) Stent system 2Angiotech Pharmaceuticals announces FDA approval of next-generation TAXUS(R) Liberte(R) Atom(TM) Stent system 3Angiotech Pharmaceuticals announces FDA approval of next-generation TAXUS(R) Liberte(R) Atom(TM) Stent system 4Angiotech Pharmaceuticals announces FDA approval of next-generation TAXUS(R) Liberte(R) Atom(TM) Stent system 5
Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: 4C...
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... microcapillary flow cytometry accessible to anyone in ... appreciate the latest addition to Guavas on-demand ... surprising affordable, and very compact for higher ... features as absolute cell counts, 6 parameters ...
...
Biology Products: