Navigation Links
Fetal exposure to nicotine increases long-term risk of obesity
Date:1/16/2014

Many women are encouraged to quit smoking when they become pregnant using nicotine replacement therapy (NRT) whether as gum, transdermal patches, nasal spray or lozenges. But new research from Western University in London, Canada, has shown that nicotine from either smoking or NRT causes a wide range of long-term adverse reactions for the offspring, including an increased risk of obesity and metabolic syndrome by influencing the liver to produce more triglyceride. The research, led by Daniel Hardy, PhD, of the Schulich School of Medicine & Dentistry is published online in the journal "Toxicology and Applied Pharmacology."

"We knew smoking was bad during pregnancy. But the problem is one fifth of pregnant women in Canada continue to smoke, and 30 prospective studies have shown us that that babies born to smoking mothers have a 47 per cent increase in the odds of becoming overweight. And here's the interesting thing, that's even after adjusting for mom's diet and socioeconomic status," says Hardy, an assistant professor in the Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology "Our studies were designed to find if there is a biological basis between nicotine exposure from either NRT or smoking, and obesity and metabolic syndrome later in the offspring's life."

Working in collaboration with Alison Holloway, PhD, of McMaster University, Hardy gave pregnant laboratory rats the same amount of nicotine, adjusted for weight, that an average smoker receives (1 mg per kg a day). The offspring were born smaller in size, but six months later when they reached adulthood, the rats had developed an increase in liver and circulating triglycerides, a hallmark of obesity. The study also demonstrated that the nicotine-exposed liver, long-term, is making more triglycerides via transcriptional and epigenetic changes.

Hardy is also interested in finding out if increased perinatal doses of folic acid would prevent or reverse the nicotine damage to the developing liver. Folic acid has been shown to reduce circulating triglycerides in animal studies, and smoking moms have been found to have low levels of folate so he says, it is conceivable. He is also studying the long-term effects of nicotine on nursing babies.

Hardy agrees that, compared to smoking, NRT is the lesser of two evils, but he says clinicians may need to look more closely at the long-term safety and efficacy of nicotine in pregnancy on postnatal health and well-being.


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Fetal exposure to PVC plastic chemical linked to obesity in offspring
3. Pandemic vaccination did not increase risk of fetal death
4. Signaling pathway linked to fetal alcohol risk
5. New genetic link found between normal fetal growth and cancer
6. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
7. CWRU dental researchers NIDCR grant targets oral bacteria and fetal death link
8. New protocol developed to decontaminate human fetal tissues used for cell transplantation
9. Fetal programming of sweet tastes elicited pleasure
10. Fetal stress disrupts the way genes are transmitted
11. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/18/2016)... 2016 --> --> ... Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & ... the border security market and the continuing migration crisis in ... Europe has led visiongain to publish this unique ... --> defence & security companies in the border ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, ... launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, which ... to add Target to its list of well-respected retailers. This list includes such ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology: