Navigation Links
Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
Date:8/22/2013

Putnam Valley, NY. (Aug. 22, 2013) Patients receiving cranial irradiation treatment for brain cancer may find the treatment life-saving, but often suffer progressive and debilitating cognitive detriments, including spatial learning and memory deficits. The cognitive deficits are a contributing factor to the often significant adverse impacts on the surviving patients' quality of life after radiation therapy. In an effort to improve post-irradiation cognitive impairment, scientists at the University of California, Irvine, and colleagues at Neuralstem, Inc. (Rockville, MD), have transplanted fetal stem cells into laboratory animals with radiation-induced cognitive impairments and found that this led to a number of cognitive improvements. The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct1048acharya.

"Multiple mechanisms contribute to disrupted cognition following irradiation for patients with central nervous system malignancies. These include the depletion of radiosensitive populations of stem and progenitor cells in the hippocampus," said study co-author Dr. Charles L. Limoli of the Department of Radiation Oncology at the University of California, Irvine. "Interventions to combat long-term brain damage resulting from toxic radiation and chemotherapies therapies have yet to be developed. However, stem cell replacement strategies may provide a much needed intervention."

The researchers explored the potential beneficial impact of intra-hippocampal transplantation of fetal-derived human neural stem cells by transplanting the cells into laboratory rats a month after the animals were subjected to cranial irradiation with resulting cognitive deficits. The stem cells were FDA-approved human, fetal-derived neural stem cells provided by Neuralstem, Inc.

"Engrafted stem cells underwent extensive neuronal differentiation, formed new synaptic contacts, released neurotrophic factors, and showed an advanced degree of structural integration into the motor circuitry," reported the research team.

They found that the test animals showed improved hippocampal spatial memory and hippocampal-related "fear conditioning performance" when compared to a control group of irradiated animals that did not receive stem cell transplantation. The engrafted cells also migrated and differentiated into neural and glial subtypes in areas of the hippocampus.

"The engrafted stem cells survived and differentiated throughout an area of the hippocampus and significantly ameliorated cognitive dysfunction as shown at a one-month follow-up on the irradiated animals," said Dr. Limoli. "While it is premature to presume efficacy in the absence of human data, our efforts to thwart cognitive dysfunction by cell replacement therapy with fetal stem cell transplantation may provide an experimental backdrop for a potential treatment for cranially irradiated patients who developed cognitive dysfunctions."

"Cognitive dysfunction is an unfortunate side effect of the therapeutic use of radiation therapy for brain cancer and the identification of ways to ameliorate the dysfunction, such as the application of stem cell transplantation, is a significant area of research" said Dr. Paul R. Sanberg, distinguished professor at the Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL.

"This study is an important step towards the development of a clinical therapy, though further research is still required."


'/>"/>

Contact: Bob Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Fetal exposure to PVC plastic chemical linked to obesity in offspring
3. Pandemic vaccination did not increase risk of fetal death
4. Signaling pathway linked to fetal alcohol risk
5. New genetic link found between normal fetal growth and cancer
6. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
7. CWRU dental researchers NIDCR grant targets oral bacteria and fetal death link
8. New protocol developed to decontaminate human fetal tissues used for cell transplantation
9. Fetal programming of sweet tastes elicited pleasure
10. Fetal stress disrupts the way genes are transmitted
11. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
(Date:1/28/2016)... JOSE, Calif., Jan. 28, 2016 Synaptics (NASDAQ: SYNA ... results for its second quarter ended December 31, 2015. ... second quarter of fiscal 2016 increased 2 percent compared to the ... second quarter of fiscal 2016 was $35.0 million, or $0.93 per ... Non-GAAP net income for the first quarter of fiscal 2016 grew ...
(Date:1/25/2016)... Software, the world-leading supplier of image data management solutions ... data management solution OMERO Plus for the newly established ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... analysis measures the characteristics and behavior of cells, tissues ... as health and disease, the presence or absence of ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... , ... February 03, 2016 , ... ... Linux and Unix visualization solutions today announced the addition of a powerful “Session ... users to see the current state of the remote Linux desktop or other ...
(Date:2/3/2016)... Calif. , Feb. 3, 2016  Today, Symphony ... of AlphaImpactRx , a leading provider of primary ... companies to IMS Health , a global information ... complementary offerings, capabilities and technologies will be integrated into ... growing global primary market research capabilities. ...
(Date:2/3/2016)... NEW YORK. (PRWEB) , ... February 03, 2016 ... ... manufacturer of silicon (Si) and InGaAs chips and wafers, and InP epi wafers ... ranging from silicon detectors–including photodiodes, photo transistors, and Avalanche photodiodes–to Si and ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... clusters of commensal, symbiotic and pathogenic microorganisms that ... human body. The human microbiome is involved in ... healthy life. Majority of the microorganisms benefit humans ... otherwise not possess. These include metabolism of complex ...
Breaking Biology Technology: