Navigation Links
Fighting bacteria's strength in numbers
Date:5/17/2012

Scientists at The University of Nottingham have opened the way for more accurate research into new ways to fight dangerous bacterial infections by proving a long-held theory about how bacteria communicate with each other.

Researchers in the University's School of Molecular Medical Sciences have shown for the first time that the effectiveness of the bacteria's communication method, a process called 'quorum sensing', directly depends on the density of the bacterial population. This work will help inform wider research into how to stop bacteria talking to each other with the aim of switching off their toxin production.

As some pathogenic organisms are increasingly resistant to traditional antibiotics, medical researchers around the world, including scientists at The University of Nottingham, are trying to find other ways of fighting infection. This new work involves using 'quorum quenching' compounds which interfere with bacterial signalling and disrupt their social lives.

Quorum sensing (QS) is the process by which bacteria communicate and co-operate using signal molecules which control, among other things, the production of toxins. QS is therefore an important factor in a number of bacterial species that cause serious infection in humans including Pseudomonas aeruginosa, a leading cause of death among cystic fibrosis sufferers, and MRSA which is a huge clinical problem in hospitals.

Leading the research at Nottingham, Dr Stephen Diggle said: "The fundamental assumption used to explain QS, is that the production of QS-controlled factors is not beneficial until a sufficient density of cells (a quorum) is present, and that the purpose of QS is to stimulate social behaviours only when high enough bacterial population densities are reached. For a pathogen this makes sense. Why produce toxins when there are not many cells around? Why not wait until a large number are present and coordinate production of toxin on mass which help
'/>"/>

Contact: Emma Rayner
emma.rayner@nottingham.ac.uk
44-115-951-5793
University of Nottingham
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UCSB study finds physical strength, fighting ability revealed in human faces
2. Children distressed by family fighting have higher stress hormones
3. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
4. Fighting obesity and illness with a novel approach to nutrition
5. Fighting global warming offers growth and development opportunities
6. Novel lung cancer vaccine shows promise in fighting early-stage lung cancer
7. Rabbits on the back foot -- but naturally theyre fighting back
8. U-Iowa improves delivery of cancer-fighting molecules
9. Fighting the burden of mental disorders
10. Master gene that switches on disease-fighting cells identified by scientists
11. Georgia State researcher to use $1 million grant to improve computer models for fighting wildfires
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fighting bacteria's strength in numbers
(Date:6/1/2015)... June 1, 2015 According to ... Sensing Market by Technology (Touch-based & Touchless), Application (Consumer ... & by Geography - Global Forecast to 2020", published ... is expected to reach $23.55 Billion by 2020, at ... Browse 83 market data T ables ...
(Date:6/1/2015)... 1, 2015 According to ... Market by Application (Government, Military & Defense, Healthcare, ... and Security), Technology (Face Recognition, Fingerprint Recognition, Iris ... Recognition, and Others), Function (Contact and Non-Contact) & ... Europe , APAC, Row) - Global ...
(Date:5/29/2015)... , May 28, 2015 Research ... addition of the "Facial Recognition Market by ... - Global Forecast to 2020" report to ... have seen facial recognition technology become more efficient ... to gain traction and investment from the commercial ...
Breaking Biology News(10 mins):Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 2Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 3Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 4Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4Global advanced Facial Recognition Market Expected to Grow From $2.77 Billion in 2015 to $6.19 Billion in 2020, at an Estimated CAGR of 17.4% 2
... a remote region of the Russian mountains a previously unknown ... Lead Scientist Professor Hans Cornelissen and his Russian-Dutch team describe ... root belongs to the small alpine plant Corydalis conorhiza and ... through layers of snow. Given this novel behaviour, the scientists ...
... In a study published in the open-access, peer-reviewed ... Han and Piotr Jablonski at Seoul National University, Korea, ... their genitalia from males, forceful copulatory attempts, females of ... the evolutionary arms race between the sexes. Instead, females ...
... are acclaimed in representing natural climate archives. For ... of these annual rings depend mainly on temperature and ... seasonal variations, the correlation is not so evident. ... Geosciences and their colleagues of the Australian National University ...
Cached Biology News:Newly discovered snow roots are 'evolutionary phenomenon' 2Hidden genitalia in female water striders makes males 'sing' 2Australia's climate: Drought and flooding in annual rings of tropical trees 2
(Date:6/2/2015)... 2015 German-based Moenninghoff has designated the ... for the Moenninghoff product line . ... to announce that the R.M. Hoffman Company will be ... founded in 1916, this is a strategically important step. ... kind of professional distributor we need to successfully grow ...
(Date:6/1/2015)... YONGIN, South Korea , June 1, ... Green Cross Biotherapeutics Inc. (GCBT) kicked off construction today ... the Montreal Technoparc,s Saint-Laurent Campus. The CA$315 million project ... in Canada in the biopharmaceutical ... intravenous immunoglobulin (IVIG) and albumin manufacturing plant in ...
(Date:6/1/2015)... HANOVER, N.J. , June 1, 2015 /PRNewswire/ ... II clinical study of CTL019, an investigational chimeric ... its potential in the treatment of specific types ... study conducted by the University of Pennsylvania,s Perelman ... or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) ...
(Date:6/1/2015)... N.C. , June 1, 2015  Fennec ... presentation of positive interim results from a poster ... multi-centre open label randomised phase III trial of ... ototoxicity in patients receiving cisplatin (Cis) monotherapy for ... at the American Society of Clinical Oncology (ASCO) ...
Breaking Biology Technology:R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 2R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 3Green Cross Biotherapeutics Kicks Off Construction in Montreal 2Green Cross Biotherapeutics Kicks Off Construction in Montreal 3Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 2Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 3Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 4Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 5Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 6Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 2Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 3Fennec Announces Presentation Of Positive Interim Sodium Thiosulfate Phase III Safety Data At The 2015 ASCO Annual Meeting 4
... for 15 minutes, couldn't imagine the influence the Internet, blogging, social ... these tools, everyone can have their 15 minutes - but just ... is about all anyone has time for these days, at least ... reminded of this after coming back from a near three-week holiday ...
... the lead cancer drug candidate of Madison's Quintessence Biosciences ... Food and Drug Aministration for being tested on cancer ... meeting of the American Association for Cancer Research , ... scale and applied in safe doses, the company announced. , ...
... Madison, Wis . - Mithridion, Inc ., a biopharmaceutical ... of Alzheimer's disease, has closed an additional $1.2 million of ... , ,The latest round of funding brings the total equity ... above the company's initial funding target. Mithridion will use the ...
Cached Biology Technology:On the Web, attention spans shrink, the need for value rises 2On the Web, attention spans shrink, the need for value rises 3Quintessence Biosciences advances cancer drug 2Alzheimer's drug developer lands $1.2M in venture funding 2Alzheimer's drug developer lands $1.2M in venture funding 3