Navigation Links
Finding triggers of birth defects in an embryo heart
Date:10/30/2012

Researchers at Case Western Reserve University have found a way to create three-dimensional maps of the stress that circulating blood places on the developing heart in an animal model a key to understanding triggers of heart defects.

The team has begun testing the technology to uncover how alcohol, drugs and other factors set off events that result in defects found in newborn humans.

Passing blood cells drag on the endothelial cells that line the growing heart, a phenomenon called shear stress, which has been linked to changes in gene expression that results in defects, most often in the valves. But precisely how they're connected is unclear.

"Alcohol exposure may affect shear stress by modulating the heart rate, but it may also involve vigor and/or timing of the contraction," said Andrew Rollins, associate professor of biomedical engineering and senior author of the new study. "Now that we have the tool, we can start to figure that out."

"We're analyzing early and late development of the heart and trying to make the connections that result in valve dysfunction," said Lindsy M. Peterson, a PhD student in Rollins' lab and lead author. Their work is published in the current online issue of the Optical Society of America's journal Biomedical Optics Express.

The pair teamed with research assistant professor Michael W. Jenkins; senior research associate Shi Gu; Lee Barwick, an undergraduate researcher now at Brigham Young University; and Michiko Watanabe, a professor of pediatrics at Case Western Reserve School of Medicine.

To look at the structure of the developing heart and blood flow, the researchers modified a technology called Doppler optical coherence tomography. Called OCT for short, they shine an infrared laser on the heart.

The reflections measured at various depths are used to create a three-dimensional image in much the same manner submariners use sonar to picture their surroundings i
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. One click away: Finding data on Floridas endangered species just got easier
2. New findings on protein misfolding
3. Finding new research frontiers in a single cell
4. Team discovers reason that male moths can keep finding females
5. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
6. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
7. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
8. UMD finding may hold key to Gaia hypothesis
9. A single stem cell mutation triggers fibroid tumors
10. Researchers identify genetic basis of cardiac, craniofacial birth defects
11. Obese moms give birth to heart healthier kids following bariatric surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... -- Growing need for data security coupled ... to drive India biometrics market   ... " India Biometrics Market Forecast & Opportunities, 2020 ", biometrics ... grow at a CAGR of over 35% during 2015 - ... extensive use of biometric technology in the government sector. Ongoing ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Saudi Arabia Biomedical Sensors Market - Growth, ... The Saudi Arabia Biomedical Sensors market ... CAGR of 3.64% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:8/28/2015)... , August 28, 2015 ... and Training Market by Assessment Type (Pen & Paper ... Brain Training, Corporate Learning, Academic Research), Vertical and Region ... Assessment and Training Market to grow from USD 2.4 ... at a Compound Annual Growth Rate (CAGR) of 25.6% ...
Breaking Biology News(10 mins):India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4
... Research expresses its congratulations to and appreciation of ... 2010 Leadership in Personalized Medicine Award from the Personalized ... distinguished member of the AACR for more than 20 ... the Harvard Personalized Medicine Conference on Nov. 17. According ...
... burn fossil fuels remain the main source of electricity ... to remove sulfur compounds from their flue gases, which ... researchers in India have devised a way to convert ... value-added products. They describe details in the International ...
... of a fruit fly embryo, which was taken by ... beaten-off stiff competition from hundreds of entries to win ... biodiversity. Samantha Warrington, a postgraduate student from the ... in the ,close-up category, at the Society of Biology,s ...
Cached Biology News:AACR congratulates William S. Dalton on 2010 Leadership in Personalized Medicine Award 2Snap of fruit fly embryo wins scientific photo competition 2
(Date:8/31/2015)... CA (PRWEB) , ... August 31, 2015 , ... There’s ... Minerva is the first commercially available new FDA approved system in the ... Success rate of 92%, the high Amenorrhea (zero bleeding) rate of 66%, the high ...
(Date:8/30/2015)... , August 31, 2015 , ... Frau   für chirurgische   Behandlung     ... 7-90   werden für eine   verheerende   Geburtsverletzung ... behandeln und die Anzahl ausgebildeter Chirurgen in Kenia bis ... gab heute bekannt, dass  Action on Fistula  seit ihrem ...
(Date:8/28/2015)... -- According to a new market research ... Thawing Equipment, Alarms), by Biospecimen (Human Tissue, Stem Cells, ... - Global Forecast to 2020", published by MarketsandMarkets, the ... Million by 2020 from USD 2,150.48 Million in 2015, ... 2020. Browse 74 Tables and 95 ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... Chuck Gardner, has organized and will present a session on chemical spectroscopic imaging ... This conference and exposition is Asia’s largest analytical and scientific instruments show which ...
Breaking Biology Technology:U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3
... Rhythm announced today the results of a Phase 1b ... for the treatment of diabetic gastroparesis. The trial demonstrated ... diabetic gastroparesis. The findings were presented at the Digestive ... The Phase 1b clinical trial was a randomized, double-blind, ...
... To become better healers, tissue engineering need a timely and ... already are or can become the tissue they need to ... that the stiffness, viscosity, and other mechanical properties of adult ... predict whether they will turn into bone, cartilage, or fat. ...
... New York, May 21, 2012 Elsevier,s Computers & ... on 3D Object Retrieval which will incorporate the Collage Authoring ... place winner of the 2011 Executable Paper Grand Challenge. The ... Eurographics 2012 on May 13, during the 3DOR Workshop. ...
Cached Biology Technology:Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Diabetic Gastroparesis 2Physical properties predict stem cell outcome 2Physical properties predict stem cell outcome 3
... detector is an optical unit that can ... or Dyad Disciple gradient-capable thermal cycler (purchased ... photonics shuttle that contains four LEDs for ... nm, 620-650 nm) and two filtered photodiodes ...
... sensitive laser confocal systems designed for rapid ... that meet your expectations, differentiating between a ... the signal on the bottom as well ... for increased sensitivity. Results with VersArray ChipReader ...
... perform 96 assays on four slides. The ... slides with 96 (6mm x 7mm) individual ... expression, or screening analysis studies. Unlike other ... gasket, eliminating the presence of contaminating adhesives. ...
... with sequence siTrio siRNA --- a ... target gene of interestis our most popular product. ... 75% knockdown of your target gene when used ... and confirmation of optimal transfection with one of ...
Biology Products: