Navigation Links
Finding a few foes among billions of cellular friends
Date:2/26/2014

Beating cancer is all about early detection, and new research from the University of South Carolina is another step forward in catching the disease early. A team of chemists is reporting a new way to detect just a handful of lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy cells.

The researchers have constructed an ultrasensitive nanoprobe that can electrochemically sense as few as four circulating tumor cells, and it doesn't require any enzymes to produce a detectable signal.

"That makes it a very robust system," says Hui Wang, a chemist in the university's College of Arts and Sciences who led the research team with South Carolina colleague Qian Wang and Jun-Jie Zhu of Nanjing University. "We show that it's much less sensitive to pH and temperature than the natural enzyme horseradish peroxidase, a traditional means of enhancing sensitivity."

Cancer can metastasize by releasing tumor cells that are capable of spreading the disease to new parts of the body. But the circulating cells also represent a golden opportunity for modern medicine: detecting them in a patient is a telltale sign of a tumor.

They're tough to find, though. In a billion blood cells, there might be just one circulating tumor cell that could trip an alarm.

The enzyme-free detection system is based on the electrochemical properties of Fe3O4 nanoparticles, which since 2007 have been known to mimic the peroxide-reducing capacity of horseradish peroxidase. Wang's team was surprised to find that the nanoparticles could also catalyze the electrochemical reduction of small dye molecules, such as thionine, even in the absence of peroxide.

Wang and his team recently reported in the Journal of the American Chemical Society how they decorated Fe3O4 beads with bimetallic nanocages to create a hybrid electrocatalyst. Circulating tumor cells that were trapped onto an electrode surface with cell-targeting aptamers were detected by cyclic voltammetry of thionine. The system had a wide linear response range and a detection limit down to just a few cells.

There's still a long way to go to get a device into the clinic, but Wang can see the potential of the sturdy inorganic nanoprobes.

"We can actually quantify the biomarkers expressed on cancer cells, and because the expression levels on the cancer cells are quite different from the normal cells, we can actually identify the cancer cells," he says. "Since the sensitivity is really high, if you have low-abundance cancer cells in the body, we should be able to detect them."


'/>"/>

Contact: Steven Powell
spowell2@mailbox.sc.edu
803-777-1923
University of South Carolina
Source:Eurekalert  

Related biology news :

1. Finding common ground fosters understanding of climate change
2. New finding points to potential options for attacking stem cells in triple-negative breast cancer
3. Cell division finding could boost understanding of cancer
4. Finding Israels first camels
5. Findings point to potential treatment for virus causing childhood illnesses
6. Findings bolster fibers role in colon health
7. New breast cancer stem cell findings explain how cancer spreads
8. Spinal cord findings could help explain origins of limb control
9. Finding about classic suppressor of immunity points toward new therapies for bad infections
10. In surprise finding, blood clots absorb bacterial toxin
11. New finding shows that mother sharks home to their birthplace to give birth, like salmon and sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding a few foes among billions of cellular friends
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and ... of osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular ...
(Date:10/10/2017)... Poway, California (PRWEB) , ... October 10, 2017 , ... ... afternoon speaking at his local San Diego Rotary Club. The event ... San Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
(Date:10/9/2017)... Phoenix, Arizona (PRWEB) , ... October 09, 2017 ... ... of Kindred, a four-tiered line of medical marijuana products targeting the needs of ... production and packaging of Kindred takes place in Phoenix, Arizona. , As operators ...
Breaking Biology Technology: