Navigation Links
Fewer deaths with preventive antibiotic use
Date:12/31/2008

Administering antibiotics as a preventive measure to patients in intensive care units (ICUs) increases their chances of survival. This has emerged from a study involving nearly sixthousand Dutch patients in thirteen hospitals. Researchers at University Medical Center (UMC) Utrecht have published their findings in an article in The New England Journal of Medicine.

During the study, a team of researchers compared the effect of two kinds of antibiotic treatments with the standard ICU care. They divided into three groups nearly six thousand patients hospitalized in ICUs between 2004 and 2006. The patients in question were expected to be on a ventilator for at least two days and/or to be admitted to the ICU for at least three days. One of the groups received an oral antibiotic paste four times a day. The second group, in addition to being given the oral paste four times daily, received antibiotics through a gastric tube in the intestinal tract and by intravenous drip. The third group was the control group and received the standard ICU care.

After four weeks, fewer people had died in the groups that received antibiotics than in the control group. Preventive use of antibiotics reduced the number of deaths by 3.5 percent (oral antibiotic paste, and antibiotics in the intestinal tract and by intravenous drip) and 2.9 percent (oral antibiotic paste). The difference between the two groups treated with antibiotics was not significant. The number of antibiotic-resistant bacteria did not increase in these patients. Although the patients in the control group were in general slightly less sick, the statistical data were adjusted to reflect this.

The findings have settled a long-running debate on whether the advantages of using antibiotics as a preventive measure offset the drawback of the possibility of developing antibiotic resistance. For Dr. Anne Marie de Smet, anesthesiologist-intensivist at UMC Utrecht and the article's first author, the conclusion is clear.

In the Netherlands, every year more than 18,000 patients are hospitalized in ICUs for more than three days. "I believe we should revise the antibiotic policy for the ICU," says De Smet. "Because the study was conducted in thirteen Dutch hospitals, the conclusions can be implemented throughout the country. We have seen that using antibiotics clearly results in a reduction in the number of deaths, and ICUs should make use of this knowledge." The study was too short to be able to provide any insight into how resistance develops in the long term, and this will require further research.


'/>"/>

Contact: Mrs. Linda Minnen
press@umcutrecht.nl
31-887-555-555
University Medical Center Utrecht
Source:Eurekalert

Related biology news :

1. Fewer babies born after Caesarean delivery
2. Warmer springs mean less snow, fewer flowers in the Rockies
3. New technology aims to reduce maternal and neonatal deaths
4. Study shows rise in Cornwalls dolphin, whale and porpoise deaths
5. Human deaths from shark attacks hit 20-year low last year
6. Earlier bites by uninfected mosquitoes boost West Nile deaths in lab mice
7. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
8. Researchers identify cancer preventive properties in common vitamin supplement
9. Transporting broiler chickens could spread antibiotic-resistant organisms
10. Biomedical engineers detective work reveals antibiotic mechanism
11. New antibiotic candidates from Braunschweig
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... ... ... Anton Paar USA, located in Ashland, Virginia is pleased to announce that ... adds a third office building to the current facilities. , Growth is nothing ... along with office space adjacent to the previous main building. Through remodels and new ...
(Date:5/19/2016)... Regen BioPharma, Inc ... announced today initiation of a preclinical development program ... cancer immunotherapeutic product leveraging its NR2F6 immunological checkpoint. ... generation of cord blood derived killer cells whose ... product in development will be a "universal donor" ...
(Date:5/18/2016)... The Biotech industry continues to face ... there are no opportunities ahead. Today, ActiveWallSt.com has on its ... THLD ), Seattle Genetics Inc. (NASDAQ: SGEN ), ... (NASDAQ: OPHT ). Sign up now to receive ... http://www.activewallst.com/ Threshold Pharmaceuticals Inc.,s shares gained 0.68%, ...
(Date:5/18/2016)... ... 18, 2016 , ... Ryan Benton was diagnosed with Duchenne Muscular Dystrophy (DMD) ... to early twenties. DMD is a relatively common progressive genetic disorder, which causes aggressive ... condition was critical. He met with the founder of the Stem Cell Institute ...
Breaking Biology Technology: