Navigation Links
Finding a few foes among billions of cellular friends
Date:2/26/2014

Beating cancer is all about early detection, and new research from the University of South Carolina is another step forward in catching the disease early. A team of chemists is reporting a new way to detect just a handful of lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy cells.

The researchers have constructed an ultrasensitive nanoprobe that can electrochemically sense as few as four circulating tumor cells, and it doesn't require any enzymes to produce a detectable signal.

"That makes it a very robust system," says Hui Wang, a chemist in the university's College of Arts and Sciences who led the research team with South Carolina colleague Qian Wang and Jun-Jie Zhu of Nanjing University. "We show that it's much less sensitive to pH and temperature than the natural enzyme horseradish peroxidase, a traditional means of enhancing sensitivity."

Cancer can metastasize by releasing tumor cells that are capable of spreading the disease to new parts of the body. But the circulating cells also represent a golden opportunity for modern medicine: detecting them in a patient is a telltale sign of a tumor.

They're tough to find, though. In a billion blood cells, there might be just one circulating tumor cell that could trip an alarm.

The enzyme-free detection system is based on the electrochemical properties of Fe3O4 nanoparticles, which since 2007 have been known to mimic the peroxide-reducing capacity of horseradish peroxidase. Wang's team was surprised to find that the nanoparticles could also catalyze the electrochemical reduction of small dye molecules, such as thionine, even in the absence of peroxide.

Wang and his team recently reported in the Journal of the American Chemical Society how they decorated Fe3O4 beads with bimetallic nanocages to create a hybrid electrocatalyst. Circulating tumor cells that were trapped onto an electrode surface with cell-ta
'/>"/>

Contact: Steven Powell
spowell2@mailbox.sc.edu
803-777-1923
University of South Carolina
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Finding common ground fosters understanding of climate change
2. New finding points to potential options for attacking stem cells in triple-negative breast cancer
3. Cell division finding could boost understanding of cancer
4. Finding Israels first camels
5. Findings point to potential treatment for virus causing childhood illnesses
6. Findings bolster fibers role in colon health
7. New breast cancer stem cell findings explain how cancer spreads
8. Spinal cord findings could help explain origins of limb control
9. Finding about classic suppressor of immunity points toward new therapies for bad infections
10. In surprise finding, blood clots absorb bacterial toxin
11. New finding shows that mother sharks home to their birthplace to give birth, like salmon and sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding a few foes among billions of cellular friends
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "Global Facial Recognition ... http://photos.prnewswire.com/prnh/20130307/600769 ... identification of individuals. Facial recognition system measures the ... nose, jaw edges, mouth, and the distance between ...
(Date:12/11/2014)... ST. PAUL, Minn. , Dec. 10, 2014 ... in wireless physiologic monitoring, has released a new ... changing needs of preclinical toxicology researchers. M series, ... to help toxicologists collect the best possible physiologic ... studies. Adding functional endpoints to toxicology ...
(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... of spinal cord injuries among senior citizens (age 70 and ... as compared with younger spinal cord injury patients, researchers at ... Center of the Delaware Valley recently reported. , As the ... 20 percent of its population will be older than age ...
... Systematic Review of the use of electronic mosquito repellents (EMRs) ... therefore say that there is no reason for recommending their ... to do more research with the devices. , Malaria is ... mosquito. Manufacturers of electronic mosquito repellents (EMRs) claim that the ...
... and zanamivir, are highly effective when given as ... the influenza virus, according to an analysis of ... Research Center, University of Michigan and University of ... the American Journal of Epidemiology. The analysis also ...
Cached Biology News:Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find 2Antivirals effectively curb influenza virus 2Antivirals effectively curb influenza virus 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... LAVAL, QC, June 4 /PRNewswire-FirstCall/ - Neptune Technologies & ... it has signed an agreement with Bayer Healthcare, LLC ... United States. , "The signing of this agreement with ... business and scientific choice to pursue the more demanding ...
... June 4 Santaris Pharma today announced that,the cancer ... by,Enzon Pharmaceuticals and Santaris Pharma A/S - was well ... treated cancer patients with,advanced malignancies. EZN-2968 is being evaluated ... which was presented at the 2009 American,Society of Clinical ...
... OPTR ) today announced that the Company will present at the following investor ... 8th Annual Needham Life Sciences Conference on Wednesday, June 10, ... New York City. , Jefferies, 3rd Annual ... the Mandarin Oriental Hotel in New York City. , ...
Cached Biology Technology:Neptune Products to be commercialized by BAYER HealthCare 2Neptune Products to be commercialized by BAYER HealthCare 3LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit 2LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit 3Optimer Pharmaceuticals to Present at June 2009 Investor Conferences 2
Human FADD Affinity Purified Polyclonal Ab...
Human VEGF R3/Flt-4 Phycoerythrin MAb (Clone 54733)...
Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human beta IG-H3 MAb (Clone 348506) Keywords: BIGH3, betaIG-H3 Protein Family: Extracellular Matrix Molecules...
Biology Products: