Navigation Links
Fighting melanoma's attraction to the brain
Date:9/19/2012

The process of metastasis, by which cancer cells travel from a tumor site and proliferate at other sites in the body, is a serious threat to cancer patients. According to the National Cancer Institute, most recurrences of cancer are metastases rather than "new" cancers.

Virtually all types of cancer can spread to other parts of the body, including the brain. Once metastatic melanoma cells are entrenched in the brain, patients typically have only a few months to live.

Now Prof. Isaac Witz and his team at Tel Aviv University's Department of Cell Research and Immunology are delving deeper into what attracts metastatic melanoma cells to the brain, and how they survive and prosper in this environment. Their experiments have discovered that melanoma cells produce receptors for two chemokines a family of small proteins secreted by cells present in the brain tissue. These receptors may act as a homing device, drawing the cancerous cells to the brain.

"These interactions between the chemokines in the brain and the melanoma cell receptors could be potential targets for new therapies," Prof. Witz says. "With medications that suppress these molecules, you could hope to interfere with this specific migration." Published in the International Journal of Cancer, this research is supported by the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation.

A dangerous attraction

Although metastasis is a well-understood process, researchers are still trying to uncover the underlying mechanisms of why cancer cells begin to migrate in the first place. It is also crucial to understand what allows them to sustain themselves, divide, and propagate once they have arrived at their new location.

To better understand metastacized melanoma cells in the brain, the researchers cultured brain tissue in the lab, then analyzed all of the materials that were expressed by the cells. They identified certain chemokine
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Preventing home invasions means fighting side-by-side for coral-dwelling crabs and shrimp
2. Study finds cancer-fighting goodness in cholesterol
3. Trial launched into curry chemicals cancer-fighting properties
4. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
5. Fighting bacterias strength in numbers
6. UGA study reveals flu-fighting role for well-known immune component
7. La Jolla institute identifies critical cell in fighting E. coli infection
8. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
9. Nematodes with pest-fighting potential identified
10. Research finds novel airborne germ-killing oral spray effective in fighting colds and flu
11. REST is crucial for the timing of brain development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fighting melanoma's attraction to the brain
(Date:12/19/2014)... --  LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ... bring LaunchKey to market in 2015. LaunchKey ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... embryo formation in the lowly fruit fly, a little ... to a study in the Oct. 14 Developmental ... While the fundamentals of this tiny bug,s reproductive ... quite a bit to humans. That,s because the study ...
... why people who eat more fruit and vegetables may gain ... that a fragment released from pectin, found in all fruits ... 3 (Gal3), a protein that plays a role in all ... effects of foods are based on population studies," says Professor ...
... TALLAHASSEE, Fla. -- In a groundbreaking study led by ... have discovered that as embryonic stem cells turn into ... the order in which DNA is replicated and reorganized. ... stem cell biologists, enabling them to better understand the ...
Cached Biology News:Scientists trace molecular origin of proportional development 2Scientists trace molecular origin of proportional development 3Pectin power 2Landmark study unlocks stem cell, DNA secrets to speed therapies 2Landmark study unlocks stem cell, DNA secrets to speed therapies 3
(Date:12/24/2014)... , Dec. 23, 2014 Vermillion, ... focused on gynecologic disease, announced today that investors ... , Birchview Fund LLC and several Vermillion directors ... unregistered shares of Vermillion,s common stock and warrants ... in a private placement.  Under ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 /PRNewswire/ ... study of mazindol in children with attention deficit/hyperactivity disorder ... December 2014 . The paper, titled ... attention deficit/hyperactivity disorder" ( Konofal et al, ... eCollection 2014 ) shows that mazindol might be ...
(Date:12/22/2014)... , Dec. 22, 2014  Alternative Energy ... that it has signed a letter of intent ... has developed and patented a nanotechnology-based development platform ... products that enable rapid on-site collection and testing ... and health issues in an immediate, non-invasive and ...
(Date:12/22/2014)... Illinois (PRWEB) December 22, 2014 ITRA ... tenants and occupiers of commercial real estate, has further ... new offices in Perth and Brisbane, Western Australia, reports ... of directors. , ITRA Global / ACORPP (Australian ... totally independent consultancy company providing property services to a ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2
... ... ... -- The American Medical Writers Association named medical writer, Rita Buckley, Writer/Owner of ... in Medical Communication. She received the awards for The Lehman Series Expert Panel on ...
... June 11, 2010 Researchers at Texas A&M University College ... first with the successful delivery of a foal using oocytes ... world. The delivery of the foal highlights Texas A&M,s long ... a great experience for the owner of the new foal., ...
... world,s smallest chess board about the diameter of ... winners in this year,s design contest for, respectively, novel ... Laboratories in mid May. The two winning teams ... one of the most advanced in the world. ...
Cached Biology Technology:Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 2Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 3Texas A&M veterinary researchers achieve cloning first 2Texas A&M veterinary researchers achieve cloning first 3Texas Tech, U of Utah win Sandia microdevice competition 2Texas Tech, U of Utah win Sandia microdevice competition 3Texas Tech, U of Utah win Sandia microdevice competition 4
... Microarrays designed for RNA aptamer screening ... flexible and powerful Paraflo microfluidic on-chip synthesis ... can be synthesized on-chip and LC Sciences ... These microarrays are available as part of ...
... LX80L is an extension of Parkers MX80 family ... compact cross-section. LX80L bolt hole patterns mimic the ... units and all accessory brackets to build multi-axis ... travel to 750 mm , Accelerations to 5 ...
... is compatible with BioTeks microplate washers, ... of use and walkaway automation are ... When used with the ELx405 washer ... Bio-Stacks small footprint fits easily in ...
... the use of small interfering RNA (siRNA) ... RNA interference (RNAi) pathway have generated tremendous ... fields. siRNA for experimental use can be ... and then transfected into the target cells ...
Biology Products: