Navigation Links
Fighting sleep, Penn researchers reverse the cognitive impairment caused by sleep deprivation

PHILADELPHIA - A research collaboration led by biologists and neuroscientists at the University of Pennsylvania has found a molecular pathway in the brain that is the cause of cognitive impairment due to sleep deprivation. Just as important, the team believes that the cognitive deficits caused by sleep deprivation, such as an inability to focus, learn or memorize, may be reversible by reducing the concentration of a specific enzyme that builds up in the hippocampus of the brain.

It is known that sleep deprivation can have cognitive consequences, including learning and memory deficits, but the mechanisms by which sleep deprivation affects brain function remain unknown. A particular challenge has been to develop approaches to reverse the impact of sleep deprivation on cognitive function.

The findings, reported in this week's issue of the journal Nature, could present a new approach to treating the memory and learning deficits of insomnia. A molecular mechanism by which brief sleep deprivation alters hippocampal function is now identified in mice, involving the impairment of cyclic-AMP- and protein-kinase-A-dependent forms of synaptic plasticity, or readiness for cognitive function.

Ted Abel, principal investigator and professor of biology in the School of Arts and Sciences at the University of Pennsylvania, led the international team of researchers that found that sleep deprivation in mice affects an important molecular pathway in the hippocampus, a region of the brain known to be important for memory and learning.

The study showed that mice deprived of sleep had increased levels of the enzyme PDE4 and reduced levels of the molecule cAMP, the latter of which is crucial in forming new synaptic connections in the hippocampus, a physiological hallmark of learning.

Researchers then treated the mice with PDE inhibitors, which rescued the sleep deprivation-induced deficits in cAMP signaling, synaptic plasticity and hippocampus dependent memory. This reversal also helped to rescue deficits in synaptic connections in the hippocampus and therefore counteract some of the memory consequences of sleep deprivation.

"Millions of people regularly obtain insufficient sleep," Abel said. "Our work has identified a treatment in mice that can reverse the cognitive impact of sleep deprivation. Further, our work identifies specific molecular changes in neurons caused by sleep deprivation, and future work on this target protein promises to reveal novel therapeutic approaches to treat the cognitive deficits that accompany sleep disturbances seen in sleep apnea, Alzheimer's disease and schizophrenia."


Contact: Jordan Reese
University of Pennsylvania

Related biology news :

1. Diabetes drug shows promise in fighting lethal cancer complication
2. Georgia State researcher to use $1 million grant to improve computer models for fighting wildfires
3. Master gene that switches on disease-fighting cells identified by scientists
4. Fighting the burden of mental disorders
5. U-Iowa improves delivery of cancer-fighting molecules
6. Rabbits on the back foot -- but naturally theyre fighting back
7. Novel lung cancer vaccine shows promise in fighting early-stage lung cancer
8. Fighting global warming offers growth and development opportunities
9. Fighting obesity and illness with a novel approach to nutrition
10. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
11. Children distressed by family fighting have higher stress hormones
Post Your Comments:
(Date:11/17/2015)... -- Vigilant Solutions announces today that Mr. Dick W. ... --> --> Mr. Boyce ... at TPG Capital, one of the largest global investment ... revenue.  He founded and led TPG,s Operating Group, which ... 1997 to 2013.  In his first role, he served ...
(Date:11/12/2015)... Nov. 12, 2015  Arxspan has entered into ... and Harvard for use of its ArxLab cloud-based ... tools. The partnership will support the institute,s efforts ... chemical research information internally and with external collaborators. ... for managing the Institute,s electronic laboratory notebook, compound ...
(Date:11/10/2015)... 10, 2015 About signature ... helps to identify and verify the identity of ... as the secure and accurate method of authentication ... particular individual because each individual,s signature is highly ... when dynamic signature of an individual is compared ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... ... December 01, 2015 , ... ... marketing company specializing in scientifically backed, age-defying products, is featured as the ... highlights the exponential success and unrivaled opportunities that Nerium provides. Success from ...
(Date:12/1/2015)... -- Cepheid (Nasdaq: CPHD ) today announced that, ... Healthcare Conference in New York City ... outlook for the fourth quarter of 2015 and initiating ... term business model expectations. John Bishop , ... be the fastest growing company of the major market ...
(Date:12/1/2015)... ... 2015 , ... The American Society of Gynecologic Laparoscopists, AAGL, ... will join fellow surgeons in the shared pursuit of “advancing minimally invasive ... founder of Plano Urogynecology Associates and Fellow of the American College of ...
(Date:12/1/2015)... , December 1, 2015 ... addition of the  "2016 U.K. Virology and ... Forecasts for 100 Tests, Supplier Shares by ...  report to their offering.  --> ... the  "2016 U.K. Virology and Bacteriology Testing ...
Breaking Biology Technology: