Navigation Links
Fighting melanoma's attraction to the brain
Date:9/19/2012

The process of metastasis, by which cancer cells travel from a tumor site and proliferate at other sites in the body, is a serious threat to cancer patients. According to the National Cancer Institute, most recurrences of cancer are metastases rather than "new" cancers.

Virtually all types of cancer can spread to other parts of the body, including the brain. Once metastatic melanoma cells are entrenched in the brain, patients typically have only a few months to live.

Now Prof. Isaac Witz and his team at Tel Aviv University's Department of Cell Research and Immunology are delving deeper into what attracts metastatic melanoma cells to the brain, and how they survive and prosper in this environment. Their experiments have discovered that melanoma cells produce receptors for two chemokines a family of small proteins secreted by cells present in the brain tissue. These receptors may act as a homing device, drawing the cancerous cells to the brain.

"These interactions between the chemokines in the brain and the melanoma cell receptors could be potential targets for new therapies," Prof. Witz says. "With medications that suppress these molecules, you could hope to interfere with this specific migration." Published in the International Journal of Cancer, this research is supported by the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation.

A dangerous attraction

Although metastasis is a well-understood process, researchers are still trying to uncover the underlying mechanisms of why cancer cells begin to migrate in the first place. It is also crucial to understand what allows them to sustain themselves, divide, and propagate once they have arrived at their new location.

To better understand metastacized melanoma cells in the brain, the researchers cultured brain tissue in the lab, then analyzed all of the materials that were expressed by the cells. They identified certain chemokine
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Preventing home invasions means fighting side-by-side for coral-dwelling crabs and shrimp
2. Study finds cancer-fighting goodness in cholesterol
3. Trial launched into curry chemicals cancer-fighting properties
4. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
5. Fighting bacterias strength in numbers
6. UGA study reveals flu-fighting role for well-known immune component
7. La Jolla institute identifies critical cell in fighting E. coli infection
8. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
9. Nematodes with pest-fighting potential identified
10. Research finds novel airborne germ-killing oral spray effective in fighting colds and flu
11. REST is crucial for the timing of brain development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fighting melanoma's attraction to the brain
(Date:8/28/2014)... million kilometres of new roads will be built worldwide ... Earth,s last wildernesses, where they bring an influx of ... an ambitious study has created a ,global roadmap, for ... balance the competing demands of development and environmental protection. ... that estimates that natural importance of ecosystems and a ...
(Date:8/28/2014)... California, and Alaska totaled 515 million board feet in ... of more than 10 percent compared to the first ... Research Station reported today. During this same period, West ... million board feet. , The total value of these ... $390 million in the same quarter, while the total ...
(Date:8/27/2014)... single fungal cell or bacterial colony exerts on a plant ... role in setting up some of the most fundamental symbiotic ... much of a stretch to say that plants may have ... the touch of beneficial fungi, according to a new study ... University of Wisconsin-Madison. , "Many people have studied how ...
Breaking Biology News(10 mins):Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3West coast log exports up, lumber exports down in second quarter of 2014 2A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3
... could become even more prevalent and destructive as climate change ... more than 150 years. Writing in the journal ... study say that non-native plants, and especially invasive species, appear ... able to adjust the timing of annual activities like flowering ...
... Charles Drew University of Medicine and Science is investigating the ... therapy for cancer. Dr. Mamdooh Ghoneum presented his findings ... Mechanism," sponsored by the American Association for Cancer Research (AACR) ... "The central focus of the meeting is cell death ...
... A 60-million-year-old relative of crocodiles described this week by ... Vertebrate Paleontology was likely a food source for ... Working with scientists from the Smithsonian Tropical Research ... Natural History on the UF campus found fossils of ...
Cached Biology News:Invasive plants are beneficiaries of climate change in Thoreau's woods 2Charles Drew cancer studies with yeast yield excellent results 2UF researchers: Ancient crocodile relative likely food source for Titanoboa 2UF researchers: Ancient crocodile relative likely food source for Titanoboa 3
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/28/2014)... August 28, 2014 Whitehouse Laboratories is ... term partnership with PTI Inspection Systems that ... state of the art leak testing method development and ... instruments currently available. As part of this agreement, Whitehouse ... Voltage Leak Detection Instrument developed and manufactured by ...
(Date:8/27/2014)... 27, 2014 In 2013, ... Lawrence Livermore National Security LLC (LLNS), was ... deliver a state-of-the-art laser system for the European ... under construction in the Czech Republic. , When ... system, called the " High repetition-rate Advanced Petawatt ...
(Date:8/27/2014)... 2014 The Global and China Trifluoroacetic ... the current state of the Trifluoroacetic Acid industry in ... overview of the industry, including definitions, applications and industry ... analysis are provided with a focus on history, developments, ... between the international and Chinese situation is also offered. ...
Breaking Biology Technology:2 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... ,S-HERTOGENBOSCH, The Netherlands , April 28, 2010 , Pepscan, ... for the generation of immune therapeutics, today,announced that it reached a ... Under the terms of the,agreement Pepscan will receive an undisclosed cash ... , , ...
... The Netherlands , April 27, 2010 Immunovo,BV, a new ... insights in oncology to develop novel,therapeutics, secures seed funding from Dutch venture ... ... - Immunovo BV, a new,biotechnology company developing a novel technology platform for ...
... April 27 The Johns Hopkins University School of Medicine ... collaborative program to advance the development and use of stem cells in therapies ... train researchers to use stem cells and foster joint research projects. , ... The collaborative program will encompass training for ...
Cached Biology Technology:Pepscan Signs Partnering Agreement With Immunovo for its Therapeutic Vaccine Portfolio 2Pepscan Signs Partnering Agreement With Immunovo for its Therapeutic Vaccine Portfolio 3Immunovo BV- A New Biotechnology Company is Announced 2The New York Stem Cell Foundation and The Johns Hopkins University School of Medicine to Collaborate on Stem Cell Research 2The New York Stem Cell Foundation and The Johns Hopkins University School of Medicine to Collaborate on Stem Cell Research 3The New York Stem Cell Foundation and The Johns Hopkins University School of Medicine to Collaborate on Stem Cell Research 4The New York Stem Cell Foundation and The Johns Hopkins University School of Medicine to Collaborate on Stem Cell Research 5