Navigation Links
Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
Date:8/31/2009

A research report featured on the cover of the September 2009 print issue of The FASEB Journal (http://www.fasebj.org) describes how Australian scientists developed a new gene therapy vector that uses the same machinery that viruses use to transport their cargo into our cells. As a result of this achievement, therapeutic DNA can be transferred to a cell's nucleus far more efficiently than in the past, raising hopes for more effective treatment of genetic disorders and some types of cancers.

"Through the use of proteins that mimic key functions of viruses for the packaging and transport of therapeutic DNA, we hope to improve the efficiency, and above all, the specificity of human gene therapy," said David Jans, from the Nuclear Signaling Laboratory at Monash University in Victoria, Australia and one of the researchers involved in the work. "Following the creation of efficient, specific and safe DNA delivery vectors, the challenges in human gene therapy will be able to move on from questions of delivery to actual clinical application."

In short, a gene therapy vector is used to deliver a therapeutic gene or a portion of DNA into a cell nucleus similar to how a syringe is used to inject medicines. To create the new gene therapy vector, Jans and colleagues used pieces of different genes to create a protein called a "modular DNA carrier," which can be produced by bacteria. This protein carries therapeutic DNA and delivers it to a cell's nucleus, where it reprograms a cell to function properly. In the laboratory, these carrier proteins were combined with therapeutic DNA and attached to cell membrane receptors and the nuclear import machinery of target cells. In turn, the packaged DNA moved into the cell through the cytoplasm and into the nucleus.

"Effective gene therapy is clearly the best way to treat heritable diseases. It's also an approach to other diseases where the environment or infection messes up our genes." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The Australians have worked out how viruses identify our nuclear ZIP-code, and have delivered therapeutic genes to the same address. This work opens up a new era of pharmaceutical development."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Finding the constant in bacterial communication
2. Gene expression findings a step toward better classification and treatment of juvenile arthritis
3. Genetic finding could lead to targeted therapy for neuroblastoma
4. USC researchers present diabetes findings at American Diabetes Association Scientific Sessions
5. SRI International announces findings from new upper atmospheric radar system for scientific research
6. Proteomics: Finding the key ingredients of disease
7. Findings uncover new details about mysterious virus
8. New findings in taste and smell
9. FANTOM findings boost for biologists
10. Findings show insulin -- not genes -- linked to obesity
11. International climate change researchers meet, review latest findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2016)... 22, 2016 According to the new market research ... Face, Vein, Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and ... the market is expected to grow from USD 10.74 Billion in 2015 ... between 2016 and 2022. Continue Reading ... ...
(Date:11/21/2016)... 21, 2016   Neurotechnology , a provider ... today announced that the MegaMatcher On Card fingerprint ... for the NIST Minutiae Interoperability Exchange (MINEX) ... mandatory steps of the evaluation protocol. ... test of fingerprint templates used to establish compliance ...
(Date:11/17/2016)... , Nov. 17, 2016 Global Market Watch: ... Biobanks (Disease-Based Banks, Population-Based Banks and Academics) market is to ... for Private Biobanks shows the highest Compounded Annual Growth Rate ... region during the analysis period 2014-2020. North ... of 9.95% followed by Europe at ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... AUSTIN, Texas , Dec. 7, 2016 /PRNewswire/ ... development of revolutionary immunogene therapy treatments, today announced ... healthcare practice within a leading strategic communications and ... strategic communications program. The program will combine investor ... the objective of raising the profile of Genprex ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... recovery solutions for industrial facilities, today announced that one of the nation’s fastest ... use Cambrian’s novel water-energy purchase agreement (WEPA). Under the WEPA, a first for ...
(Date:12/7/2016)... Massachusetts (PRWEB) , ... December 07, 2016 , ... Kara Dwyer Dodge grew up hearing ... Dwyer, a third-generation fisherman in Scituate, Mass., found a sea turtle entangled in the lines ... where the turtle became a minor sensation because no one could remember ever seeing one ...
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... on December 1, 2016 asking the Federal Drug Administration (FDA) to consider OA ... of OA, OARSI is concerned about the growing population of OA patients, many ...
Breaking Biology Technology: