Navigation Links
Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
Date:8/31/2009

A research report featured on the cover of the September 2009 print issue of The FASEB Journal (http://www.fasebj.org) describes how Australian scientists developed a new gene therapy vector that uses the same machinery that viruses use to transport their cargo into our cells. As a result of this achievement, therapeutic DNA can be transferred to a cell's nucleus far more efficiently than in the past, raising hopes for more effective treatment of genetic disorders and some types of cancers.

"Through the use of proteins that mimic key functions of viruses for the packaging and transport of therapeutic DNA, we hope to improve the efficiency, and above all, the specificity of human gene therapy," said David Jans, from the Nuclear Signaling Laboratory at Monash University in Victoria, Australia and one of the researchers involved in the work. "Following the creation of efficient, specific and safe DNA delivery vectors, the challenges in human gene therapy will be able to move on from questions of delivery to actual clinical application."

In short, a gene therapy vector is used to deliver a therapeutic gene or a portion of DNA into a cell nucleus similar to how a syringe is used to inject medicines. To create the new gene therapy vector, Jans and colleagues used pieces of different genes to create a protein called a "modular DNA carrier," which can be produced by bacteria. This protein carries therapeutic DNA and delivers it to a cell's nucleus, where it reprograms a cell to function properly. In the laboratory, these carrier proteins were combined with therapeutic DNA and attached to cell membrane receptors and the nuclear import machinery of target cells. In turn, the packaged DNA moved into the cell through the cytoplasm and into the nucleus.

"Effective gene therapy is clearly the best way to treat heritable diseases. It's also an approach to other diseases where the environment or infectio
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Finding the constant in bacterial communication
2. Gene expression findings a step toward better classification and treatment of juvenile arthritis
3. Genetic finding could lead to targeted therapy for neuroblastoma
4. USC researchers present diabetes findings at American Diabetes Association Scientific Sessions
5. SRI International announces findings from new upper atmospheric radar system for scientific research
6. Proteomics: Finding the key ingredients of disease
7. Findings uncover new details about mysterious virus
8. New findings in taste and smell
9. FANTOM findings boost for biologists
10. Findings show insulin -- not genes -- linked to obesity
11. International climate change researchers meet, review latest findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... 2014)The link between autism and disrupted brain development ... the disease, and is largely unknown. However, thanks ... Initiative (SFARI), George Washington University (GW) researcher Anthony-Samuel ... integrative and in-depth answers to these key questions ... LaMantia, professor of pharmacology and physiology at the ...
(Date:7/25/2014)... increasingly consume the healthcare community and remain ... , To address the worldwide crisis of ... countries, global leaders in diabetes, epidemiology and ... prevention and development of diverse intervention programs ... , This book on "Global Health Perspectives ...
(Date:7/25/2014)... tractography (DTT), which is derived from diffusion tensor ... motor tracts, such as the corticospinal tract, the ... The corticospinal tract is known to be a ... human brain. Several studies have reported on injury ... addition, some studies have demonstrated recovery of a ...
Breaking Biology News(10 mins):GW researcher receives grant to answer the how and why of autism during development 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... less than two weeks, Amanda Cobbs-Russell, a junior majoring in ... the adventure of a lifetime, requiring her to push herself ... of only five people two Americans and three Canadians ... to hike, eat, and sleep among sweeping glaciers, polar ice ...
... American Society for Microbiology (ASM) ICAAC Young Investigator Award ... College London. Sponsored by the ASM, this award ... and infectious diseases. Dr. Grndling,s initial work focused ... the membrane and how S monomers interact. She constructed ...
... state of upheaval, it is expected that they might take refuge ... milkshake? Not so, says Stacy L. Wood, Associate ... South Carolina. In fact, in a study to be published ... when people are in a state of upheaval, they,re more likely ...
Cached Biology News:UC Riverside student is 1 of only 5 persons selected for challenging Arctic expedition 2UC Riverside student is 1 of only 5 persons selected for challenging Arctic expedition 3
(Date:7/24/2014)... OAK RIDGE, Tenn., July 24, 2014 -- A novel ... at the Department of Energy,s Oak Ridge National Laboratory ... known for its unusual physical and electrochemical properties. ... examined how oxygen affects the surface of a perovskite ... electronic behavior. The new avenue to understand surface behavior ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... 2014 Research and Markets has ... Market 2014-2018" report to their offering.  ... is the in vitro growth of plant or animal ... and biopharmaceutical production. Cell culture is a crucial step ... and cell culture consumables are necessary for the in ...
(Date:7/24/2014)... Three companies from the angelMD network were ... Competition. Out of 700 competition entrants, Chiron Health, Litesprite, ... round. In this round twenty teams are invited to ... mentoring from thought-leaders and medical entrepreneurs from all over ... commitment to the Livestrong vision around the Big C ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Nano-sized chip 'sniffs out' explosives far better than trained dogs 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... ANTONIO, March 30 BioMedical Enterprises, Inc. (BME), a ... development of orthopaedic memory metal implants, announced today that ... President, Sales and Marketing. BME specializes in nitinol ... bone ends together to promote bone union. The ...
... DIEGO, CA, March 30, 2009 Senomyx, Inc. (Nasdaq: ... using proprietary technologies to discover and develop novel flavor ... announced today the extension of the collaborative research phase ... Campbell Soup Company, a global manufacturer and marketer of ...
... final study data to FDA for cervical cancer vaccinePHILADELPHIA ... GSK ) today provided the following update regarding its ... for approval of CERVARIX(R), its vaccine to prevent cervical ... 16 and 18.GSK has submitted final data from its ...
Cached Biology Technology:BioMedical Enterprises, Inc. (BME) Announces the Appointment of Keith M. Peeples as Vice President, Sales and Marketing 2SENOMYX ANNOUNCES EXTENSION OF ITS COLLABORATION WITH CAMPBELL SOUP COMPANY 2SENOMYX ANNOUNCES EXTENSION OF ITS COLLABORATION WITH CAMPBELL SOUP COMPANY 3CERVARIX(R) U.S. Regulatory Update 2CERVARIX(R) U.S. Regulatory Update 3
... NaCl, 20mM MOPS, pH 7.5, 60mM ... EGTA, 10 Properites: For selective in ... chromatography, divalent cation activation plus trypsin ... Assurance: routinely evaluated by dephosphorylation of ...
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
HNF-1 Purified Anti-Mouse, Anti-Rat, Anti-Rabbit, Anti-Human clone 2, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Recombinant Porcine IL-1 alpha/IL-1F1, CF...
Biology Products: