Navigation Links
Finding a few foes among billions of cellular friends
Date:2/26/2014

Beating cancer is all about early detection, and new research from the University of South Carolina is another step forward in catching the disease early. A team of chemists is reporting a new way to detect just a handful of lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy cells.

The researchers have constructed an ultrasensitive nanoprobe that can electrochemically sense as few as four circulating tumor cells, and it doesn't require any enzymes to produce a detectable signal.

"That makes it a very robust system," says Hui Wang, a chemist in the university's College of Arts and Sciences who led the research team with South Carolina colleague Qian Wang and Jun-Jie Zhu of Nanjing University. "We show that it's much less sensitive to pH and temperature than the natural enzyme horseradish peroxidase, a traditional means of enhancing sensitivity."

Cancer can metastasize by releasing tumor cells that are capable of spreading the disease to new parts of the body. But the circulating cells also represent a golden opportunity for modern medicine: detecting them in a patient is a telltale sign of a tumor.

They're tough to find, though. In a billion blood cells, there might be just one circulating tumor cell that could trip an alarm.

The enzyme-free detection system is based on the electrochemical properties of Fe3O4 nanoparticles, which since 2007 have been known to mimic the peroxide-reducing capacity of horseradish peroxidase. Wang's team was surprised to find that the nanoparticles could also catalyze the electrochemical reduction of small dye molecules, such as thionine, even in the absence of peroxide.

Wang and his team recently reported in the Journal of the American Chemical Society how they decorated Fe3O4 beads with bimetallic nanocages to create a hybrid electrocatalyst. Circulating tumor cells that were trapped onto an electrode surface with cell-ta
'/>"/>

Contact: Steven Powell
spowell2@mailbox.sc.edu
803-777-1923
University of South Carolina
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Finding common ground fosters understanding of climate change
2. New finding points to potential options for attacking stem cells in triple-negative breast cancer
3. Cell division finding could boost understanding of cancer
4. Finding Israels first camels
5. Findings point to potential treatment for virus causing childhood illnesses
6. Findings bolster fibers role in colon health
7. New breast cancer stem cell findings explain how cancer spreads
8. Spinal cord findings could help explain origins of limb control
9. Finding about classic suppressor of immunity points toward new therapies for bad infections
10. In surprise finding, blood clots absorb bacterial toxin
11. New finding shows that mother sharks home to their birthplace to give birth, like salmon and sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding a few foes among billions of cellular friends
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences International ... has released a new series of digital telemetry ... toxicology researchers. M series, part of the PhysioTel™ ... the best possible physiologic data when incorporating functional ...
(Date:12/10/2014)... Dec. 9, 2014  Wake Forest Baptist Medical Center today announced ... of Medicine. Funding for this $50 million capital project is ... launched next summer. The medical education building ... Tobacco Company complex, adjacent to 525@vine in Wake Forest Innovation ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... malnutrition, created by researchers at Penn State, will aid ... treatment. Up to 50 percent of patients in ... according to Gordon Jensen, professor and head of nutritional ... in the clinical community on how to best make ...
... with death, the underworld and eternity. Indeed, the family to ... a new study of their evolution affords a unique insight ... During the geological era known as the Mesozoic, the continental ... Pangea. Pangea began to break up about 150 million years ...
... Michigan State University have shown a prebiotic may help ... and reduce inflammation, greatly decreasing the risk of colon ... food for the trillions of tiny bacteria living in ... of the "good" bacteria. The evolution of prebiotic supplements ...
Cached Biology News:Researchers unveil new assessment for diagnosing malnutrition 2Earth history and evolution 2Researchers show prebiotic can reduce severity of colitis 2
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero ... for Biomedical Research abre hoy su llamada a nominaciones ... cuya investigación científica ha hecho, o tiene el potencial ... salud humana. Las nominaciones se aceptarán hasta el 15 ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by ... Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, End ... to 2019” provides a detailed overview of the ... and strategies impacting the preparative and process chromatography ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... 23, 2010) Pity the female fruit fly. Being a looker ... proposal, you have to act like a girl, even smell like ... Like most animals, fruit flies must distinguish between a ... suspects he,s encountered a female, he,ll court; when he senses the ...
... short, powerful light pulses on a chip an ... replace the copper wires that carry information between chips ... engineers recently developed the first ultra compact, low power ... in the scientific literature. Details appeared online in the ...
... Nottingham have made a major breakthrough that could help shape ... that 3-D molecular structures can be built on a surface. ... the development of new nano devices such as cutting-edge optical ... paper published in the prestigious journal Nature Chemistry , ...
Cached Biology Technology:Battle of the sexes, fruit-fly style 2Short, on-chip light pulses will enable ultrafast data transfer within computers 2Short, on-chip light pulses will enable ultrafast data transfer within computers 3Short, on-chip light pulses will enable ultrafast data transfer within computers 4World-first to provide building blocks for new nano devices 2
Black Polypropylene 384 Round Well Plate 70/Box...
... to Peroxiredoxin 1 Peroxiredoxin (Prx) ... mammalian members have been known to ... apoptosis. Many isoforms (about 50 proteins), ... acid sequence homology, particularly amino-terminal region ...
... • Heat activated ,• ... room temperature ,• Excellent specificity allows ... and secondary structures ,• Leaves an ... chemically modified form of GeneChoice DNA Polymerase ...
... Rabbit polyclonal to beta Synuclein Synucleins ... neural tissue and in certain tumors. The ... beta synuclein, and gamma synuclein. The alpha ... in brain tissue, where they are seen ...
Biology Products: