Navigation Links
Fetal exposure to nicotine increases long-term risk of obesity
Date:1/16/2014

Many women are encouraged to quit smoking when they become pregnant using nicotine replacement therapy (NRT) whether as gum, transdermal patches, nasal spray or lozenges. But new research from Western University in London, Canada, has shown that nicotine from either smoking or NRT causes a wide range of long-term adverse reactions for the offspring, including an increased risk of obesity and metabolic syndrome by influencing the liver to produce more triglyceride. The research, led by Daniel Hardy, PhD, of the Schulich School of Medicine & Dentistry is published online in the journal "Toxicology and Applied Pharmacology."

"We knew smoking was bad during pregnancy. But the problem is one fifth of pregnant women in Canada continue to smoke, and 30 prospective studies have shown us that that babies born to smoking mothers have a 47 per cent increase in the odds of becoming overweight. And here's the interesting thing, that's even after adjusting for mom's diet and socioeconomic status," says Hardy, an assistant professor in the Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology "Our studies were designed to find if there is a biological basis between nicotine exposure from either NRT or smoking, and obesity and metabolic syndrome later in the offspring's life."

Working in collaboration with Alison Holloway, PhD, of McMaster University, Hardy gave pregnant laboratory rats the same amount of nicotine, adjusted for weight, that an average smoker receives (1 mg per kg a day). The offspring were born smaller in size, but six months later when they reached adulthood, the rats had developed an increase in liver and circulating triglycerides, a hallmark of obesity. The study also demonstrated that the nicotine-exposed liver, long-term, is making more triglycerides via transcriptional and epigenetic changes.

Hardy is also interested in finding out if increased perinatal doses of folic acid would prevent or
'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study finds Western diet detrimental to fetal hippocampal tissue transplants
2. Fetal exposure to PVC plastic chemical linked to obesity in offspring
3. Pandemic vaccination did not increase risk of fetal death
4. Signaling pathway linked to fetal alcohol risk
5. New genetic link found between normal fetal growth and cancer
6. Fetal neuromaturation associated with mothers exposure to ddt and other environmental contaminants
7. CWRU dental researchers NIDCR grant targets oral bacteria and fetal death link
8. New protocol developed to decontaminate human fetal tissues used for cell transplantation
9. Fetal programming of sweet tastes elicited pleasure
10. Fetal stress disrupts the way genes are transmitted
11. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... popular culture, mathematics is often deemed inaccessible or esoteric. ... more important role in our daily lives and a ... ideas often behind the scenes. , UC Santa ... Mathematics and an assistant professor of mechanical engineering, often ... of his recent research published in the Proceedings ...
(Date:9/29/2014)... that a combination of a real-time feedback system together ... residence resulted in a reduction of 37% in energy ... 1360.49 kWh, which is equivalent to a reduction of ... , In contrast, another eight halls, exposed only ... resulted in saw a 3.5% reduction in energy consumption. ...
(Date:9/29/2014)... not normally considered capable of doing anything on their ... move through water. In the future, such moving droplets ... your own to be self-moving is a ... entities can be self-moving, report researchers from University of ... Czech Republic. , The researchers have made alcohol droplets ...
Breaking Biology News(10 mins):At the interface of math and science 2At the interface of math and science 3At the interface of math and science 4Scientists make droplets move on their own 2
... Mellon University President Subra Suresh has been elected a ... the only current university president to be elected to ... is among the highest professional distinctions accorded to engineers, ... those who have made outstanding contributions to their fields. ...
... Medicine of the National Academies honored members Donald Berwick, R. ... today at the IOM,s 43rd annual meeting. ... member for distinguished service over an extended period. He ... Care in America, which produced the landmark reports To Err ...
... The Yangtze finless porpoise, which inhabits the high-traffic waters ... endangered, with only about 1,000 animals alive today. Scientists ... colleagues are using medical technology to shed new light ... waterway punctuated by constant shipping, dredging, and underwater construction. ...
Cached Biology News:Carnegie Mellon President Subra Suresh elected to Institute of Medicine 2Institute of Medicine honors members for outstanding service 2Institute of Medicine honors members for outstanding service 3Seeing in the dark 2Seeing in the dark 3
(Date:9/30/2014)... September 30, 2014 UFP Technologies, ... specialty packaging has recently introduced a custom insulated ... Pack . The new insulated shipper solves the ... distribution process. UFP Technologies’ BioShell is a universal ... during storage, handling and shipping. The insulated shipper ...
(Date:9/30/2014)... Ontario, Canada (PRWEB) September 30, 2014 Back ... based on 500 square feet. per employee, which included space ... world back then.” says Jeff Howell, partner at Nidea ... advisory firm in Toronto. “By the year 2000, however, ... are now seeing that number come down to 175 to ...
(Date:9/29/2014)... Each year in the US, ... attention. In the military, burn injury is a ... medical care. More than 800 service members sustained ... heal slowly, remain inflamed and often become infected, ... and functionally damaging. While developments in supportive care ...
(Date:9/29/2014)... of the military conflicts in Iraq and Afghanistan, more ... with traumatic brain injury caused by exposure to bomb ... devices, or IEDs. Symptoms of traumatic brain injury can ... nausea, to more severe impairments in memory and cognition. ... has recognized the critical importance and complexity of this ...
Breaking Biology Technology:UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Faster Healing with Fewer Scars 2Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... , QIAshredder spin columns are designed for simple and rapid homogenization , of cell and ... , , Format: , ... , , Sample source: ... plant cell or tissue lysates, white blood cell lysates, , ...
... , , , , This ... human cancer-related genes for functional genomics research using , RNAi. ... , , , , ... cancer researchers (see table below for a list of genes). Every siRNA has , ...
... Competent Cells for added , convenience, , , , , , , ... Included , Concentration , , , ... , , , ... 50 ng/l, , , Ligation Master ...
Cached Biology Technology:QIAshredder Homogenizer 2Cancer siRNA Oligo Set Version 1.0 2Cancer siRNA Oligo Set Version 1.0 3Cancer siRNA Oligo Set Version 1.0 4
EGTA, 50 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
RABBIT ANTI NEOPTERIN...
... Dog serum is collected from fasted mixed breed, ... Available Anticoagulants: N-02: Citrate ... K2EDTA N-08: Potassium Oxalate N-10: ... N-05: ACD N-07: CPD ...
Biology Products: