Navigation Links
Fighting fungal infections with bacteria
Date:4/30/2010

A bacterial pathogen can communicate with yeast to block the development of drug-resistant yeast infections, say Irish scientists writing in the May issue of Microbiology. The research could be a step towards new strategies to prevent hospital-acquired infections associated with medical implants.

Researchers from University College Cork in Ireland studied the interaction between the bacterium Pseudomonas aeruginosa, which is often associated with severe burns, and the yeast Candida albicans, which can grow on plastic surfaces such as catheters. Both microbes are very common and although they are normally harmless to healthy individuals, they can cause disease in immunocompromised people.

The team discovered that molecules produced by P. aeruginosa bacteria were able to hinder the development of C. albicans 'biofilms' on silicone, when the yeast cells clump together on the surface of the plastic. Interestingly, the interaction between the two organisms did not depend on the well-studied bacterial communication system called Quorum Sensing, indicating that a novel signalling mechanism was at play.

C. albicans is the most common hospital-acquired fungal infection and can cause illness by sticking to and colonising plastic surfaces implanted in the body such as catheters, cardiac devices or prosthetic joints. This biofilm formation is a key aspect of C. albicans infection and is problematic as biofilms are often resistant to the antibiotics used to treat them. Dr John Morrissey, who led the team of researchers, said, "Candida albicans can cause very serious deep infections in susceptible patients and it is often found in biofilm form. It is therefore important to understand the biofilm process and how it might be controlled."

Dr Morrissey believes his work may lead to significant clinical benefits. "If we can exploit the same inhibitory strategy that the bacterium P. aeruginosa uses, then we might be able to design drugs that can be used as antimicrobials to disperse yeast biofilms after they form, or as additives onto plastics to prevent biofilm formation on medical implants," he said. "The next steps are to identify the chemical that the bacterium produces and to find out what its target in the yeast is. We can then see whether this will be a feasible lead for the development of new drugs for clinical application."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related biology news :

1. Social habits of cells may hold key to fighting diseases
2. When it comes fighting to C. difficile, the Palme dOr goes to soap and warm water
3. Fighting the spread of food poisoning
4. Gold nanorods shed light on new approach to fighting cancer
5. UV light improving chances of fighting cancer
6. Researchers uncover key trigger for potent cancer-fighting marine product
7. Fighting pollution the poplar way: Trees to clean up Indiana site
8. Fighting Aussie yabbies dont forget a face -- new research by the University of Melbourne
9. Strengthening the tumor-fighting ability of T cells
10. FSU researcher using computers to hone cancer-fighting strategies
11. UCSB study finds physical strength, fighting ability revealed in human faces
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fighting fungal infections with bacteria
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/9/2016)... 2016  Perkotek an innovation leader in attendance control systems is proud to announce ... for employers to make sure the right employees are actually signing in, and to ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the ... Convention Center and will showcase its product’s latest features from June 26 to ... a scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology: