Navigation Links
Fighting fungal infections with bacteria
Date:4/30/2010

A bacterial pathogen can communicate with yeast to block the development of drug-resistant yeast infections, say Irish scientists writing in the May issue of Microbiology. The research could be a step towards new strategies to prevent hospital-acquired infections associated with medical implants.

Researchers from University College Cork in Ireland studied the interaction between the bacterium Pseudomonas aeruginosa, which is often associated with severe burns, and the yeast Candida albicans, which can grow on plastic surfaces such as catheters. Both microbes are very common and although they are normally harmless to healthy individuals, they can cause disease in immunocompromised people.

The team discovered that molecules produced by P. aeruginosa bacteria were able to hinder the development of C. albicans 'biofilms' on silicone, when the yeast cells clump together on the surface of the plastic. Interestingly, the interaction between the two organisms did not depend on the well-studied bacterial communication system called Quorum Sensing, indicating that a novel signalling mechanism was at play.

C. albicans is the most common hospital-acquired fungal infection and can cause illness by sticking to and colonising plastic surfaces implanted in the body such as catheters, cardiac devices or prosthetic joints. This biofilm formation is a key aspect of C. albicans infection and is problematic as biofilms are often resistant to the antibiotics used to treat them. Dr John Morrissey, who led the team of researchers, said, "Candida albicans can cause very serious deep infections in susceptible patients and it is often found in biofilm form. It is therefore important to understand the biofilm process and how it might be controlled."

Dr Morrissey believes his work may lead to significant clinical benefits. "If we can exploit the same inhibitory strategy that the bacterium P. aeruginosa uses, then we might be able to design drugs that can be used as antimicrobials to disperse yeast biofilms after they form, or as additives onto plastics to prevent biofilm formation on medical implants," he said. "The next steps are to identify the chemical that the bacterium produces and to find out what its target in the yeast is. We can then see whether this will be a feasible lead for the development of new drugs for clinical application."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related biology news :

1. Social habits of cells may hold key to fighting diseases
2. When it comes fighting to C. difficile, the Palme dOr goes to soap and warm water
3. Fighting the spread of food poisoning
4. Gold nanorods shed light on new approach to fighting cancer
5. UV light improving chances of fighting cancer
6. Researchers uncover key trigger for potent cancer-fighting marine product
7. Fighting pollution the poplar way: Trees to clean up Indiana site
8. Fighting Aussie yabbies dont forget a face -- new research by the University of Melbourne
9. Strengthening the tumor-fighting ability of T cells
10. FSU researcher using computers to hone cancer-fighting strategies
11. UCSB study finds physical strength, fighting ability revealed in human faces
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fighting fungal infections with bacteria
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a medical ... (IV) therapy, today announced receipt of its ISO 13485 Certification, the ... the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection ... "This is an important ...
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their boarding ... ... biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at the ... to allow eligible Delta SkyMiles Members who are enrolled in CLEAR to ...
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... ... Asian exhibitions for analytical and scientific instruments. This year’s symposium, organized by the ... in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss novel ionization ...
(Date:8/15/2017)... ... August 15, 2017 , ... The Conference Forum and ... programming through a series of upcoming panels and events. The partnership culminates with the ... Roosevelt Hotel in New York City. , “With our experience in producing the Immuno-Oncology ...
(Date:8/14/2017)... Yorba Linda, Ca (PRWEB) , ... August 14, ... ... allocated for poorly characterized and performing antibodies. Key researchers in the antibody community ... ensure proper characterization and consistency for antibodies in the laboratory. , ...
(Date:8/11/2017)... 2017  Market researcher Kalorama Information was ... regarding the telemedicine market.  The telemedicine market ...  The article, "Heart and Asthma Monitors? ... information from Kalorama Information,s Remote Patient Monitoring ...  (Sleep, Diabetes, Vital Signs /EKG and ...
Breaking Biology Technology: