Navigation Links
Fetal stress disrupts the way genes are transmitted
Date:8/1/2013

Bethesda, MD -- If you think stress is killing you, you may be right, but what you don't know is that stress might have harmed your health even before you were born. In a new report appearing in the August 2013 issue of The FASEB Journal, Harvard researchers find that epigenetic disruptions, which are associated with chronic disease later in life, are already common at birth. Possibly, these aberrations result from stressors in the intrauterine environment (e.g. maternal smoking, maternal diet, or high levels of endocrine-disrupting chemicals). This finding supports the belief that seeds of disease are sown before birth, increasing the importance of optimal prenatal care.

"This study may help us understand whether epigenetic mechanisms contribute to chronic disease susceptibility already prior to birth," said Karin Michels, Sc.D., Ph.D., study author from Harvard Medical School in Boston, Mass. "We are currently exploring which stressors during prenatal life may contribute to these epigenetic disruptions."

To make this discovery, Michels and colleagues examined the expression pattern of imprinted genes important for growth and development. Researchers analyzed the parental expression pattern in the cord blood and placenta of more than 100 infants and followed up this analysis with methylation and expression studies. The results lent credence to the emerging theme that susceptibility to disease may indeed originate in utero. Additionally, this research showed that a high degree of disruption occurred during the imprinting of a gene called IGF2, which was expressed from both alleles in the cord blood of 22 percent of study subjects. Loss of imprinting of IGF2 has been associated with several cancers, including Wilms Tumor, colorectal and breast cancer and childhood disorders such as Beckwith-Wiedemann Syndrome.

"For a long time, doctors have considered fetal stress as a symptom of serious familial disease," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Now, we see that fetal stress is in and of itself a long-term risk factor for chronic disease: it changes the way we inherit genes from our parents."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Fetal exposure to PVC plastic chemical linked to obesity in offspring
3. Pandemic vaccination did not increase risk of fetal death
4. Signaling pathway linked to fetal alcohol risk
5. New genetic link found between normal fetal growth and cancer
6. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
7. CWRU dental researchers NIDCR grant targets oral bacteria and fetal death link
8. New protocol developed to decontaminate human fetal tissues used for cell transplantation
9. Fetal programming of sweet tastes elicited pleasure
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Some corals like it hot: Heat stress may help coral reefs survive climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2017)... ANTONIO , Feb. 3, 2017  Texas Biomedical Research ... Dr. Larry Schlesinger as the Institute,s new ... Texas Biomed effective May 31, 2017. He is currently the ... Director of the Center for Microbial Interface Biology at Ohio ... Schlesinger as the new President and CEO of Texas Biomed," ...
(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, ... clinical-stage immuno-oncology company specializing in the development of ... the treatment of cancer and metastatic disease, announced ... and GMP manufacturing of a second clinical lot ... targeting folate receptor alpha. The manufactured vaccine product ...
(Date:2/2/2017)... -- Central to its deep commitment to honor the ... Prize Foundation today announced the laureates of the ... in their respective fields of Life Sciences and ... recognized with the 2017 Japan Prize for original ... the advancement of science and technology, but also ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... ... February 17, 2017 , ... Academy of Model Aeronautics ... leading maker of unmanned aircraft systems (UAS), are launching a joint program to ... effectively, and support educational outreach efforts. , AMA and DJI will collaborate on ...
(Date:2/16/2017)... (PRWEB) , ... February 16, 2017 , ... Avomeen & ... The event will be held at Avomeen Analytical Services (4840 Venture Dr., Ann ... MichBio member organization. They provide an opportunity to interact with peers, make new connections ...
(Date:2/16/2017)... , Feb. 16, 2017  MDNA Life Sciences ... development of liquid biopsy tests based on the ... an exclusive license agreement with its first international ... liquid biopsy test for prostate cancer, the Prostate ... . This is the first overseas appointment ...
(Date:2/16/2017)... 16, 2017   Capricor Therapeutics, Inc. ... company developing first-in-class biological therapies for cardiac and ... elected to terminate its license agreement with the ... including Cenderitide. "Our decision to return ... prioritize our efforts to advance our core cell ...
Breaking Biology Technology: