Navigation Links
Final chapter to 60-year-old blood group mystery
Date:4/7/2013

Researchers have uncovered the gene at the root of a human blood group that has remained a mystery for the past 60 years. They showed that a genetic deletion on this gene is responsible for the lack of this blood group in some people.

With the discovery of the gene behind the Vel blood group, medical scientists can now develop a more reliable DNA test to identify people who lack this group. This will reduce the risk of severe, and sometimes life threatening, destruction of the Vel-positive donor red blood cells in patients with antibodies against Vel.

The genetic basis of nearly all 34 blood group systems has been resolved over the past century, but identification of the underlying gene of the Vel blood group has withstood persistent attempts since it was first identified 60 years ago. It is estimated that one in 5000 people are Vel-negative, and routine blood transfusions for patients with antibodies against Vel can lead to kidney failure and even death.

"This is really exciting as it shows how the power of modern genomics technologies can directly benefit patient care," says Professor Willem Ouwehand , who heads one of the NHS Blood and Transplant research teams at both the University of Cambridge and the Wellcome Trust Sanger Institute. "This is also a milestone in blood group genetics and the end of long and astounding journey of discoveries in blood group genetics which started with Landsteiner from Austria and Fisher, Coombs and Morgan from England."

The discovery by the team would not have been possible without the colleagues from the blood transfusion services of Denmark, England and the Netherlands who undertook the Herculean effort of identifying the 65 individuals that lacked the Vel blood group by testing the red blood cells from nearly 350,000 donors with antibodies against Vel.

They then sequenced the coding fraction of the genomes of five donors who lack the Vel group to identify the underlying gene.'/>"/>

Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. WPI Biomedical Technology in final 4 of international business plan contest
2. Researchers attack HIVs final defenses before drug-resistant mutations emerge
3. Dark matter made visible before the final cut
4. Finalists of air pollution sensor challenge announced
5. NYBG press publishes final volume of landmark Intermountain Flora series
6. Sequencing works in clinical setting to help -- finally -- get a diagnosis
7. Planet under Pressure conference, London: Final statement
8. FASEB MARC Travel Awards announced for the 2013 American College of Sports Medicine Northwest Chapter Meeting
9. UTSA physiologist William Cooke named 2013 Lecture Series Speaker by Texas Sports Medicine Chapter
10. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
11. MRI measure of blood flow over atherosclerotic plaque may detect dangerous plaque
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... July 2012, Apple introduced the fingerprint reading feature ... only device of Apple incorporating such a feature, ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... of the "Micro Market Monitor: North America Perimeter ... http://photos.prnewswire.com/prnh/20130307/600769 The ... at a CAGR of 3.6% from 2014 to 2019. ... this market, Canada is expected ...
(Date:12/19/2014)...  23andMe, Inc., the leading personal genetics company, today ... differences in genetic ancestry of individuals from across ... immigrants first arrived more than four hundred years ago, ... as a meeting place for peoples from different continents. ... mixing of peoples with African, European, and American origins ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... , This release is available in ... discovered a mechanism that helps to explain resilience ... work. The new findings, in the reward circuit ... high tech dragnet for compounds that boost the ...
... Researcher in the University of Bristol,s School of Biological Sciences ... as a cue to find coral reefs, but was amazed ... larvae which must quickly find a safe place to ... can do the same thing. The team designed a ...
... For years, researchers have known that resistance exercise training ... another force can be one of the most effective ... But many older people are unable to get the full ... as arthritis that prevent them from lifting enough weight to ...
Cached Biology News:Resilience factor low in depression, protects mice from stress 2Resilience factor low in depression, protects mice from stress 3Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction 2
(Date:12/19/2014)... 19, 2014 Research and Markets ... the "Technology Innovations in Smart Fabrics (Technical ... http://photos.prnewswire.com/prnh/20130307/600769 The ... offers a detailed assessment on technological advancements and ... 1. The Smart Fabrics market ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Ed Bilsky, ... of the Center for Excellence in the Neurosciences (CEN), ... England, has been selected as a member of the ... the first neuroscientist from Maine to receive this honor. ... organization supported entirely by the Dana Foundation. Its ...
(Date:12/19/2014)... The empty capsules market is ... population and technological innovations in the empty capsules ... catalysing the growth of the empty capsules market. ... , Scope of Report , The report will ... entrants/smaller firms to gauge the pulse of the ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... politics aside, every biologist knows that men and women truly ... area where those differences come to the fore: around 80 ... Social play behaviors also differ greatly between the sexes - ... girls. , ,Early in human development, critical brain proteins known ...
... The life sciences company Promega announced on Tuesday a ... that had been pending before the U.S. District Court ... Promega will hold a worldwide non-exclusive license from Benitec ... DNA-directed RNA interference (ddRNAi) technology. Promega will also receive ...
... an online provider of digital sheet music, announced on Tuesday ... Group to provide Word Music's collection of Christian music on ... , ,Word Music, a division of Warner Music Group based ... music from Christian songwriters such as Amy Grant, Point Of ...
Cached Biology Technology:Gender hormones may lend to social disorder therapies 2